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Sec62 SEC62 homolog, preprotein translocation [ Mus musculus (house mouse) ]

Gene ID: 69276, updated on 30-Apr-2024

Summary

Official Symbol
Sec62provided by MGI
Official Full Name
SEC62 homolog, preprotein translocationprovided by MGI
Primary source
MGI:MGI:1916526
See related
Ensembl:ENSMUSG00000027706 AllianceGenome:MGI:1916526
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HTP1; Dtrp1; Tloc1; 3100002M17Rik
Summary
Predicted to be involved in posttranslational protein targeting to membrane, translocation. Predicted to act upstream of or within posttranslational protein targeting to endoplasmic reticulum membrane. Predicted to be integral component of endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum and membrane. Orthologous to human SEC62 (SEC62 homolog, preprotein translocation factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 31.7), frontal lobe adult (RPKM 26.4) and 27 other tissues See more
Orthologs
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Genomic context

See Sec62 in Genome Data Viewer
Location:
3 A3; 3 14.29 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (30847025..30875412)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (30792876..30821263)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 31 Neighboring gene predicted gene 15462 Neighboring gene STARR-seq mESC enhancer starr_07301 Neighboring gene sterile alpha motif domain containing 7 Neighboring gene predicted gene, 33590 Neighboring gene predicted gene, 42198 Neighboring gene predicted gene, 42199 Neighboring gene G protein-coupled receptor 160

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
translocation protein SEC62
Names
SEC62 homolog
TP-1
translocation protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357528.1NP_001344457.1  translocation protein SEC62 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC158135
    Conserved Domains (2) summary
    pfam03839
    Location:170304
    Sec62; Translocation protein Sec62
    cl27000
    Location:290369
    TFIIFa; Transcription initiation factor IIF, alpha subunit, N-terminal region of RAP74. Subunit of transcription initiation complex involved in initiation, elongation and promoter escape.Tetramer of 2 alpha and 2 beta TFIIF subunits interacts directly with RNA ...
  2. NM_027016.2NP_081292.1  translocation protein SEC62 isoform 2

    See identical proteins and their annotated locations for NP_081292.1

    Status: VALIDATED

    Source sequence(s)
    AC158135, DV657309
    Consensus CDS
    CCDS17286.1
    UniProtKB/Swiss-Prot
    Q6NX81, Q8BU14
    Related
    ENSMUSP00000029256.8, ENSMUST00000029256.9
    Conserved Domains (1) summary
    pfam03839
    Location:170292
    Sec62; Translocation protein Sec62

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    30847025..30875412
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)