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Sec62 SEC62 homolog (S. cerevisiae) [ Mus musculus (house mouse) ]

Gene ID: 69276, updated on 8-Jan-2023

Summary

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Official Symbol
Sec62provided by MGI
Official Full Name
SEC62 homolog (S. cerevisiae)provided by MGI
Primary source
MGI:MGI:1916526
See related
Ensembl:ENSMUSG00000027706 AllianceGenome:MGI:1916526
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HTP1; Dtrp1; Tloc1; 3100002M17Rik
Summary
Predicted to be involved in posttranslational protein targeting to membrane, translocation. Predicted to act upstream of or within posttranslational protein targeting to endoplasmic reticulum membrane. Predicted to be integral component of endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum and membrane. Orthologous to human SEC62 (SEC62 homolog, preprotein translocation factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 31.7), frontal lobe adult (RPKM 26.4) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Sec62 in Genome Data Viewer
Location:
3; 3 A3
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (30847025..30875412)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (30792876..30821263)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 31 Neighboring gene predicted gene 15462 Neighboring gene sterile alpha motif domain containing 7 Neighboring gene predicted gene, 33590 Neighboring gene predicted gene, 42198 Neighboring gene predicted gene, 42199 Neighboring gene G protein-coupled receptor 160

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Initial evidence for Sec62 as a prognostic marker in advanced head and neck squamous cell carcinoma. Wemmert S, et al. Oncol Lett, 2016 Mar. PMID 26998059, Free PMC Article
  2. Cotranslational stabilization of Sec62/63 within the ER Sec61 translocon is controlled by distinct substrate-driven translocation events. Conti BJ, et al. Mol Cell, 2015 Apr 16. PMID 25801167, Free PMC Article
  3. Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery. Fumagalli F, et al. Nat Cell Biol, 2016 Nov. PMID 27749824
  4. Mammalian SRP receptor switches the Sec61 translocase from Sec62 to SRP-dependent translocation. Jadhav B, et al. Nat Commun, 2015 Dec 4. PMID 26634806, Free PMC Article
  5. The Sec62-Sec63 translocon facilitates translocation of the C-terminus of membrane proteins. Jung SJ, et al. J Cell Sci, 2014 Oct 1. PMID 25097231

See all (32) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. identify Sec62 as a critical molecular component in maintenance and recovery of endoplasmic reticulum homeostasis
    Title: Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery.
  2. Interaction of ribosomes and Sec62 with the core Sec61 translocon is mutually exclusive.
    Title: Mammalian SRP receptor switches the Sec61 translocase from Sec62 to SRP-dependent translocation.
  3. The Sec62 protein plays a role in post-translational transport of presecretory proteins into endoplasmic reticulum.
    Title: Different effects of Sec61α, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within post-translational protein targeting to endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in post-translational protein targeting to membrane, translocation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in post-translational protein targeting to membrane, translocation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
translocation protein SEC62
Names
TP-1
translocation protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357528.1 → NP_001344457.1  translocation protein SEC62 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC158135
    Conserved Domains (2) summary
    pfam03839
    Location:170 → 304
    Sec62; Translocation protein Sec62
    cl27000
    Location:290 → 369
    TFIIFa; Transcription initiation factor IIF, alpha subunit, N-terminal region of RAP74. Subunit of transcription initiation complex involved in initiation, elongation and promoter escape.Tetramer of 2 alpha and 2 beta TFIIF subunits interacts directly with RNA ...

  2. NM_027016.2 → NP_081292.1  translocation protein SEC62 isoform 2

    See identical proteins and their annotated locations for NP_081292.1

    Status: VALIDATED

    Source sequence(s)
    AC158135, DV657309
    Consensus CDS
    CCDS17286.1
    UniProtKB/Swiss-Prot
    Q6NX81, Q8BU14
    Related
    ENSMUSP00000029256.8, ENSMUST00000029256.9
    Conserved Domains (1) summary
    pfam03839
    Location:170 → 292
    Sec62; Translocation protein Sec62

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    30847025..30875412
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BU14.1 GenPept UniProtKB/Swiss-Prot:Q8BU14

Gene LinkOut

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