MYLIP myosin regulatory light chain interacting protein [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Official Symbol: MYLIPprovided by VGNC
Official Full Name: myosin regulatory light chain interacting proteinprovided by VGNC
Primary source: VGNC:VGNC:75000
See related: Ensembl:ENSMMUG00000057657
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
103	current	Mmul_10 (GCF_003339765.1)	4	NC_041757.1 (153851637..153870757, complement)
102	previous assembly	Mmul_8.0.1 (GCF_000772875.2)	4	NC_027896.1 (16435614..16454603)

Chromosome 4 - NC_041757.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

WI-14205 (e-PCR)
- UniSTS:66586

A004C26 (e-PCR)
- UniSTS:45372

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables cytoskeletal protein binding	IEA Inferred from Electronic Annotation more info	PubMed
enables ubiquitin-protein transferase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: E3 ubiquitin-protein ligase MYLIP

NP_001248724.1

EC 2.3.2.27

EC 6.3.2.-

XP_014991041.1

EC 2.3.2.27

EC 6.3.2.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001261795.2 → NP_001248724.1 E3 ubiquitin-protein ligase MYLIP

See identical proteins and their annotated locations for NP_001248724.1

Status: PROVISIONAL

Source sequence(s)

JV045677

UniProtKB/TrEMBL

F6QA16, G7MQS4, H9ES76

Related

ENSMMUP00000065793.1, ENSMMUT00000083192.1

Conserved Domains (5) summary

smart00295
Location:5 → 190

B41; Band 4.1 homologues

cd13195
Location:185 → 295

FERM_C_MYLIP_IDOL; FERM domain C-lobe of E3 ubiquitin ligase myosin regulatory light chain-interacting protein (MYLIP; also called inducible degrader of the LDL receptor, IDOL)

pfam00373
Location:85 → 190

FERM_M; FERM central domain

pfam09379
Location:5 → 67

FERM_N; FERM N-terminal domain

pfam13920
Location:383 → 428

zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

NC_041757.1 Reference Mmul_10 Primary Assembly

Range

153851637..153870757 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_015135555.2 → XP_014991041.1 E3 ubiquitin-protein ligase MYLIP isoform X1

UniProtKB/TrEMBL

G7MQS4

Conserved Domains (5) summary

smart00295
Location:5 → 135

B41; Band 4.1 homologues

pfam00373
Location:85 → 140

FERM_M; FERM central domain

pfam09379
Location:5 → 67

FERM_N; FERM N-terminal domain

pfam13920
Location:317 → 362

zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

cl17171
Location:154 → 229

PH-like; Pleckstrin homology-like domain