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TIMP2 TIMP metallopeptidase inhibitor 2 [ Homo sapiens (human) ]

Gene ID: 7077, updated on 6-Nov-2022

Summary

Official Symbol
TIMP2provided by HGNC
Official Full Name
TIMP metallopeptidase inhibitor 2provided by HGNC
Primary source
HGNC:HGNC:11821
See related
Ensembl:ENSG00000035862 MIM:188825; AllianceGenome:HGNC:11821
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DDC8; CSC-21K
Summary
This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 542.4), endometrium (RPKM 302.2) and 21 other tissues See more
Orthologs
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Genomic context

See TIMP2 in Genome Data Viewer
Location:
17q25.3
Exon count:
5
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (78852977..78925387, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (79747776..79820220, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (76849059..76921469, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 36 Neighboring gene uncharacterized LOC124904067 Neighboring gene ribosomal protein L9 pseudogene 29 Neighboring gene uncharacterized LOC124904068 Neighboring gene Sharpr-MPRA regulatory region 3779 Neighboring gene Sharpr-MPRA regulatory region 5911/8204 Neighboring gene CEP295 N-terminal like Neighboring gene Sharpr-MPRA regulatory region 6708 Neighboring gene galectin 3 binding protein Neighboring gene calcium activated nucleotidase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease.
EBI GWAS Catalog
Genome-wide association study of chronic periodontitis in a general German population.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog
Wnt signaling and Dupuytren's disease.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat induced monocyte invasion is inhibited by anti-beta integrin Ab or tissue inhibitor of metalloproteinase (TIMP), indicating an interaction with beta integrins and TIMP PubMed
tat HIV-1 Tat downregulates both basal and bFGF-induced secretion of TIMP-1 and TIMP-2, an effect involved in the Tat and bFGF induced increase in MMP-2 secretion PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metalloendopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables molecular function inhibitor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables peptidase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protease binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protease binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in negative regulation of endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of membrane protein ectodomain proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of metallopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to cytokine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to hormone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to organic substance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix HDA PubMed 
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
 
located_in specific granule lumen TAS
Traceable Author Statement
more info
 
located_in tertiary granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
metalloproteinase inhibitor 2
Names
testicular secretory protein Li 57
tissue inhibitor of metalloproteinases 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003255.5NP_003246.1  metalloproteinase inhibitor 2 precursor

    See identical proteins and their annotated locations for NP_003246.1

    Status: REVIEWED

    Source sequence(s)
    AC022966, AC100788, AL110197, BC052605
    Consensus CDS
    CCDS11758.1
    UniProtKB/Swiss-Prot
    P16035, Q9UDF7
    UniProtKB/TrEMBL
    A0A140VK57
    Related
    ENSP00000262768.6, ENST00000262768.11
    Conserved Domains (1) summary
    cd03585
    Location:27209
    NTR_TIMP; NTR domain, TIMP subfamily; TIMPs, or tissue inibitors of metalloproteases, are essential regulators of extracellular matrix turnover and remodeling. They form complexes with matrix metalloproteases (MMPs) and inactivate them irreversibly by ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    78852977..78925387 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    79747776..79820220 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)