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MLX MAX dimerization protein MLX [ Homo sapiens (human) ]

Gene ID: 6945, updated on 7-Jun-2020

Summary

Official Symbol
MLXprovided by HGNC
Official Full Name
MAX dimerization protein MLXprovided by HGNC
Primary source
HGNC:HGNC:11645
See related
Ensembl:ENSG00000108788 MIM:602976
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TF4; MAD7; MXD7; TCFL4; bHLHd13
Summary
The product of this gene belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. These factors form heterodimers with Mad proteins and play a role in proliferation, determination and differentiation. This gene product may act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors, namely, Mad1 and Mad4. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in duodenum (RPKM 29.5), small intestine (RPKM 29.2) and 25 other tissues See more
Orthologs

Genomic context

See MLX in Genome Data Viewer
Location:
17q21.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (42567060..42573203)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (40719078..40725221)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene HSD17B1 promoter Neighboring gene uncharacterized LOC108783654 Neighboring gene hydroxysteroid 17-beta dehydrogenase 1 Neighboring gene Coenzyme A synthase Neighboring gene PSMC3 interacting protein Neighboring gene reticulophagy regulator family member 3 Neighboring gene tubulin gamma 1 Neighboring gene CRISPRi-validated cis-regulatory element chr17.2672

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nuclear membrane IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
max-like protein X
Names
BigMax protein
MAX-like bHLHZIP protein
MLX, MAX dimerization protein
class D basic helix-loop-helix protein 13
transcription factor-like protein 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029442.1 RefSeqGene

    Range
    5001..11144
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_170607.2NP_733752.1  max-like protein X isoform gamma

    See identical proteins and their annotated locations for NP_733752.1

    Status: REVIEWED

    Source sequence(s)
    AA024982, AF203978, AF213668, BC010689, BE907687, BI517590, BQ186038
    Consensus CDS
    CCDS11430.1
    UniProtKB/Swiss-Prot
    Q9UH92
    Related
    ENSP00000246912.3, ENST00000246912.8
    Conserved Domains (1) summary
    pfam00010
    Location:130188
    HLH; Helix-loop-helix DNA-binding domain
  2. NM_198204.2NP_937847.1  max-like protein X isoform beta

    See identical proteins and their annotated locations for NP_937847.1

    Status: REVIEWED

    Source sequence(s)
    AC067852
    Consensus CDS
    CCDS45687.1
    UniProtKB/Swiss-Prot
    Q9UH92
    Related
    ENSP00000416627.1, ENST00000435881.6
    Conserved Domains (1) summary
    pfam00010
    Location:76134
    HLH; Helix-loop-helix DNA-binding domain
  3. NM_198205.1NP_937848.1  max-like protein X isoform alpha

    See identical proteins and their annotated locations for NP_937848.1

    Status: REVIEWED

    Source sequence(s)
    AA024982, AF203978, AF213668, BC010689, BE907687, BI517590, BQ186038
    Consensus CDS
    CCDS42341.1
    UniProtKB/Swiss-Prot
    Q9UH92
    Related
    ENSP00000320913.3, ENST00000346833.8
    Conserved Domains (1) summary
    pfam00010
    Location:46104
    HLH; Helix-loop-helix DNA-binding domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    42567060..42573203
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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