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J Clin Periodontol. 2013 Nov;40(11):977-85. doi: 10.1111/jcpe.12154. Epub 2013 Sep 11.

Genome-wide association study of chronic periodontitis in a general German population.

Author information

1
Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany.

Abstract

AIM:

To identify loci associated with chronic periodontitis through a genome-wide association study (GWAS).

MATERIALS AND METHODS:

A GWAS was performed in 4032 individuals of two independent cross-sectional studies of West Pomerania (SHIP n = 3365 and SHIP-TREND n = 667) with different periodontal case definitions. Samples were genotyped with the Affymetrix Genome-Wide Human SNP Array 6.0 or the Illumina Human Omni 2.5 array. Imputation of the HapMap as well as the 1000 Genome-based autosomal and X-chromosomal genotypes and short insertions and deletions (INDELs) was performed in both cohorts. Finally, more than 17 million SNPs and short INDELs were analysed.

RESULTS:

No genome-wide significant associations were found for any periodontitis case definition, regardless of whether individuals aged >60 years where excluded or not. Despite no single SNP association reached genome-wide significance, the proportion of variance explained by additive effects of all common SNPs was around 23% for mean proximal attachment loss. Excluding subjects aged >60 years increased the explained variance to 34%.

CONCLUSIONS:

No single SNPs were found to be genome-wide significantly associated with chronic periodontitis in this study.

KEYWORDS:

Study of Health in Pomerania; attachment loss; genome-wide association studies; periodontitis

PMID:
24024966
DOI:
10.1111/jcpe.12154
[Indexed for MEDLINE]

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