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Timp2 tissue inhibitor of metalloproteinase 2 [ Mus musculus (house mouse) ]

Gene ID: 21858, updated on 14-May-2019

Summary

Official Symbol
Timp2provided by MGI
Official Full Name
tissue inhibitor of metalloproteinase 2provided by MGI
Primary source
MGI:MGI:98753
See related
Ensembl:ENSMUSG00000017466
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Timp-2; D11Bwg1104e
Expression
Broad expression in bladder adult (RPKM 237.6), lung adult (RPKM 168.3) and 23 other tissues See more
Orthologs

Genomic context

See Timp2 in Genome Data Viewer
Location:
11 E2; 11 83.09 cM
Exon count:
5
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (118301061..118355411, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (118162375..118216725, complement)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene cytohesin 1 Neighboring gene ubiquitin specific peptidase 36 Neighboring gene CEP295 N-terminal like Neighboring gene lectin, galactoside-binding, soluble, 3 binding protein Neighboring gene calcium activated nucleotidase 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enzyme activator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enzyme inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
integrin binding IDA
Inferred from Direct Assay
more info
PubMed 
integrin binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
metalloendopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metalloendopeptidase inhibitor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
metalloendopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
metalloendopeptidase inhibitor activity TAS
Traceable Author Statement
more info
PubMed 
peptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
protease binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protease binding ISO
Inferred from Sequence Orthology
more info
 
zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cellular response to organic substance IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of membrane protein ectodomain proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of metallopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
negative regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of proteolysis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of adenylate cyclase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
regulation of Rap protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
regulation of neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to cytokine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to hormone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to organic substance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
basement membrane IDA
Inferred from Direct Assay
more info
PubMed 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cell surface ISO
Inferred from Sequence Orthology
more info
 
extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space HDA PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
growth cone ISO
Inferred from Sequence Orthology
more info
 
neuron projection ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
metalloproteinase inhibitor 2
Names
tissue inhibitor of metalloproteinases 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011594.3NP_035724.2  metalloproteinase inhibitor 2 precursor

    See identical proteins and their annotated locations for NP_035724.2

    Status: VALIDATED

    Source sequence(s)
    AK032818, AK081522, BQ030835
    Consensus CDS
    CCDS25699.1
    UniProtKB/TrEMBL
    Q6PI17, Q8BSJ3
    Related
    ENSMUSP00000017610.3, ENSMUST00000017610.9
    Conserved Domains (1) summary
    cd03585
    Location:27209
    NTR_TIMP; NTR domain, TIMP subfamily; TIMPs, or tissue inibitors of metalloproteases, are essential regulators of extracellular matrix turnover and remodeling. They form complexes with matrix metalloproteases (MMPs) and inactivate them irreversibly by ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

    Range
    118301061..118355411 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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