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SPTAN1 spectrin alpha, non-erythrocytic 1 [ Homo sapiens (human) ]

Gene ID: 6709, updated on 6-Nov-2022

Summary

Official Symbol
SPTAN1provided by HGNC
Official Full Name
spectrin alpha, non-erythrocytic 1provided by HGNC
Primary source
HGNC:HGNC:11273
See related
Ensembl:ENSG00000197694 MIM:182810; AllianceGenome:HGNC:11273
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DEE5; NEAS; EIEE5; SPTA2
Summary
Spectrins are a family of filamentous cytoskeletal proteins that function as essential scaffold proteins that stabilize the plasma membrane and organize intracellular organelles. Spectrins are composed of alpha and beta dimers that associate to form tetramers linked in a head-to-head arrangement. This gene encodes an alpha spectrin that is specifically expressed in nonerythrocytic cells. The encoded protein has been implicated in other cellular functions including DNA repair and cell cycle regulation. Mutations in this gene are the cause of early infantile epileptic encephalopathy-5. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010]
Expression
Ubiquitous expression in brain (RPKM 87.7), testis (RPKM 42.9) and 24 other tissues See more
Orthologs
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Genomic context

See SPTAN1 in Genome Data Viewer
Location:
9q34.11
Exon count:
60
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (128552587..128633662)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (140759427..140840530)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (131314866..131395941)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene GLE1 RNA export mediator Neighboring gene uncharacterized LOC101929270 Neighboring gene RNA, U7 small nuclear 171 pseudogene Neighboring gene Sharpr-MPRA regulatory region 290 Neighboring gene dynein 2 intermediate chain 2 Neighboring gene vesicle transport through interaction with t-SNAREs 1B pseudogene 4 Neighboring gene high mobility group AT-hook 1 pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Developmental and epileptic encephalopathy, 5
MedGen: C3150731 OMIM: 613477 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.
EBI GWAS Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of spectrin, alpha, non-erythrocytic 1 (SPTAN1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify spectrin alpha chain (SPTAN1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify spectrin alpha chain (SPTAN1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify spectrin alpha chain (SPTAN1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify spectrin alpha chain (SPTAN1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Rev rev HIV-1 Rev interacting protein, spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) (SPTAN1), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed
Vpr vpr HIV-1 Vpr upregulates SPTAN1 in HeLa cells within 12 hours of exposure PubMed
retropepsin gag-pol A number of focal adhesion plaque proteins are specifically cleaved by HIV-1 protease, including fimbrin, focal adhesion plaque kinase (FAK), talin, and, to a lesser extent, filamin, spectrin and fibronectin PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ17738, FLJ44613

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin binding TAS
Traceable Author Statement
more info
PubMed 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cadherin binding HDA PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural constituent of cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in actin filament capping IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cell junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cell projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cortical actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in extracellular vesicle HDA PubMed 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in membrane TAS
Traceable Author Statement
more info
PubMed 
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in specific granule lumen TAS
Traceable Author Statement
more info
 
part_of spectrin TAS
Traceable Author Statement
more info
PubMed 
located_in tertiary granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
spectrin alpha chain, non-erythrocytic 1
Names
alpha-II spectrin
alpha-fodrin
epididymis secretory sperm binding protein
fodrin alpha chain
spectrin, non-erythroid alpha chain
spectrin, non-erythroid alpha subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027748.2 RefSeqGene

    Range
    5002..86077
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001130438.3NP_001123910.1  spectrin alpha chain, non-erythrocytic 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL356481
    Consensus CDS
    CCDS48036.1
    UniProtKB/Swiss-Prot
    Q13813
    Related
    ENSP00000361824.4, ENST00000372739.7
    Conserved Domains (5) summary
    cd11808
    Location:9711023
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:23322400
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:679890
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam08726
    Location:24072475
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    pfam00435
    Location:16631765
    Spectrin; Spectrin repeat
  2. NM_001195532.2NP_001182461.1  spectrin alpha chain, non-erythrocytic 1 isoform 3

    See identical proteins and their annotated locations for NP_001182461.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two in-frame exons in the coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AL356481
    Consensus CDS
    CCDS75914.1
    UniProtKB/Swiss-Prot
    Q13813
    UniProtKB/TrEMBL
    A0A384P5S9
    Related
    ENSP00000350882.6, ENST00000358161.9
    Conserved Domains (5) summary
    cd11808
    Location:9711023
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:23072375
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:679890
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:16381742
    Spectrin; Spectrin repeat
    pfam08726
    Location:23822450
    EFhand_Ca_insen; Ca2+ insensitive EF hand
  3. NM_001363759.2NP_001350688.1  spectrin alpha chain, non-erythrocytic 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL356481
    Consensus CDS
    CCDS87695.1
    UniProtKB/TrEMBL
    A0A0D9SGF6
    Related
    ENSP00000487444.1, ENST00000630866.2
    Conserved Domains (5) summary
    cd11808
    Location:9711023
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:23532421
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:679890
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:16631767
    Spectrin; Spectrin repeat
    pfam08726
    Location:24282496
    EFhand_Ca_insen; Ca2+ insensitive EF hand
  4. NM_001363765.2NP_001350694.1  spectrin alpha chain, non-erythrocytic 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL356481
    Consensus CDS
    CCDS87696.1
    UniProtKB/TrEMBL
    A0A0D9SF54
    Related
    ENSP00000486308.1, ENST00000630804.2
    Conserved Domains (5) summary
    cd11808
    Location:9711023
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:23122380
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:679890
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam08726
    Location:23872455
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    pfam00435
    Location:16431745
    Spectrin; Spectrin repeat
  5. NM_001375310.1NP_001362239.1  spectrin alpha chain, non-erythrocytic 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL356481
    Consensus CDS
    CCDS94501.1
    Related
    ENSP00000515764.1, ENST00000704202.1
    Conserved Domains (5) summary
    cd11808
    Location:9711023
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:23612429
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:679890
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam08726
    Location:24362504
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    pfam00435
    Location:16631765
    Spectrin; Spectrin repeat
  6. NM_001375311.2NP_001362240.1  spectrin alpha chain, non-erythrocytic 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL356481
    Consensus CDS
    CCDS48036.1
    Related
    ENSP00000516412.1, ENST00000706487.1
    Conserved Domains (5) summary
    cd11808
    Location:9711023
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:23322400
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:679890
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam08726
    Location:24072475
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    pfam00435
    Location:16631765
    Spectrin; Spectrin repeat
  7. NM_001375312.2NP_001362241.2  spectrin alpha chain, non-erythrocytic 1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AL356481
    Consensus CDS
    CCDS94500.1
    Related
    ENSP00000515765.1, ENST00000704203.1
    Conserved Domains (5) summary
    cd11808
    Location:9831035
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:23442412
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:691902
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam08726
    Location:24192487
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    pfam00435
    Location:16751777
    Spectrin; Spectrin repeat
  8. NM_001375313.1NP_001362242.1  spectrin alpha chain, non-erythrocytic 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL356481
    Conserved Domains (5) summary
    cd11808
    Location:9711023
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:23262394
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:679890
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam08726
    Location:24012469
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    pfam00435
    Location:16631765
    Spectrin; Spectrin repeat
  9. NM_001375314.2NP_001362243.1  spectrin alpha chain, non-erythrocytic 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL356481
    Consensus CDS
    CCDS87696.1
    UniProtKB/TrEMBL
    A0A0D9SF54
    Conserved Domains (5) summary
    cd11808
    Location:9711023
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:23122380
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:679890
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam08726
    Location:23872455
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    pfam00435
    Location:16431745
    Spectrin; Spectrin repeat
  10. NM_001375318.1NP_001362247.1  spectrin alpha chain, non-erythrocytic 1 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AL356481
    Conserved Domains (5) summary
    cd11808
    Location:9831035
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:23652433
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:691902
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam08726
    Location:24402508
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    pfam00435
    Location:16751777
    Spectrin; Spectrin repeat
  11. NM_003127.4NP_003118.2  spectrin alpha chain, non-erythrocytic 1 isoform 2

    See identical proteins and their annotated locations for NP_003118.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The resulting isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AL356481
    Consensus CDS
    CCDS6905.1
    UniProtKB/Swiss-Prot
    Q13813, Q9P0V0
    Related
    ENSP00000361816.4, ENST00000372731.8
    Conserved Domains (6) summary
    cd11808
    Location:9711023
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:23272395
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:679890
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:16581762
    Spectrin; Spectrin repeat
    pfam08726
    Location:24022470
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    pfam13499
    Location:23302395
    EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    128552587..128633662
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047423783.1XP_047279739.1  spectrin alpha chain, non-erythrocytic 1 isoform X1

  2. XM_047423787.1XP_047279743.1  spectrin alpha chain, non-erythrocytic 1 isoform X5

    Related
    ENSP00000486547.2, ENST00000627441.3
  3. XM_047423790.1XP_047279746.1  spectrin alpha chain, non-erythrocytic 1 isoform X8

  4. XM_047423784.1XP_047279740.1  spectrin alpha chain, non-erythrocytic 1 isoform X2

  5. XM_047423789.1XP_047279745.1  spectrin alpha chain, non-erythrocytic 1 isoform X7

  6. XM_047423791.1XP_047279747.1  spectrin alpha chain, non-erythrocytic 1 isoform X9

  7. XM_047423786.1XP_047279742.1  spectrin alpha chain, non-erythrocytic 1 isoform X4

  8. XM_047423794.1XP_047279750.1  spectrin alpha chain, non-erythrocytic 1 isoform X12

  9. XM_017015060.2XP_016870549.1  spectrin alpha chain, non-erythrocytic 1 isoform X15

    Conserved Domains (5) summary
    PTZ00184
    Location:23112460
    PTZ00184; calmodulin; Provisional
    smart00150
    Location:16581758
    SPEC; Spectrin repeats
    cd11808
    Location:9831035
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:23182386
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:691902
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  10. XM_047423788.1XP_047279744.1  spectrin alpha chain, non-erythrocytic 1 isoform X6

  11. XM_047423796.1XP_047279752.1  spectrin alpha chain, non-erythrocytic 1 isoform X14

  12. XM_047423797.1XP_047279753.1  spectrin alpha chain, non-erythrocytic 1 isoform X16

  13. XM_047423785.1XP_047279741.1  spectrin alpha chain, non-erythrocytic 1 isoform X3

  14. XM_047423795.1XP_047279751.1  spectrin alpha chain, non-erythrocytic 1 isoform X13

  15. XM_006717251.3XP_006717314.1  spectrin alpha chain, non-erythrocytic 1 isoform X10

    Related
    ENSP00000515766.1, ENST00000704204.1
    Conserved Domains (6) summary
    cd11808
    Location:9711023
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:23332401
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:679890
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:16431747
    Spectrin; Spectrin repeat
    pfam08726
    Location:24082476
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    pfam13499
    Location:23362401
    EF-hand_7; EF-hand domain pair
  16. XM_047423798.1XP_047279754.1  spectrin alpha chain, non-erythrocytic 1 isoform X17

  17. XM_047423793.1XP_047279749.1  spectrin alpha chain, non-erythrocytic 1 isoform X11

  18. XM_047423799.1XP_047279755.1  spectrin alpha chain, non-erythrocytic 1 isoform X18

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    140759427..140840530
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)