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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_009616.1 RefSeqGene
- Range
-
429..41778
- Download
- GenBank, FASTA, Sequence Viewer (Graphics), LRG_128
mRNA and Protein(s)
-
NM_000061.3 → NP_000052.1 tyrosine-protein kinase BTK isoform 1
See identical proteins and their annotated locations for NP_000052.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) encodes isoform 1.
- Source sequence(s)
-
AK057105, BC109079, DA619542, DB636737
- Consensus CDS
-
CCDS14482.1
- UniProtKB/Swiss-Prot
-
Q06187
- UniProtKB/TrEMBL
-
Q5JY90
- Related
- ENSP00000308176.7, ENST00000308731.7
- Conserved Domains (4) summary
-
- cd05113
Location:397 → 652
- PTKc_Btk_Bmx; Catalytic domain of the Protein Tyrosine Kinases, Bruton's tyrosine kinase and Bone marrow kinase on the X chromosome
- cd10397
Location:274 → 379
- SH2_Tec_Btk; Src homology 2 (SH2) domain found in Tec protein, Bruton's tyrosine kinase (Btk)
- cd11906
Location:217 → 271
- SH3_BTK; Src Homology 3 domain of Bruton's tyrosine kinase
- cd01238
Location:6 → 166
- PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
-
NM_001287344.2 → NP_001274273.1 tyrosine-protein kinase BTK isoform 3
See identical proteins and their annotated locations for NP_001274273.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) differs in the 5' UTR and CDS, and represents the use of an alternate promoter, compared to variant 1. The resulting protein (isoform 3) has a longer N-terminus, compared to isoform 1.
- Source sequence(s)
-
AK309851, AV733045, DB331677, DB636737
- Consensus CDS
-
CCDS76003.1
- UniProtKB/Swiss-Prot
-
Q06187
- Related
- ENSP00000483570.1, ENST00000621635.4
- Conserved Domains (6) summary
-
- cd05113
Location:431 → 686
- PTKc_Btk_Bmx; Catalytic domain of the Protein Tyrosine Kinases, Bruton's tyrosine kinase and Bone marrow kinase on the X chromosome
- cd10397
Location:308 → 413
- SH2_Tec_Btk; Src homology 2 (SH2) domain found in Tec protein, Bruton's tyrosine kinase (Btk)
- cd11906
Location:251 → 305
- SH3_BTK; Src Homology 3 domain of Bruton's tyrosine kinase
- cd01238
Location:40 → 200
- PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
- pfam00169
Location:38 → 167
- PH; PH domain
- pfam07714
Location:436 → 685
- Pkinase_Tyr; Protein tyrosine kinase
-
NM_001287345.2 → NP_001274274.1 tyrosine-protein kinase BTK isoform 2
See identical proteins and their annotated locations for NP_001274274.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR and lacks several exons in the 3' CDS compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1.
- Source sequence(s)
-
AK057105, AL035422, AU107296, BC109079, DA619542
- Consensus CDS
-
CCDS76002.1
- UniProtKB/Swiss-Prot
-
Q06187
- UniProtKB/TrEMBL
-
Q5JY90
- Related
- ENSP00000361971.1, ENST00000372880.5
- Conserved Domains (4) summary
-
- cd11906
Location:217 → 271
- SH3_BTK; Src Homology 3 domain of Bruton's tyrosine kinase
- cd01238
Location:6 → 166
- PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
- cl15255
Location:274 → 350
- SH2; Src homology 2 (SH2) domain
- cl21453
Location:346 → 476
- PKc_like; Protein Kinases, catalytic domain
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p13 Primary Assembly
Genomic
-
NC_000023.11 Reference GRCh38.p13 Primary Assembly
- Range
-
101349450..101390796 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)