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STK4 serine/threonine kinase 4 [ Homo sapiens (human) ]

Gene ID: 6789, updated on 9-May-2021

Summary

Official Symbol
STK4provided by HGNC
Official Full Name
serine/threonine kinase 4provided by HGNC
Primary source
HGNC:HGNC:11408
See related
Ensembl:ENSG00000101109 MIM:604965
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KRS2; MST1; YSK3
Summary
The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process. [provided by RefSeq, Jul 2008]
Annotation information
Note: MST1 (Gene ID: 4485) and STK4 (Gene ID: 6789) share the MST1 symbol/alias in common. MST1 is a widely used alternative name for serine/threonine kinase 4 (STK4), which can be confused with the official symbol for macrophage stimulating 1 (MST1). [01 Jun 2018]
Expression
Broad expression in lymph node (RPKM 17.1), appendix (RPKM 14.6) and 24 other tissues See more
Orthologs
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Genomic context

See STK4 in Genome Data Viewer
Location:
20q13.12
Exon count:
17
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (44966470..45080021)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (43595153..43708662)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene translocase of outer mitochondrial membrane 34 Neighboring gene STK4 antisense RNA 1 (head to head) Neighboring gene potassium voltage-gated channel modifier subfamily S member 1 Neighboring gene WAP four-disulfide core domain 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp686A2068

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activator activity TAS
Traceable Author Statement
more info
PubMed 
enables protein serine/threonine kinase activity EXP
Inferred from Experiment
more info
PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in activation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in branching involved in blood vessel morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in cell differentiation involved in embryonic placenta development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in central nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in endocardium development IEA
Inferred from Electronic Annotation
more info
 
involved_in hepatocyte apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in hippo signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in hippo signaling TAS
Traceable Author Statement
more info
PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in keratinocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of organ growth IEA
Inferred from Electronic Annotation
more info
 
involved_in neural tube formation IEA
Inferred from Electronic Annotation
more info
 
involved_in peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of protein binding IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of substrate-dependent cell migration, cell attachment to substrate IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of vascular associated smooth muscle cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in primitive hemopoiesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within protein stabilization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein tetramerization IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of cell differentiation involved in embryonic placenta development IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nuclear body IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase 4
Names
STE20-like kinase MST1
hippo homolog
kinase responsive to stress 2
mammalian STE20-like protein kinase 1
mammalian sterile 20-like 1
serine/threonine-protein kinase Krs-2
NP_001339314.1
NP_006273.1
XP_005260587.1
XP_005260588.1
XP_005260589.1
XP_011527320.1
XP_011527322.1
XP_016883518.1
XP_016883519.1
XP_016883520.1
XP_016883521.1
XP_016883522.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032172.1 RefSeqGene

    Range
    5001..118475
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_535

mRNA and Protein(s)

  1. NM_001352385.2NP_001339314.1  serine/threonine-protein kinase 4 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AK027088, AL109839, BC038850, Z93016
    Consensus CDS
    CCDS86957.1
    Related
    ENSP00000361887.1, ENST00000372801.5
    Conserved Domains (1) summary
    cd06612
    Location:26281
    STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
  2. NM_006282.5NP_006273.1  serine/threonine-protein kinase 4 isoform 1

    See identical proteins and their annotated locations for NP_006273.1

    Status: REVIEWED

    Source sequence(s)
    AK027088, AL597960, U60207, Z93016
    Consensus CDS
    CCDS13341.1
    UniProtKB/Swiss-Prot
    Q13043
    Related
    ENSP00000361892.3, ENST00000372806.8
    Conserved Domains (3) summary
    cd06612
    Location:26281
    STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
    smart00220
    Location:30281
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam11629
    Location:433480
    Mst1_SARAH; C terminal SARAH domain of Mst1

RNA

  1. NR_147974.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL109839, BC039023
    Related
    ENST00000487587.2
  2. NR_147975.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL109839
    Related
    ENST00000488618.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    44966470..45080021
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017028030.2XP_016883519.1  serine/threonine-protein kinase 4 isoform X3

    Conserved Domains (3) summary
    cd06612
    Location:17268
    STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
    smart00220
    Location:24268
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam11629
    Location:420467
    Mst1_SARAH; C terminal SARAH domain of Mst1
  2. XM_017028033.2XP_016883522.1  serine/threonine-protein kinase 4 isoform X7

  3. XM_017028029.2XP_016883518.1  serine/threonine-protein kinase 4 isoform X3

    Conserved Domains (3) summary
    cd06612
    Location:17268
    STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
    smart00220
    Location:24268
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam11629
    Location:420467
    Mst1_SARAH; C terminal SARAH domain of Mst1
  4. XM_017028032.2XP_016883521.1  serine/threonine-protein kinase 4 isoform X4

    Conserved Domains (3) summary
    cd06612
    Location:4252
    STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
    smart00220
    Location:11252
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam11629
    Location:404451
    Mst1_SARAH; C terminal SARAH domain of Mst1
  5. XM_005260531.3XP_005260588.1  serine/threonine-protein kinase 4 isoform X2

    Conserved Domains (2) summary
    cd06612
    Location:42297
    STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
    smart00220
    Location:46297
    S_TKc; Serine/Threonine protein kinases, catalytic domain
  6. XM_005260530.2XP_005260587.1  serine/threonine-protein kinase 4 isoform X1

    Conserved Domains (3) summary
    cd06612
    Location:42297
    STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
    smart00220
    Location:46297
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam11629
    Location:449496
    Mst1_SARAH; C terminal SARAH domain of Mst1
  7. XM_011529020.2XP_011527322.1  serine/threonine-protein kinase 4 isoform X6

    Conserved Domains (2) summary
    cd06612
    Location:42297
    STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
    smart00220
    Location:46297
    S_TKc; Serine/Threonine protein kinases, catalytic domain
  8. XM_017028031.2XP_016883520.1  serine/threonine-protein kinase 4 isoform X3

    Conserved Domains (3) summary
    cd06612
    Location:17268
    STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
    smart00220
    Location:24268
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam11629
    Location:420467
    Mst1_SARAH; C terminal SARAH domain of Mst1
  9. XM_011529018.3XP_011527320.1  serine/threonine-protein kinase 4 isoform X5

    See identical proteins and their annotated locations for XP_011527320.1

    Conserved Domains (3) summary
    cd06612
    Location:1205
    STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
    smart00220
    Location:1205
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam11629
    Location:357404
    Mst1_SARAH; C terminal SARAH domain of Mst1
  10. XM_005260532.4XP_005260589.1  serine/threonine-protein kinase 4 isoform X3

    Conserved Domains (3) summary
    cd06612
    Location:17268
    STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
    smart00220
    Location:24268
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam11629
    Location:420467
    Mst1_SARAH; C terminal SARAH domain of Mst1
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