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SSR3 signal sequence receptor subunit 3 [ Homo sapiens (human) ]

Gene ID: 6747, updated on 5-Jul-2020

Summary

Official Symbol
SSR3provided by HGNC
Official Full Name
signal sequence receptor subunit 3provided by HGNC
Primary source
HGNC:HGNC:11325
See related
Ensembl:ENSG00000114850 MIM:606213
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TRAPG
Summary
The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR is comprised of four membrane proteins/subunits: alpha, beta, gamma, and delta. The first two are glycosylated subunits and the latter two are non-glycosylated subunits. This gene encodes the gamma subunit, which is predicted to span the membrane four times. [provided by RefSeq, Aug 2010]
Expression
Ubiquitous expression in thyroid (RPKM 48.0), endometrium (RPKM 38.4) and 25 other tissues See more
Orthologs

Genomic context

See SSR3 in Genome Data Viewer
Location:
3q25.31
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (156539553..156555200, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (156257929..156272973, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel subfamily A member regulatory beta subunit 1 Neighboring gene KCNAB1 antisense RNA 2 Neighboring gene KCNAB1 antisense RNA 1 Neighboring gene uncharacterized LOC107986148 Neighboring gene TIPARP antisense RNA 1 Neighboring gene TCDD inducible poly(ADP-ribose) polymerase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of signal sequence receptor, gamma (translocon-associated protein gamma; SSR3) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat Both HIV-1 Tat 47-59 and FITC-labeled Tat 47-59 peptides upregulate gene expression of signal sequence receptor, gamma (translocon-associated protein gamma; SSR3) in U-937 macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
SRP-dependent cotranslational protein targeting to membrane IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
translocon-associated protein subunit gamma
Names
SSR gamma
TRAP-complex gamma subunit
TRAP-gamma
signal sequence receptor subunit gamma
signal sequence receptor, gamma (translocon-associated protein gamma)
translocon-associated protein gamma subunit

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308197.1NP_001295126.1  translocon-associated protein subunit gamma isoform 1

    See identical proteins and their annotated locations for NP_001295126.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC092927, AI225105, AK304364, HY035536
    Consensus CDS
    CCDS77846.1
    UniProtKB/Swiss-Prot
    Q9UNL2
    Related
    ENSP00000420641.1, ENST00000467789.5
    Conserved Domains (1) summary
    pfam07074
    Location:12196
    TRAP-gamma; Translocon-associated protein, gamma subunit (TRAP-gamma)
  2. NM_001308204.1NP_001295133.1  translocon-associated protein subunit gamma isoform 3

    See identical proteins and their annotated locations for NP_001295133.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks a 5' exon, contains an alternate 5' terminal exon, uses a downstream start codon, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. It encodes isoform 3 which is shorter compared to isoform 1. Both variants 3 and 4 encode the same isoform (3).
    Source sequence(s)
    AC092927, AF110647, AI225105, BC017203, BJ997360, BM988383, BU532041, CN409041, CX786292, DA283706
    Consensus CDS
    CCDS82865.1
    UniProtKB/Swiss-Prot
    Q9UNL2
    UniProtKB/TrEMBL
    C9J365
    Related
    ENSP00000417306.1, ENST00000463503.5
    Conserved Domains (1) summary
    pfam07074
    Location:1131
    TRAP-gamma; Translocon-associated protein, gamma subunit (TRAP-gamma)
  3. NM_001308205.1NP_001295134.1  translocon-associated protein subunit gamma isoform 3

    See identical proteins and their annotated locations for NP_001295134.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks a 5' exon, contains an alternate 5' terminal exon, uses a downstream start codon, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. It encodes isoform 3 which is shorter compared to isoform 1. Both variants 3 and 4 encode the same isoform (3).
    Source sequence(s)
    AC092927, AF110647, AI225105, BC017203, BJ997360, BM988383, BU532041, CN409041, CX786292, DA725890
    Consensus CDS
    CCDS82865.1
    UniProtKB/Swiss-Prot
    Q9UNL2
    UniProtKB/TrEMBL
    C9J365
    Related
    ENSP00000420087.1, ENST00000496050.1
    Conserved Domains (1) summary
    pfam07074
    Location:1131
    TRAP-gamma; Translocon-associated protein, gamma subunit (TRAP-gamma)
  4. NM_007107.5NP_009038.1  translocon-associated protein subunit gamma isoform 2

    See identical proteins and their annotated locations for NP_009038.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region compared to variant 1. It encodes isoform 2 which is shorter compared to isoform 1.
    Source sequence(s)
    AC092927, AF110647, AI225105, BC017203, BJ997360, BM988383, BU532041, CN409041, CX786292, DA750309
    Consensus CDS
    CCDS3176.1
    UniProtKB/Swiss-Prot
    Q9UNL2
    Related
    ENSP00000265044.2, ENST00000265044.6
    Conserved Domains (1) summary
    pfam07074
    Location:12183
    TRAP-gamma; Translocon-associated protein, gamma subunit (TRAP-gamma)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    156539553..156555200 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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