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SURF2 surfeit 2 [ Homo sapiens (human) ]

Gene ID: 6835, updated on 1-Jun-2020

Summary

Official Symbol
SURF2provided by HGNC
Official Full Name
surfeit 2provided by HGNC
Primary source
HGNC:HGNC:11475
See related
Ensembl:ENSG00000148291 MIM:185630
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SURF-2
Summary
This gene shares a bidirectional promoter with surfeit 1 (SURF1; GeneID: 6834), which is located on the opposite strand. It encodes a conserved protein that is expressed in a variety of tissues. [provided by RefSeq, Jul 2013]
Expression
Broad expression in testis (RPKM 30.3), kidney (RPKM 8.2) and 25 other tissues See more
Orthologs

Genomic context

See SURF2 in Genome Data Viewer
Location:
9q34.2
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (133356550..133361158)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (136223421..136228041)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, C/D box 36C Neighboring gene ribosomal protein L7a Neighboring gene SURF1 cytochrome c oxidase assembly factor Neighboring gene surfeit 4 Neighboring gene serine/threonine kinase like domain containing 1 Neighboring gene REX4 homolog, 3'-5' exonuclease Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 13

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: STKLD1

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
nuclear speck IDA
Inferred from Direct Assay
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278928.2NP_001265857.1  surfeit locus protein 2 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    BI118187, BP244646, Z35094
    UniProtKB/Swiss-Prot
    Q15527
    Conserved Domains (1) summary
    pfam05477
    Location:5240
    SURF2; Surfeit locus protein 2 (SURF2)
  2. NM_017503.5NP_059973.4  surfeit locus protein 2 isoform 1

    See identical proteins and their annotated locations for NP_059973.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC014411, BP244646
    Consensus CDS
    CCDS6967.1
    UniProtKB/Swiss-Prot
    Q15527
    Related
    ENSP00000361032.4, ENST00000371964.5
    Conserved Domains (1) summary
    pfam05477
    Location:5241
    SURF2; Surfeit locus protein 2 (SURF2)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    133356550..133361158
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_009646201.1 Reference GRCh38.p13 PATCHES

    Range
    182644..187252
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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