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TPM1 tropomyosin 1 [ Homo sapiens (human) ]

Gene ID: 7168, updated on 9-Dec-2018

Summary

Official Symbol
TPM1provided by HGNC
Official Full Name
tropomyosin 1provided by HGNC
Primary source
HGNC:HGNC:12010
See related
Ensembl:ENSG00000140416 MIM:191010
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CMH3; TMSA; CMD1Y; LVNC9; C15orf13; HEL-S-265; HTM-alpha
Summary
This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]
Expression
Biased expression in heart (RPKM 615.8), prostate (RPKM 140.5) and 9 other tissues See more
Orthologs

Genomic context

See TPM1 in Genome Data Viewer
Location:
15q22.2
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 15 NC_000015.10 (63042639..63071915)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (63334838..63364114)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene talin 2 Neighboring gene uncharacterized LOC105370854 Neighboring gene nuclease-sensitive element-binding protein 1 pseudogene Neighboring gene VISTA enhancer hs2160 Neighboring gene TPM1 antisense RNA Neighboring gene uncharacterized LOC107984798

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

Professional guidelines

Description
Professional guideline
ACMG 2013

The ACMG recommends that laboratories performing clinical sequencing seek and report mutations in TPM1 that are pathogenic or expected to be pathogenic.

GuidelinePubMed

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated (2015-11-09)

ClinGen Genome Curation Page
Triplosensitivity

No evidence available (Last evaluated (2015-11-09)

ClinGen Genome Curation Page

NHGRI GWAS Catalog

Description
A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium.
NHGRI GWA Catalog
Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci.
NHGRI GWA Catalog
New gene functions in megakaryopoiesis and platelet formation.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol Exposure of human skin fibroblasts to HIV-1 protease induces the degradation of the vimentin filament network and the disappearance of the tropomyosin isoforms microfilament network PubMed
gag-pol HIV-1 protease cleaves tropomyosin in vitro at positions 30, 51, and 87 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Adrenergic signaling in cardiomyocytes, organism-specific biosystem (from KEGG)
    Adrenergic signaling in cardiomyocytes, organism-specific biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
  • Adrenergic signaling in cardiomyocytes, conserved biosystem (from KEGG)
    Adrenergic signaling in cardiomyocytes, conserved biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
  • Cardiac muscle contraction, organism-specific biosystem (from KEGG)
    Cardiac muscle contraction, organism-specific biosystemContraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation...
  • Cardiac muscle contraction, conserved biosystem (from KEGG)
    Cardiac muscle contraction, conserved biosystemContraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation...
  • Dilated cardiomyopathy, organism-specific biosystem (from KEGG)
    Dilated cardiomyopathy, organism-specific biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
  • Dilated cardiomyopathy, conserved biosystem (from KEGG)
    Dilated cardiomyopathy, conserved biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
  • Hypertrophic cardiomyopathy (HCM), organism-specific biosystem (from KEGG)
    Hypertrophic cardiomyopathy (HCM), organism-specific biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
  • Hypertrophic cardiomyopathy (HCM), conserved biosystem (from KEGG)
    Hypertrophic cardiomyopathy (HCM), conserved biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
  • MicroRNAs in cancer, organism-specific biosystem (from KEGG)
    MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • MicroRNAs in cancer, conserved biosystem (from KEGG)
    MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • Muscle contraction, organism-specific biosystem (from REACTOME)
    Muscle contraction, organism-specific biosystemIn this module, the processes by which calcium binding triggers actin - myosin interactions and force generation in smooth and striated muscle tissues are annotated.
  • Smooth Muscle Contraction, organism-specific biosystem (from REACTOME)
    Smooth Muscle Contraction, organism-specific biosystemLayers of smooth muscle cells can be found in the walls of numerous organs and tissues within the body. Smooth muscle tissue lacks the striated banding pattern characteristic of skeletal and cardiac ...
  • Striated Muscle Contraction, organism-specific biosystem (from REACTOME)
    Striated Muscle Contraction, organism-specific biosystemStriated muscle contraction is a process whereby force is generated within striated muscle tissue, resulting in a change in muscle geometry, or in short, increased force being exerted on the tendons....
  • Striated Muscle Contraction, organism-specific biosystem (from WikiPathways)
    Striated Muscle Contraction, organism-specific biosystemMuscle contraction is the process where muscle tissue is activated by a signal from the nervous system. In case of voluntary action the nervous signals are initiated from the brain by so called actio...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin binding TAS
Traceable Author Statement
more info
PubMed 
actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin filament binding ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoskeletal protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
identical protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
structural constituent of cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
structural constituent of muscle TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cardiac muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cardiac muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to reactive oxygen species IEP
Inferred from Expression Pattern
more info
PubMed 
cytoskeleton organization TAS
Traceable Author Statement
more info
PubMed 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
muscle contraction TAS
Traceable Author Statement
more info
 
muscle filament sliding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
muscle filament sliding TAS
Traceable Author Statement
more info
 
negative regulation of cell migration ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of vascular associated smooth muscle cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of vascular smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of ATPase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of heart rate by epinephrine ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of stress fiber assembly ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
regulation of cell shape IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of heart contraction TAS
Traceable Author Statement
more info
PubMed 
regulation of muscle contraction TAS
Traceable Author Statement
more info
PubMed 
ruffle organization ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
sarcomere organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
ventricular cardiac muscle tissue morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
wound healing ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
actin cytoskeleton IDA
Inferred from Direct Assay
more info
 
actin filament IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
bleb IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
muscle thin filament tropomyosin TAS
Traceable Author Statement
more info
PubMed 
ruffle membrane IDA
Inferred from Direct Assay
more info
PubMed 
sarcomere TAS
Traceable Author Statement
more info
PubMed 
stress fiber IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
tropomyosin alpha-1 chain
Names
cardiomyopathy, hypertrophic 3
epididymis secretory protein Li 265
sarcomeric tropomyosin kappa

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007557.1 RefSeqGene

    Range
    5001..28455
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000366.5NP_000357.3  tropomyosin alpha-1 chain isoform Tpm1.5cy

    See identical proteins and their annotated locations for NP_000357.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (Tpm1.5, also known as variant 5) contains an alternate, in-frame exon and uses an alternate in-frame splice site and upstream stop codon, compared to variant Tpm1.1. It encodes isoform Tpm1.5cy, which has a different C-terminus, compared to isoform Tpm1.1st.
    Source sequence(s)
    BC007433, BG107949, CN423344
    Consensus CDS
    CCDS10181.1
    UniProtKB/Swiss-Prot
    P09493
    UniProtKB/TrEMBL
    A0A0K0K1I0
    Related
    ENSP00000288398.6, ENST00000288398.10
    Conserved Domains (1) summary
    pfam00261
    Location:48282
    Tropomyosin; Tropomyosin
  2. NM_001018004.1NP_001018004.1  tropomyosin alpha-1 chain isoform Tpm1.6cy

    See identical proteins and their annotated locations for NP_001018004.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (Tpm1.6, also known as variant 3) contains an alternate, in-frame exon in the 3' coding region, compared to variant Tpm1.1. It encodes isoform Tpm1.6cy, also known as the TM-2 fibroblast isoform, which has a distinct C-terminus, compared to isoform Tpm1.1st.
    Source sequence(s)
    AC079328, AJ000147, BG107949
    Consensus CDS
    CCDS58369.1
    UniProtKB/Swiss-Prot
    P09493
    UniProtKB/TrEMBL
    O15513
    Related
    ENSP00000453941.1, ENST00000559556.5
    Conserved Domains (1) summary
    pfam00261
    Location:48282
    Tropomyosin; Tropomyosin
  3. NM_001018005.1NP_001018005.1  tropomyosin alpha-1 chain isoform Tpm1.1st

    See identical proteins and their annotated locations for NP_001018005.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (Tpm1.1, also known as variant 1) represents the shortest transcript. It encodes the longest isoform (Tpm1.1st), also known as the fast skeletal muscle isoform.
    Source sequence(s)
    BC007433, BG107949, M19713
    Consensus CDS
    CCDS45273.1
    UniProtKB/Swiss-Prot
    P09493
    UniProtKB/TrEMBL
    D9YZV4
    Related
    ENSP00000385107.3, ENST00000403994.7
    Conserved Domains (1) summary
    pfam00261
    Location:48282
    Tropomyosin; Tropomyosin
  4. NM_001018006.1NP_001018006.1  tropomyosin alpha-1 chain isoform Tpm1.7cy

    See identical proteins and their annotated locations for NP_001018006.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (Tpm1.7, also known as variant 4) contains alternate, in-frame exons in the 3' coding region, compared to variant Tpm1.1. It encodes isoform Tpm1.7cy, also known as the TM-3 fibroblast isoform, which has a distinct C-terminus, compared to isoform Tpm1.1st.
    Source sequence(s)
    AC079328, AJ000147, BG107949
    Consensus CDS
    CCDS32263.1
    UniProtKB/Swiss-Prot
    P09493
    UniProtKB/TrEMBL
    D9YZV5, O15513
    Related
    ENSP00000351022.3, ENST00000358278.7
    Conserved Domains (1) summary
    pfam00261
    Location:48282
    Tropomyosin; Tropomyosin
  5. NM_001018007.1NP_001018007.1  tropomyosin alpha-1 chain isoform Tpm1.4sm

    See identical proteins and their annotated locations for NP_001018007.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (Tpm1.4, also known as variant 2) contains alternate, in-frame exons in the 5' and 3' coding region, compared to variant Tpm1.1. It encodes isoform Tpm1.4sm, also known as the smooth muscle isoform, which has distinct N- and C-termini, compared to isoform Tpm1.1st.
    Source sequence(s)
    AL050179, BG107949
    Consensus CDS
    CCDS32262.1
    UniProtKB/Swiss-Prot
    P09493
    UniProtKB/TrEMBL
    A0A024R5W6
    Related
    ENSP00000267996.7, ENST00000267996.11
    Conserved Domains (1) summary
    pfam00261
    Location:48282
    Tropomyosin; Tropomyosin
  6. NM_001018008.1NP_001018008.1  tropomyosin alpha-1 chain isoform Tpm1.12br

    See identical proteins and their annotated locations for NP_001018008.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (Tpm1.12, also known as variant 6) contains alternate in-frame exons in the 5' and 3' coding region, compared to variant Tpm1.1. It encodes isoform Tpm1.12br, also known as the TMBr-3 brain isoform, which has distinct N- and C-termini and is shorter than isoform Tpm1.1st.
    Source sequence(s)
    AC079328, BC050473, BC053545
    Consensus CDS
    CCDS32264.1
    UniProtKB/Swiss-Prot
    P09493
    UniProtKB/TrEMBL
    D9YZV7
    Related
    ENSP00000334624.4, ENST00000334895.10
    Conserved Domains (1) summary
    pfam00261
    Location:12244
    Tropomyosin; Tropomyosin
  7. NM_001018020.1NP_001018020.1  tropomyosin alpha-1 chain isoform Tpm1.3sm

    See identical proteins and their annotated locations for NP_001018020.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (Tpm1.3, also known as variant 7) contains alternate, in-frame exons in the coding region, compared to variant Tpm1.1. It encodes isoform Tpm1.3sm, which has distinct N- and C-termini, compared to isoform Tpm1.1st.
    Source sequence(s)
    AC079328, AJ000147, BG107949, BX458841
    Consensus CDS
    CCDS58368.1
    UniProtKB/Swiss-Prot
    P09493
    UniProtKB/TrEMBL
    O15513
    Related
    ENSP00000452879.1, ENST00000559397.6
    Conserved Domains (1) summary
    pfam00261
    Location:48282
    Tropomyosin; Tropomyosin
  8. NM_001301244.1NP_001288173.1  tropomyosin alpha-1 chain isoform Tpm1.2st

    See identical proteins and their annotated locations for NP_001288173.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (Tpm1.2, also known as variant 8) contains an alternate, in-frame exon in the 5' coding region, compared to variant Tpm1.1. It encodes isoform Tpm1.2st, which has a distinct N-terminus, compared to isoform Tpm1.1st.
    Source sequence(s)
    AY640414, CD679271, CN423297
    Consensus CDS
    CCDS86459.1
    UniProtKB/Swiss-Prot
    P09493
    Related
    ENSP00000453955.2, ENST00000561266.6
    Conserved Domains (2) summary
    pfam00261
    Location:48282
    Tropomyosin; Tropomyosin
    pfam07851
    Location:180274
    TMPIT; TMPIT-like protein
  9. NM_001301289.1NP_001288218.1  tropomyosin alpha-1 chain isoform Tpm1.8cy

    See identical proteins and their annotated locations for NP_001288218.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (Tpm1.8, also known as variant 9) contains alternate in-frame exons in the 5' and 3' coding region, compared to variant Tpm1.1. It encodes isoform Tpm1.8cy, which has distinct N- and C-termini and is shorter than isoform Tpm1.1st. Variants Tpm1.8, Tpm1.9 and Tpm1.13 encode isoforms that are the same length, but have distinct protein sequences.
    Source sequence(s)
    AC079328
    UniProtKB/TrEMBL
    B7Z722
    Conserved Domains (2) summary
    pfam00261
    Location:12246
    Tropomyosin; Tropomyosin
    pfam07851
    Location:144228
    TMPIT; TMPIT-like protein
  10. NM_001330344.1NP_001317273.1  tropomyosin alpha-1 chain isoform Tpm1.9cy

    Status: REVIEWED

    Description
    Transcript Variant: This variant (Tpm1.9, also known as variant 10) contains alternate, in-frame exons in the 5' and 3' coding region, compared to variant Tpm1.1. It encodes isoform Tpm1.9cy, which has distinct N- and C-termini, compared to isoform Tpm1.1st. Variants Tpm1.8, Tpm1.9 and Tpm1.13 encode isoforms that are the same length, but have distinct protein sequences.
    Source sequence(s)
    AC079328, AL050179, AL558518
    Consensus CDS
    CCDS81892.1
    UniProtKB/Swiss-Prot
    P09493
    UniProtKB/TrEMBL
    H7BYY1
    Related
    ENSP00000384315.4, ENST00000404484.9
    Conserved Domains (1) summary
    pfam00261
    Location:12246
    Tropomyosin; Tropomyosin
  11. NM_001330346.1NP_001317275.1  tropomyosin alpha-1 chain isoform Tpm1.13

    Status: REVIEWED

    Description
    Transcript Variant: This variant (Tpm1.13, also known as variant 11) has a different 5' structure compared to variant Tpm1.1. It encodes isoform Tpm1.13, which has a distinct N-terminus, compared to isoform Tpm1.1st. Variants Tpm1.8, Tpm1.9 and Tpm1.13 encode isoforms that are the same length, but have distinct protein sequences.
    Source sequence(s)
    AC079328, BC007433
    Consensus CDS
    CCDS81894.1
    UniProtKB/Swiss-Prot
    P09493
    UniProtKB/TrEMBL
    H0YK48
    Related
    ENSP00000452658.1, ENST00000559281.6
    Conserved Domains (1) summary
    pfam00261
    Location:12246
    Tropomyosin; Tropomyosin
  12. NM_001330351.1NP_001317280.1  tropomyosin alpha-1 chain isoform 12

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) contains alternate, in-frame exons in the 5' and 3' coding region, compared to variant Tpm1.1. It encodes isoform 12, which has distinct N- and C-termini, compared to isoform Tpm1.1st.
    Source sequence(s)
    AC079328, AL050179
    Consensus CDS
    CCDS81891.1
    UniProtKB/Swiss-Prot
    P09493
    UniProtKB/TrEMBL
    F5H7S3
    Related
    ENSP00000322577.7, ENST00000317516.12
    Conserved Domains (1) summary
    pfam00261
    Location:12244
    Tropomyosin; Tropomyosin
  13. NM_001365776.1NP_001352705.1  tropomyosin alpha-1 chain isoform Tpm1.10br

    Status: REVIEWED

    Source sequence(s)
    AC079328
    Conserved Domains (1) summary
    pfam00261
    Location:48280
    Tropomyosin; Tropomyosin
  14. NM_001365777.1NP_001352706.1  tropomyosin alpha-1 chain isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC079328
    Conserved Domains (2) summary
    pfam00261
    Location:48259
    Tropomyosin; Tropomyosin
    pfam16526
    Location:1372
    CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels
  15. NM_001365778.1NP_001352707.1  tropomyosin alpha-1 chain isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC079328, AK131384
    Conserved Domains (2) summary
    pfam00261
    Location:90324
    Tropomyosin; Tropomyosin
    cl25633
    Location:1159
    HlyD; HlyD membrane-fusion protein of T1SS
  16. NM_001365779.1NP_001352708.1  tropomyosin alpha-1 chain isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC079328, M19714
    Conserved Domains (1) summary
    pfam00261
    Location:48282
    Tropomyosin; Tropomyosin
  17. NM_001365780.1NP_001352709.1  tropomyosin alpha-1 chain isoform Tpm1.11br

    Status: REVIEWED

    Source sequence(s)
    AC079328
    Conserved Domains (1) summary
    pfam00261
    Location:12223
    Tropomyosin; Tropomyosin
  18. NM_001365781.1NP_001352710.1  tropomyosin alpha-1 chain isoform 18

    Status: REVIEWED

    Source sequence(s)
    AC079328
    Conserved Domains (1) summary
    pfam00261
    Location:12246
    Tropomyosin; Tropomyosin
  19. NM_001365782.1NP_001352711.1  tropomyosin alpha-1 chain isoform 19

    Status: REVIEWED

    Source sequence(s)
    AC079328
    Conserved Domains (1) summary
    pfam00261
    Location:12246
    Tropomyosin; Tropomyosin

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p12 Primary Assembly

    Range
    63042639..63071915
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017022539.2XP_016878028.2  tropomyosin alpha-1 chain isoform X10

    Conserved Domains (1) summary
    pfam00261
    Location:48280
    Tropomyosin; Tropomyosin
  2. XM_005254645.3XP_005254702.3  tropomyosin alpha-1 chain isoform X9

    Conserved Domains (1) summary
    pfam00261
    Location:48280
    Tropomyosin; Tropomyosin
  3. XM_006720667.4XP_006720730.3  tropomyosin alpha-1 chain isoform X7

    Conserved Domains (1) summary
    pfam00261
    Location:48282
    Tropomyosin; Tropomyosin
  4. XM_005254639.4XP_005254696.3  tropomyosin alpha-1 chain isoform X6

    Conserved Domains (2) summary
    pfam00261
    Location:48259
    Tropomyosin; Tropomyosin
    pfam16526
    Location:1372
    CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels
  5. XM_005254638.4XP_005254695.3  tropomyosin alpha-1 chain isoform X5

    Conserved Domains (2) summary
    pfam00261
    Location:48259
    Tropomyosin; Tropomyosin
    pfam16526
    Location:1372
    CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels
  6. XM_017022538.2XP_016878027.2  tropomyosin alpha-1 chain isoform X8

    Conserved Domains (1) summary
    pfam00261
    Location:48282
    Tropomyosin; Tropomyosin
  7. XM_017022536.2XP_016878025.2  tropomyosin alpha-1 chain isoform X3

    Conserved Domains (2) summary
    pfam00261
    Location:48262
    Tropomyosin
    pfam16526
    Location:1372
    CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels
  8. XM_017022534.2XP_016878023.2  tropomyosin alpha-1 chain isoform X1

    Conserved Domains (2) summary
    pfam00261
    Location:48262
    Tropomyosin
    pfam16526
    Location:1372
    CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels
  9. XM_017022537.2XP_016878026.1  tropomyosin alpha-1 chain isoform X4

  10. XM_017022535.2XP_016878024.1  tropomyosin alpha-1 chain isoform X2

  11. XM_005254637.2XP_005254694.1  tropomyosin alpha-1 chain isoform X17

    UniProtKB/TrEMBL
    Q6ZN40
    Related
    ENSP00000350667.4, ENST00000357980.8
    Conserved Domains (2) summary
    pfam00261
    Location:90324
    Tropomyosin; Tropomyosin
    cl25633
    Location:1159
    HlyD; HlyD membrane-fusion protein of T1SS
  12. XM_024450040.1XP_024305808.1  tropomyosin alpha-1 chain isoform X16

    Conserved Domains (1) summary
    pfam00261
    Location:1136
    Tropomyosin
  13. XM_005254650.3XP_005254707.1  tropomyosin alpha-1 chain isoform X14

    See identical proteins and their annotated locations for XP_005254707.1

    Conserved Domains (1) summary
    pfam00261
    Location:12246
    Tropomyosin; Tropomyosin
  14. XM_005254647.3XP_005254704.1  tropomyosin alpha-1 chain isoform X13

    Conserved Domains (1) summary
    pfam00261
    Location:12223
    Tropomyosin; Tropomyosin
  15. XM_005254651.1XP_005254708.1  tropomyosin alpha-1 chain isoform X15

    Conserved Domains (1) summary
    pfam00261
    Location:12246
    Tropomyosin; Tropomyosin
  16. XM_005254646.2XP_005254703.1  tropomyosin alpha-1 chain isoform X12

    See identical proteins and their annotated locations for XP_005254703.1

    UniProtKB/TrEMBL
    B7Z596
    Related
    ENSP00000453724.1, ENST00000560959.5
    Conserved Domains (2) summary
    pfam00261
    Location:12226
    Tropomyosin; Tropomyosin
    cl19842
    Location:18122
    DUF2213; Uncharacterized protein conserved in bacteria (DUF2213)
  17. XM_017022540.1XP_016878029.1  tropomyosin alpha-1 chain isoform X11

RNA

  1. XR_002957675.1 RNA Sequence

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