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SEC62 SEC62 homolog, preprotein translocation factor [ Homo sapiens (human) ]

Gene ID: 7095, updated on 22-Sep-2022

Summary

Official Symbol
SEC62provided by HGNC
Official Full Name
SEC62 homolog, preprotein translocation factorprovided by HGNC
Primary source
HGNC:HGNC:11846
See related
Ensembl:ENSG00000008952 MIM:602173; AllianceGenome:HGNC:11846
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HTP1; TP-1; Dtrp1; TLOC1
Summary
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC63 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 46.4), brain (RPKM 36.2) and 25 other tissues See more
Orthologs
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Genomic context

See SEC62 in Genome Data Viewer
Location:
3q26.2
Exon count:
9
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (169966807..169998373)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (172751093..172783070)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (169684595..169716161)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene sterile alpha motif domain containing 7 Neighboring gene FAM20B, glycosaminoglycan xylosylkinase pseudogene Neighboring gene four and a half LIM domains 1 pseudogene Neighboring gene uncharacterized LOC124909455 Neighboring gene G protein-coupled receptor 160 Neighboring gene RNA, U4 small nuclear 38, pseudogene Neighboring gene KMT5A pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 is identified to have a physical interaction with SEC62 homolog (SEC62) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ32803

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in rough endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
translocation protein SEC62
Names
SEC62 preprotein translocation factor
hTP-1
membrane protein SEC62, S.cerevisiae, homolog of
translocation protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003262.4NP_003253.1  translocation protein SEC62

    See identical proteins and their annotated locations for NP_003253.1

    Status: REVIEWED

    Source sequence(s)
    AC008040
    Consensus CDS
    CCDS3210.1
    UniProtKB/Swiss-Prot
    O00729, Q99442
    Related
    ENSP00000337688.4, ENST00000337002.9
    Conserved Domains (2) summary
    pfam05793
    Location:290369
    TFIIF_alpha; Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)
    pfam03839
    Location:170305
    Sec62; Translocation protein Sec62

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    169966807..169998373
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047448819.1XP_047304775.1  translocation protein SEC62 isoform X1

    UniProtKB/TrEMBL
    D3DNQ1
  2. XM_011513114.4XP_011511416.1  translocation protein SEC62 isoform X1

    See identical proteins and their annotated locations for XP_011511416.1

    UniProtKB/TrEMBL
    D3DNQ1
    Conserved Domains (2) summary
    pfam05793
    Location:252331
    TFIIF_alpha; Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)
    pfam03839
    Location:132267
    Sec62; Translocation protein Sec62

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    172751093..172783070
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)