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TIE1 tyrosine kinase with immunoglobulin like and EGF like domains 1 [ Homo sapiens (human) ]

Gene ID: 7075, updated on 9-Sep-2018

Summary

Official Symbol
TIE1provided by HGNC
Official Full Name
tyrosine kinase with immunoglobulin like and EGF like domains 1provided by HGNC
Primary source
HGNC:HGNC:11809
See related
Ensembl:ENSG00000066056 MIM:600222; Vega:OTTHUMG00000007282
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TIE; JTK14
Summary
This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Expression
Broad expression in placenta (RPKM 23.3), fat (RPKM 19.2) and 21 other tissues See more
Orthologs

Genomic context

See TIE1 in Genome Data Viewer
Location:
1p34.2
Exon count:
24
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (43300895..43323110)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (43766566..43788781)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene transmembrane protein 125 Neighboring gene chromosome 1 open reading frame 210 Neighboring gene MPL proto-oncogene, thrombopoietin receptor Neighboring gene uncharacterized LOC105378687

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
mesoderm development TAS
Traceable Author Statement
more info
PubMed 
negative regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
negative regulation of signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
plasma membrane fusion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to retinoic acid IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
vasculogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
tyrosine-protein kinase receptor Tie-1
Names
tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 1
NP_001240286.1
NP_005415.1
XP_005271220.1
XP_006710932.1
XP_016857696.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030673.1 RefSeqGene

    Range
    5001..27216
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001253357.1NP_001240286.1  tyrosine-protein kinase receptor Tie-1 isoform 2

    See identical proteins and their annotated locations for NP_001240286.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK300399, BM970991, DB287371, R13130
    UniProtKB/TrEMBL
    B4DTW8
    Conserved Domains (7) summary
    smart00219
    Location:7941062
    TyrKc; Tyrosine kinase, catalytic domain
    cd00054
    Location:182211
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00063
    Location:599691
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05089
    Location:7911087
    PTKc_Tie1; Catalytic domain of the Protein Tyrosine Kinase, Tie1
    pfam00041
    Location:503587
    fn3; Fibronectin type III domain
    pfam00047
    Location:84165
    ig; Immunoglobulin domain
    pfam07974
    Location:270299
    EGF_2; EGF-like domain
  2. NM_005424.4NP_005415.1  tyrosine-protein kinase receptor Tie-1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_005415.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC038239, BM970991, DB287371, R13130
    Consensus CDS
    CCDS482.1
    UniProtKB/Swiss-Prot
    P35590
    Related
    ENSP00000361554.3, OTTHUMP00000008352, ENST00000372476.7, OTTHUMT00000019011
    Conserved Domains (7) summary
    smart00219
    Location:8391107
    TyrKc; Tyrosine kinase, catalytic domain
    cd00054
    Location:227256
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00063
    Location:644736
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05089
    Location:8361132
    PTKc_Tie1; Catalytic domain of the Protein Tyrosine Kinase, Tie1
    pfam00041
    Location:548632
    fn3; Fibronectin type III domain
    pfam00047
    Location:129210
    ig; Immunoglobulin domain
    pfam07974
    Location:315344
    EGF_2; EGF-like domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    43300895..43323110
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005271163.2XP_005271220.1  tyrosine-protein kinase receptor Tie-1 isoform X1

    Conserved Domains (6) summary
    smart00219
    Location:7961064
    TyrKc; Tyrosine kinase, catalytic domain
    cd00055
    Location:227265
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00063
    Location:601693
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05089
    Location:7931089
    PTKc_Tie1; Catalytic domain of the Protein Tyrosine Kinase, Tie1
    pfam00041
    Location:505589
    fn3; Fibronectin type III domain
    pfam00047
    Location:129210
    ig; Immunoglobulin domain
  2. XM_017002207.2XP_016857696.1  tyrosine-protein kinase receptor Tie-1 isoform X2

    Conserved Domains (6) summary
    smart00410
    Location:369443
    IG_like; Immunoglobulin like
    cd00054
    Location:227256
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00063
    Location:644736
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:548632
    fn3; Fibronectin type III domain
    pfam00047
    Location:129210
    ig; Immunoglobulin domain
    pfam07974
    Location:315344
    EGF_2; EGF-like domain
  3. XM_006710869.1XP_006710932.1  tyrosine-protein kinase receptor Tie-1 isoform X3

    Conserved Domains (6) summary
    smart00219
    Location:484752
    TyrKc; Tyrosine kinase, catalytic domain
    smart00410
    Location:1488
    IG_like; Immunoglobulin like
    cd00063
    Location:289381
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:193277
    fn3; Fibronectin type III domain
    pfam00047
    Location:186
    ig; Immunoglobulin domain
    cl21453
    Location:481777
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_946751.2 RNA Sequence

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