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SURF2 surfeit 2 [ Homo sapiens (human) ]

Gene ID: 6835, updated on 3-Mar-2026
Official Symbol
SURF2provided by HGNC
Official Full Name
surfeit 2provided by HGNC
Primary source
HGNC:HGNC:11475
See related
Ensembl:ENSG00000148291 MIM:185630; AllianceGenome:HGNC:11475
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SURF-2
Summary
This gene shares a bidirectional promoter with surfeit 1 (SURF1; GeneID: 6834), which is located on the opposite strand. It encodes a conserved protein that is expressed in a variety of tissues. [provided by RefSeq, Jul 2013]
Expression
Broad expression in testis (RPKM 30.3), kidney (RPKM 8.2) and 25 other tissues See more
Orthologs
all
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Try the new Transcripts and proteins table
See SURF2 in Genome Data Viewer
Location:
9q34.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (133356550..133361158)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (145570504..145575112)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (136223426..136228034)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20452 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20453 Neighboring gene small nucleolar RNA, C/D box 36C Neighboring gene ribosomal protein L7a Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29237 Neighboring gene SURF1 cytochrome c oxidase assembly factor Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136234564-136235235 Neighboring gene surfeit 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20454 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20455 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20456 Neighboring gene serine/threonine kinase like domain containing 1 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr9:136257045-136257682 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136265498-136266135 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:136267839-136268006 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136269742-136270242 Neighboring gene RNA exonuclease 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20457 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29238 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 13

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. The Surf-1 and Surf-2 genes and their essential bidirectional promoter elements are conserved between mouse and human. Lennard A, et al. DNA Cell Biol, 1994 Nov. PMID 7702754
  2. The human Surfeit locus. Duhig T, et al. Genomics, 1998 Aug 15. PMID 9740673
  3. The organization and conservation of the human Surfeit gene cluster and its localization telomeric to the c-abl and can proto-oncogenes at chromosome band 9q34.1. Yon J, et al. Hum Mol Genet, 1993 Mar. PMID 8499913
  4. Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease. Tang W, et al. Am J Hum Genet, 2012 Jul 13. PMID 22703881, Free PMC Article
  5. The telomeric protein AKTIP interacts with A- and B-type lamins and is involved in regulation of cellular senescence. Burla R, et al. Open Biol, 2016 Aug. PMID 27512140, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  2. Observational study of gene-disease association. (HuGE Navigator)
    Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease.
EBI GWAS Catalog

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Potential readthrough

Included gene: STKLD1

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Preferred Names
surfeit locus protein 2

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278928.2 → NP_001265857.1  surfeit locus protein 2 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    BI118187, BP244646, Z35094
    UniProtKB/Swiss-Prot
    Q15527
    Related
    ENSP00000545794.1, ENST00000875735.1
    Conserved Domains (1) summary
    pfam05477
    Location:5 → 240
    SURF2; Surfeit locus protein 2 (SURF2)

  2. NM_017503.5 → NP_059973.4  surfeit locus protein 2 isoform 1

    See identical proteins and their annotated locations for NP_059973.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC014411, BP244646
    Consensus CDS
    CCDS6967.1
    UniProtKB/Swiss-Prot
    Q15527, Q6IBP9, Q96CD1
    Related
    ENSP00000361032.4, ENST00000371964.5
    Conserved Domains (1) summary
    pfam05477
    Location:5 → 241
    SURF2; Surfeit locus protein 2 (SURF2)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    133356550..133361158
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_009646201.1 Reference GRCh38.p14 PATCHES

    Range
    182644..187252
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    145570504..145575112
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q15527.4 GenPept UniProtKB/Swiss-Prot:Q15527

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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