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TPM1 tropomyosin 1 [ Homo sapiens (human) ]

Gene ID: 7168, updated on 4-Dec-2022

Summary

Official Symbol
TPM1provided by HGNC
Official Full Name
tropomyosin 1provided by HGNC
Primary source
HGNC:HGNC:12010
See related
Ensembl:ENSG00000140416 MIM:191010; AllianceGenome:HGNC:12010
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CMH3; TMSA; CMD1Y; LVNC9; C15orf13; HEL-S-265; HTM-alpha
Summary
This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy and dilated cardiomyopathy 1Y. [provided by RefSeq, Jun 2022]
Expression
Biased expression in heart (RPKM 615.8), prostate (RPKM 140.5) and 9 other tissues See more
Orthologs
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Genomic context

See TPM1 in Genome Data Viewer
Location:
15q22.2
Exon count:
14
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (63042747..63071915)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (60846575..60875760)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (63334946..63364114)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene talin 2 Neighboring gene uncharacterized LOC105370854 Neighboring gene Y-box-binding protein 1-like Neighboring gene VISTA enhancer hs2160 Neighboring gene TPM1 antisense RNA Neighboring gene uncharacterized LOC107984798

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Professional guidelines

Description
Professional guideline
ACMG 2013

The ACMG recommends that laboratories performing clinical sequencing seek and report mutations in TPM1 that are pathogenic or expected to be pathogenic.

GuidelinePubMed

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated 2015-11-09)

ClinGen Genome Curation Page
Triplosensitivity

No evidence available (Last evaluated 2015-11-09)

ClinGen Genome Curation Page

EBI GWAS Catalog

Description
A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium.
EBI GWAS Catalog
Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci.
EBI GWAS Catalog
New gene functions in megakaryopoiesis and platelet formation.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol Exposure of human skin fibroblasts to HIV-1 protease induces the degradation of the vimentin filament network and the disappearance of the tropomyosin isoforms microfilament network PubMed
gag-pol HIV-1 protease cleaves tropomyosin in vitro at positions 30, 51, and 87 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin binding TAS
Traceable Author Statement
more info
PubMed 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables actin filament binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables cytoskeletal protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables structural constituent of cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
enables structural constituent of muscle TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cardiac muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cardiac muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to reactive oxygen species IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cytoskeleton organization TAS
Traceable Author Statement
more info
PubMed 
involved_in muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in muscle filament sliding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in negative regulation of cell migration ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in negative regulation of vascular associated smooth muscle cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of vascular associated smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of ATP-dependent activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in positive regulation of cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in positive regulation of heart rate by epinephrine ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in positive regulation of stress fiber assembly ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in regulation of cell shape IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of heart contraction TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of muscle contraction TAS
Traceable Author Statement
more info
PubMed 
involved_in ruffle organization ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in sarcomere organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ventricular cardiac muscle tissue morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in wound healing ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
 
is_active_in actin filament IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in bleb IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
part_of muscle thin filament tropomyosin TAS
Traceable Author Statement
more info
PubMed 
located_in ruffle membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in sarcomere TAS
Traceable Author Statement
more info
PubMed 
located_in stress fiber IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
tropomyosin alpha-1 chain
Names
cardiomyopathy, hypertrophic 3
epididymis secretory protein Li 265
sarcomeric tropomyosin kappa

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007557.1 RefSeqGene

    Range
    5109..28540
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_387

mRNA and Protein(s)

  1. NM_000366.6NP_000357.3  tropomyosin alpha-1 chain isoform Tpm1.5cy

    See identical proteins and their annotated locations for NP_000357.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (Tpm1.5, also known as variant 5) contains an alternate, in-frame exon and uses an alternate in-frame splice site and upstream stop codon, compared to variant Tpm1.1. It encodes isoform Tpm1.5cy, which has a different C-terminus, compared to isoform Tpm1.1st.
    Source sequence(s)
    AC079328, BC007433, BG107949, CN423344
    Consensus CDS
    CCDS10181.1
    UniProtKB/Swiss-Prot
    P09493
    UniProtKB/TrEMBL
    A0A0K0K1I0
    Related
    ENSP00000288398.6, ENST00000288398.10
    Conserved Domains (1) summary
    pfam00261
    Location:48282
    Tropomyosin
  2. NM_001018004.2NP_001018004.1  tropomyosin alpha-1 chain isoform Tpm1.6cy

    See identical proteins and their annotated locations for NP_001018004.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (Tpm1.6, also known as variant 3) contains an alternate, in-frame exon in the 3' coding region, compared to variant Tpm1.1. It encodes isoform Tpm1.6cy, also known as the TM-2 fibroblast isoform, which has a distinct C-terminus, compared to isoform Tpm1.1st.
    Source sequence(s)
    AC079328, AJ000147
    Consensus CDS
    CCDS58369.1
    UniProtKB/Swiss-Prot
    P09493
    UniProtKB/TrEMBL
    O15513
    Related
    ENSP00000453941.1, ENST00000559556.5
    Conserved Domains (1) summary
    pfam00261
    Location:48282
    Tropomyosin
  3. NM_001018005.2NP_001018005.1  tropomyosin alpha-1 chain isoform Tpm1.1st

    See identical proteins and their annotated locations for NP_001018005.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (Tpm1.1, also known as variant 1) represents the shortest transcript. It encodes the longest isoform (Tpm1.1st), also known as the fast skeletal muscle isoform.
    Source sequence(s)
    AC079328, BC007433, BG107949, M19713
    Consensus CDS
    CCDS45273.1
    UniProtKB/Swiss-Prot
    P09493, Q9Y427
    UniProtKB/TrEMBL
    D9YZV4
    Related
    ENSP00000385107.4, ENST00000403994.9
    Conserved Domains (1) summary
    pfam00261
    Location:48282
    Tropomyosin
  4. NM_001018006.2NP_001018006.1  tropomyosin alpha-1 chain isoform Tpm1.7cy

    See identical proteins and their annotated locations for NP_001018006.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (Tpm1.7, also known as variant 4) contains alternate, in-frame exons in the 3' coding region, compared to variant Tpm1.1. It encodes isoform Tpm1.7cy, also known as the TM-3 fibroblast isoform, which has a distinct C-terminus, compared to isoform Tpm1.1st.
    Source sequence(s)
    AC079328, AJ000147
    Consensus CDS
    CCDS32263.1
    UniProtKB/Swiss-Prot
    P09493
    UniProtKB/TrEMBL
    D9YZV5, O15513
    Related
    ENSP00000351022.3, ENST00000358278.7
    Conserved Domains (1) summary
    pfam00261
    Location:48282
    Tropomyosin
  5. NM_001018007.2NP_001018007.1  tropomyosin alpha-1 chain isoform Tpm1.4sm

    See identical proteins and their annotated locations for NP_001018007.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (Tpm1.4, also known as variant 2) contains alternate, in-frame exons in the 5' and 3' coding region, compared to variant Tpm1.1. It encodes isoform Tpm1.4sm, also known as the smooth muscle isoform, which has distinct N- and C-termini, compared to isoform Tpm1.1st.
    Source sequence(s)
    AL050179, BG107949
    Consensus CDS
    CCDS32262.1
    UniProtKB/Swiss-Prot
    P09493
    UniProtKB/TrEMBL
    A0A024R5W6
    Related
    ENSP00000267996.7, ENST00000267996.11
    Conserved Domains (1) summary
    pfam00261
    Location:48282
    Tropomyosin
  6. NM_001018008.2NP_001018008.1  tropomyosin alpha-1 chain isoform Tpm1.12br

    See identical proteins and their annotated locations for NP_001018008.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (Tpm1.12, also known as variant 6) contains alternate in-frame exons in the 5' and 3' coding region, compared to variant Tpm1.1. It encodes isoform Tpm1.12br, also known as the TMBr-3 brain isoform, which has distinct N- and C-termini and is shorter than isoform Tpm1.1st.
    Source sequence(s)
    AC079328, BC050473, BC053545
    Consensus CDS
    CCDS32264.1
    UniProtKB/Swiss-Prot
    P09493
    UniProtKB/TrEMBL
    D9YZV7
    Related
    ENSP00000334624.4, ENST00000334895.10
    Conserved Domains (1) summary
    pfam00261
    Location:12244
    Tropomyosin
  7. NM_001018020.2NP_001018020.1  tropomyosin alpha-1 chain isoform Tpm1.3sm

    See identical proteins and their annotated locations for NP_001018020.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (Tpm1.3, also known as variant 7) contains alternate, in-frame exons in the coding region, compared to variant Tpm1.1. It encodes isoform Tpm1.3sm, which has distinct N- and C-termini, compared to isoform Tpm1.1st.
    Source sequence(s)
    AC079328, AJ000147, BG107949, BX458841
    Consensus CDS
    CCDS58368.1
    UniProtKB/Swiss-Prot
    P09493
    UniProtKB/TrEMBL
    O15513
    Related
    ENSP00000452879.1, ENST00000559397.6
    Conserved Domains (1) summary
    pfam00261
    Location:48282
    Tropomyosin
  8. NM_001301244.2NP_001288173.1  tropomyosin alpha-1 chain isoform Tpm1.2st

    See identical proteins and their annotated locations for NP_001288173.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (Tpm1.2, also known as variant 8) contains an alternate, in-frame exon in the 5' coding region, compared to variant Tpm1.1. It encodes isoform Tpm1.2st, which has a distinct N-terminus, compared to isoform Tpm1.1st.
    Source sequence(s)
    AC079328, AY640414, CD679271, CN423297
    Consensus CDS
    CCDS86459.1
    UniProtKB/Swiss-Prot
    P09493
    Related
    ENSP00000453955.2, ENST00000561266.6
    Conserved Domains (1) summary
    pfam00261
    Location:48282
    Tropomyosin
  9. NM_001301289.2NP_001288218.1  tropomyosin alpha-1 chain isoform Tpm1.8cy

    See identical proteins and their annotated locations for NP_001288218.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (Tpm1.8, also known as variant 9) contains alternate in-frame exons in the 5' and 3' coding region, compared to variant Tpm1.1. It encodes isoform Tpm1.8cy, which has distinct N- and C-termini and is shorter than isoform Tpm1.1st. Variants Tpm1.8, Tpm1.9 and Tpm1.13 encode isoforms that are the same length, but have distinct protein sequences.
    Source sequence(s)
    AC079328
    UniProtKB/TrEMBL
    B7Z722
    Conserved Domains (1) summary
    pfam00261
    Location:12246
    Tropomyosin
  10. NM_001330344.2NP_001317273.1  tropomyosin alpha-1 chain isoform Tpm1.9cy

    Status: REVIEWED

    Description
    Transcript Variant: This variant (Tpm1.9, also known as variant 10) contains alternate, in-frame exons in the 5' and 3' coding region, compared to variant Tpm1.1. It encodes isoform Tpm1.9cy, which has distinct N- and C-termini, compared to isoform Tpm1.1st. Variants Tpm1.8, Tpm1.9 and Tpm1.13 encode isoforms that are the same length, but have distinct protein sequences.
    Source sequence(s)
    AC079328, AL050179, AL558518
    Consensus CDS
    CCDS81892.1
    UniProtKB/Swiss-Prot
    P09493
    UniProtKB/TrEMBL
    H7BYY1
    Related
    ENSP00000384315.4, ENST00000404484.9
    Conserved Domains (1) summary
    pfam00261
    Location:12246
    Tropomyosin
  11. NM_001330346.2NP_001317275.1  tropomyosin alpha-1 chain isoform Tpm1.13

    Status: REVIEWED

    Description
    Transcript Variant: This variant (Tpm1.13, also known as variant 11) has a different 5' structure compared to variant Tpm1.1. It encodes isoform Tpm1.13, which has a distinct N-terminus, compared to isoform Tpm1.1st. Variants Tpm1.8, Tpm1.9 and Tpm1.13 encode isoforms that are the same length, but have distinct protein sequences.
    Source sequence(s)
    AC079328, BC007433
    Consensus CDS
    CCDS81894.1
    UniProtKB/Swiss-Prot
    P09493
    UniProtKB/TrEMBL
    H0YK48
    Related
    ENSP00000452658.1, ENST00000559281.6
    Conserved Domains (1) summary
    pfam00261
    Location:12246
    Tropomyosin
  12. NM_001330351.2NP_001317280.1  tropomyosin alpha-1 chain isoform 12

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) contains alternate, in-frame exons in the 5' and 3' coding region, compared to variant Tpm1.1. It encodes isoform 12, which has distinct N- and C-termini, compared to isoform Tpm1.1st.
    Source sequence(s)
    AC079328, AL050179
    Consensus CDS
    CCDS81891.1
    UniProtKB/Swiss-Prot
    P09493
    UniProtKB/TrEMBL
    F5H7S3
    Related
    ENSP00000322577.7, ENST00000317516.12
    Conserved Domains (1) summary
    pfam00261
    Location:12244
    Tropomyosin
  13. NM_001365776.1NP_001352705.1  tropomyosin alpha-1 chain isoform Tpm1.10br

    Status: REVIEWED

    Source sequence(s)
    AC079328
    Related
    ENST00000651344.1
    Conserved Domains (1) summary
    pfam00261
    Location:48280
    Tropomyosin
  14. NM_001365777.1NP_001352706.1  tropomyosin alpha-1 chain isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC079328
    Conserved Domains (2) summary
    pfam00261
    Location:48259
    Tropomyosin
    pfam16526
    Location:1372
    CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels
  15. NM_001365778.1NP_001352707.1  tropomyosin alpha-1 chain isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC079328, AK131384
    Consensus CDS
    CCDS92009.1
    UniProtKB/TrEMBL
    Q6ZN40
    Related
    ENSP00000350667.4, ENST00000357980.9
    Conserved Domains (2) summary
    TIGR00998
    Location:1159
    8a0101; efflux pump membrane protein (multidrug resistance protein A)
    pfam00261
    Location:90324
    Tropomyosin
  16. NM_001365779.1NP_001352708.1  tropomyosin alpha-1 chain isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC079328, M19714
    Consensus CDS
    CCDS92010.1
    UniProtKB/TrEMBL
    H0YL52
    Related
    ENSP00000453062.2, ENST00000560970.6
    Conserved Domains (1) summary
    pfam00261
    Location:48282
    Tropomyosin; Tropomyosin
  17. NM_001365780.1NP_001352709.1  tropomyosin alpha-1 chain isoform Tpm1.11br

    Status: REVIEWED

    Source sequence(s)
    AC079328
    Consensus CDS
    CCDS92013.1
    UniProtKB/TrEMBL
    A0A494BZZ2
    Related
    ENSP00000498284.1, ENST00000651590.1
    Conserved Domains (1) summary
    pfam00261
    Location:12223
    Tropomyosin
  18. NM_001365781.2NP_001352710.1  tropomyosin alpha-1 chain isoform 18

    Status: REVIEWED

    Source sequence(s)
    AC079328
    Conserved Domains (1) summary
    pfam00261
    Location:12246
    Tropomyosin
  19. NM_001365782.1NP_001352711.1  tropomyosin alpha-1 chain isoform 19

    Status: REVIEWED

    Source sequence(s)
    AC079328
    Consensus CDS
    CCDS92012.1
    UniProtKB/TrEMBL
    H0YKJ4
    Related
    ENSP00000452830.2, ENST00000558910.3
    Conserved Domains (1) summary
    pfam00261
    Location:12246
    Tropomyosin; Tropomyosin
  20. NM_001407322.1NP_001394251.1  tropomyosin alpha-1 chain isoform 23

    Status: REVIEWED

    Source sequence(s)
    AC079328
  21. NM_001407323.1NP_001394252.1  tropomyosin alpha-1 chain isoform 24

    Status: REVIEWED

    Source sequence(s)
    AC079328
  22. NM_001407324.1NP_001394253.1  tropomyosin alpha-1 chain isoform 25

    Status: REVIEWED

    Source sequence(s)
    AC079328
  23. NM_001407325.1NP_001394254.1  tropomyosin alpha-1 chain isoform 26

    Status: REVIEWED

    Source sequence(s)
    AC079328
  24. NM_001407326.1NP_001394255.1  tropomyosin alpha-1 chain isoform 27

    Status: REVIEWED

    Source sequence(s)
    AC079328
  25. NM_001407327.1NP_001394256.1  tropomyosin alpha-1 chain isoform 28

    Status: REVIEWED

    Source sequence(s)
    AC079328
  26. NM_001407328.1NP_001394257.1  tropomyosin alpha-1 chain isoform 29

    Status: REVIEWED

    Source sequence(s)
    AC079328
  27. NM_001407329.1NP_001394258.1  tropomyosin alpha-1 chain isoform 30

    Status: REVIEWED

    Source sequence(s)
    AC079328
  28. NM_001407330.1NP_001394259.1  tropomyosin alpha-1 chain isoform Tpm1.5cy

    Status: REVIEWED

    Source sequence(s)
    AC079328
    Consensus CDS
    CCDS10181.1
    UniProtKB/TrEMBL
    A0A0K0K1I0
  29. NM_001407331.1NP_001394260.1  tropomyosin alpha-1 chain isoform 31

    Status: REVIEWED

    Source sequence(s)
    AC079328
  30. NM_001407332.1NP_001394261.1  tropomyosin alpha-1 chain isoform 32

    Status: REVIEWED

    Source sequence(s)
    AC079328
  31. NM_001407333.1NP_001394262.1  tropomyosin alpha-1 chain isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC079328
    UniProtKB/TrEMBL
    H0YL52
  32. NM_001407334.1NP_001394263.1  tropomyosin alpha-1 chain isoform 33

    Status: REVIEWED

    Source sequence(s)
    AC079328
  33. NM_001407335.1NP_001394264.1  tropomyosin alpha-1 chain isoform 33

    Status: REVIEWED

    Source sequence(s)
    AC079328
  34. NM_001407336.1NP_001394265.1  tropomyosin alpha-1 chain isoform 35

    Status: REVIEWED

    Source sequence(s)
    AC079328
  35. NM_001407337.1NP_001394266.1  tropomyosin alpha-1 chain isoform 36

    Status: REVIEWED

    Source sequence(s)
    AC079328
  36. NM_001407338.1NP_001394267.1  tropomyosin alpha-1 chain isoform 37

    Status: REVIEWED

    Source sequence(s)
    AC079328
  37. NM_001407340.1NP_001394269.1  tropomyosin alpha-1 chain isoform 38

    Status: REVIEWED

    Source sequence(s)
    AC079328
    Consensus CDS
    CCDS92011.1
    UniProtKB/TrEMBL
    B7Z596
  38. NM_001407341.1NP_001394270.1  tropomyosin alpha-1 chain isoform 39

    Status: REVIEWED

    Source sequence(s)
    AC079328
  39. NM_001407342.1NP_001394271.1  tropomyosin alpha-1 chain isoform 40

    Status: REVIEWED

    Source sequence(s)
    AC079328
  40. NM_001407344.1NP_001394273.1  tropomyosin alpha-1 chain isoform 41

    Status: REVIEWED

    Source sequence(s)
    AC079328

RNA

  1. NR_176337.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079328
  2. NR_176338.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079328
  3. NR_176339.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079328
  4. NR_176340.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079328
  5. NR_176341.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079328
  6. NR_176342.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079328
  7. NR_176343.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079328
  8. NR_176344.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079328
  9. NR_176345.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079328
  10. NR_176346.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079328
  11. NR_176347.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079328
  12. NR_176348.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079328
  13. NR_176349.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079328
  14. NR_176350.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079328
  15. NR_176351.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079328
  16. NR_176352.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079328
  17. NR_176353.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079328

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    63042747..63071915
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047433004.1XP_047288960.1  tropomyosin alpha-1 chain isoform X9

  2. XM_017022539.3XP_016878028.2  tropomyosin alpha-1 chain isoform X8

    Conserved Domains (1) summary
    pfam00261
    Location:48280
    Tropomyosin; Tropomyosin
  3. XM_047433003.1XP_047288959.1  tropomyosin alpha-1 chain isoform X7

  4. XM_047433001.1XP_047288957.1  tropomyosin alpha-1 chain isoform X3

  5. XM_047433000.1XP_047288956.1  tropomyosin alpha-1 chain isoform X1

  6. XM_006720667.5XP_006720730.3  tropomyosin alpha-1 chain isoform X5

    Conserved Domains (1) summary
    pfam00261
    Location:48282
    Tropomyosin
  7. XM_005254639.5XP_005254696.3  tropomyosin alpha-1 chain isoform X2

    Conserved Domains (2) summary
    pfam00261
    Location:48259
    Tropomyosin
    pfam16526
    Location:1372
    CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels
  8. XM_047433002.1XP_047288958.1  tropomyosin alpha-1 chain isoform X4

  9. XM_017022538.3XP_016878027.2  tropomyosin alpha-1 chain isoform X6

    Conserved Domains (1) summary
    pfam00261
    Location:48282
    Tropomyosin
  10. XM_005254650.4XP_005254707.1  tropomyosin alpha-1 chain isoform X12

    Conserved Domains (1) summary
    pfam00261
    Location:12246
    Tropomyosin
  11. XM_047433005.1XP_047288961.1  tropomyosin alpha-1 chain isoform X11

  12. XM_005254646.3XP_005254703.1  tropomyosin alpha-1 chain isoform X10

    UniProtKB/TrEMBL
    B7Z596
    Related
    ENSP00000453724.1, ENST00000560959.5
    Conserved Domains (2) summary
    pfam00261
    Location:12226
    Tropomyosin; Tropomyosin
    cl19842
    Location:18122
    DUF2213; Uncharacterized protein conserved in bacteria (DUF2213)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    60846575..60875760
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)