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Mylip myosin regulatory light chain interacting protein [ Mus musculus (house mouse) ]

Gene ID: 218203, updated on 18-Apr-2024

Summary

Official Symbol
Mylipprovided by MGI
Official Full Name
myosin regulatory light chain interacting proteinprovided by MGI
Primary source
MGI:MGI:2388271
See related
Ensembl:ENSMUSG00000038175 AllianceGenome:MGI:2388271
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mir; 9430057C20Rik
Summary
Enables ubiquitin protein ligase activity. Involved in several processes, including cholesterol homeostasis; negative regulation of low-density lipoprotein particle clearance; and regulation of protein catabolic process. Predicted to be located in cytoplasm; cytoskeleton; and plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human MYLIP (myosin regulatory light chain interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 23.3), mammary gland adult (RPKM 20.8) and 27 other tissues See more
Orthologs
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Genomic context

Location:
13 A5; 13 21.88 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (45543197..45565498)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (45389742..45411940)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_34389 Neighboring gene predicted gene, 34466 Neighboring gene STARR-seq mESC enhancer starr_34390 Neighboring gene STARR-seq mESC enhancer starr_34392 Neighboring gene predicted gene, 40933 Neighboring gene STARR-positive B cell enhancer ABC_E1462 Neighboring gene STARR-seq mESC enhancer starr_34393 Neighboring gene STARR-positive B cell enhancer ABC_E5392 Neighboring gene predicted gene, 53792 Neighboring gene STARR-positive B cell enhancer ABC_E7232 Neighboring gene guanosine monophosphate reductase Neighboring gene predicted gene, 34582

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (6)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC11702

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytoskeletal protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin-protein transferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase MYLIP
Names
RING-type E3 ubiquitin transferase MYLIP
idol
inducible degrader of the LDL-receptor
NP_722484.2
XP_036013884.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153789.3NP_722484.2  E3 ubiquitin-protein ligase MYLIP

    See identical proteins and their annotated locations for NP_722484.2

    Status: PROVISIONAL

    Source sequence(s)
    AC154521
    Consensus CDS
    CCDS36648.1
    UniProtKB/Swiss-Prot
    Q3TX01, Q8BLY9, Q8BM54, Q91Z47
    UniProtKB/TrEMBL
    Q3TAE7
    Related
    ENSMUSP00000047403.10, ENSMUST00000038275.11
    Conserved Domains (5) summary
    smart00295
    Location:5190
    B41; Band 4.1 homologues
    cd13195
    Location:185295
    FERM_C_MYLIP_IDOL; FERM domain C-lobe of E3 ubiquitin ligase myosin regulatory light chain-interacting protein (MYLIP; also called inducible degrader of the LDL receptor, IDOL)
    pfam00373
    Location:85190
    FERM_M; FERM central domain
    pfam09379
    Location:567
    FERM_N; FERM N-terminal domain
    pfam13920
    Location:383428
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    45543197..45565498
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157991.1XP_036013884.1  E3 ubiquitin-protein ligase MYLIP isoform X1

    Conserved Domains (2) summary
    cd13195
    Location:4114
    FERM_C_MYLIP_IDOL; FERM domain C-lobe of E3 ubiquitin ligase myosin regulatory light chain-interacting protein (MYLIP; also called inducible degrader of the LDL receptor, IDOL)
    cd16523
    Location:205242
    RING-HC_MYLIP; RING finger, HC subclass, found in myosin regulatory light chain interacting protein (MYLIP) and similar proteins