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SPTAN1 spectrin alpha, non-erythrocytic 1 [ Homo sapiens (human) ]

Gene ID: 6709, updated on 24-Nov-2020

Summary

Official Symbol
SPTAN1provided by HGNC
Official Full Name
spectrin alpha, non-erythrocytic 1provided by HGNC
Primary source
HGNC:HGNC:11273
See related
Ensembl:ENSG00000197694 MIM:182810
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DEE5; NEAS; EIEE5; SPTA2
Summary
Spectrins are a family of filamentous cytoskeletal proteins that function as essential scaffold proteins that stabilize the plasma membrane and organize intracellular organelles. Spectrins are composed of alpha and beta dimers that associate to form tetramers linked in a head-to-head arrangement. This gene encodes an alpha spectrin that is specifically expressed in nonerythrocytic cells. The encoded protein has been implicated in other cellular functions including DNA repair and cell cycle regulation. Mutations in this gene are the cause of early infantile epileptic encephalopathy-5. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010]
Expression
Ubiquitous expression in brain (RPKM 87.7), testis (RPKM 42.9) and 24 other tissues See more
Orthologs

Genomic context

See SPTAN1 in Genome Data Viewer
Location:
9q34.11
Exon count:
60
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (128552564..128633662)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (131314837..131395944)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene GLE1 RNA export mediator Neighboring gene uncharacterized LOC101929270 Neighboring gene RNA, U7 small nuclear 171 pseudogene Neighboring gene dynein 2 intermediate chain 2 Neighboring gene uncharacterized LOC105376287 Neighboring gene vesicle transport through interaction with t-SNAREs 1B pseudogene 4 Neighboring gene high mobility group AT-hook 1 pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Early infantile epileptic encephalopathy 5
MedGen: C3150731 OMIM: 613477 GeneReviews: Not available
not available
Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of spectrin, alpha, non-erythrocytic 1 (SPTAN1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify spectrin alpha chain (SPTAN1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify spectrin alpha chain (SPTAN1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify spectrin alpha chain (SPTAN1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify spectrin alpha chain (SPTAN1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Rev rev HIV-1 Rev interacting protein, spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) (SPTAN1), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed
Vpr vpr HIV-1 Vpr upregulates SPTAN1 in HeLa cells within 12 hours of exposure PubMed
retropepsin gag-pol A number of focal adhesion plaque proteins are specifically cleaved by HIV-1 protease, including fimbrin, focal adhesion plaque kinase (FAK), talin, and, to a lesser extent, filamin, spectrin and fibronectin PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ17738, FLJ44613

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin binding IEA
Inferred from Electronic Annotation
more info
 
cadherin binding HDA PubMed 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
MAPK cascade TAS
Traceable Author Statement
more info
 
actin filament capping IEA
Inferred from Electronic Annotation
more info
 
axon guidance TAS
Traceable Author Statement
more info
 
cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum to Golgi vesicle-mediated transport TAS
Traceable Author Statement
more info
 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular vesicle HDA PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
membrane TAS
Traceable Author Statement
more info
PubMed 
microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 
specific granule lumen TAS
Traceable Author Statement
more info
 
spectrin TAS
Traceable Author Statement
more info
PubMed 
tertiary granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
spectrin alpha chain, non-erythrocytic 1
Names
alpha-II spectrin
alpha-fodrin
epididymis secretory sperm binding protein
fodrin alpha chain
spectrin, non-erythroid alpha chain
spectrin, non-erythroid alpha subunit

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027748.1 RefSeqGene

    Range
    5001..86108
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001130438.3NP_001123910.1  spectrin alpha chain, non-erythrocytic 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL356481
    Consensus CDS
    CCDS48036.1
    UniProtKB/Swiss-Prot
    Q13813
    Related
    ENSP00000361824.3, ENST00000372739.6
    Conserved Domains (5) summary
    cd11808
    Location:9711023
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:23322400
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:679890
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam08726
    Location:24072475
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    pfam00435
    Location:16631765
    Spectrin; Spectrin repeat
  2. NM_001195532.2NP_001182461.1  spectrin alpha chain, non-erythrocytic 1 isoform 3

    See identical proteins and their annotated locations for NP_001182461.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two in-frame exons in the coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AL356481
    Consensus CDS
    CCDS75914.1
    UniProtKB/Swiss-Prot
    Q13813
    Related
    ENSP00000350882.6, ENST00000358161.9
    Conserved Domains (5) summary
    cd11808
    Location:9711023
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:23072375
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:679890
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:16381742
    Spectrin; Spectrin repeat
    pfam08726
    Location:23822450
    EFhand_Ca_insen; Ca2+ insensitive EF hand
  3. NM_001363759.2NP_001350688.1  spectrin alpha chain, non-erythrocytic 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL356481
    Consensus CDS
    CCDS87695.1
    Related
    ENSP00000487444.1, ENST00000630866.1
    Conserved Domains (5) summary
    cd11808
    Location:9711023
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:23532421
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:679890
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:16631767
    Spectrin; Spectrin repeat
    pfam08726
    Location:24282496
    EFhand_Ca_insen; Ca2+ insensitive EF hand
  4. NM_001363765.2NP_001350694.1  spectrin alpha chain, non-erythrocytic 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL356481
    Consensus CDS
    CCDS87696.1
    Related
    ENSP00000486308.1, ENST00000630804.2
    Conserved Domains (5) summary
    cd11808
    Location:9711023
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:23122380
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:679890
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam08726
    Location:23872455
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    pfam00435
    Location:16431745
    Spectrin; Spectrin repeat
  5. NM_001375310.1NP_001362239.1  spectrin alpha chain, non-erythrocytic 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL356481
  6. NM_001375311.2NP_001362240.1  spectrin alpha chain, non-erythrocytic 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL356481
    Conserved Domains (5) summary
    cd11808
    Location:9711023
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:23322400
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:679890
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam08726
    Location:24072475
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    pfam00435
    Location:16631765
    Spectrin; Spectrin repeat
  7. NM_001375312.2NP_001362241.2  spectrin alpha chain, non-erythrocytic 1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AL356481
  8. NM_001375313.1NP_001362242.1  spectrin alpha chain, non-erythrocytic 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL356481
    Conserved Domains (5) summary
    cd11808
    Location:9711023
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:23262394
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:679890
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam08726
    Location:24012469
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    pfam00435
    Location:16631765
    Spectrin; Spectrin repeat
  9. NM_001375314.2NP_001362243.1  spectrin alpha chain, non-erythrocytic 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL356481
    Conserved Domains (5) summary
    cd11808
    Location:9711023
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:23122380
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:679890
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam08726
    Location:23872455
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    pfam00435
    Location:16431745
    Spectrin; Spectrin repeat
  10. NM_001375318.1NP_001362247.1  spectrin alpha chain, non-erythrocytic 1 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AL356481
    Conserved Domains (5) summary
    cd11808
    Location:9831035
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:23652433
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:691902
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam08726
    Location:24402508
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    pfam00435
    Location:16751777
    Spectrin; Spectrin repeat
  11. NM_003127.4NP_003118.2  spectrin alpha chain, non-erythrocytic 1 isoform 2

    See identical proteins and their annotated locations for NP_003118.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The resulting isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AL356481
    Consensus CDS
    CCDS6905.1
    UniProtKB/Swiss-Prot
    Q13813
    Related
    ENSP00000361816.4, ENST00000372731.8
    Conserved Domains (6) summary
    cd11808
    Location:9711023
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:23272395
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:679890
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:16581762
    Spectrin; Spectrin repeat
    pfam08726
    Location:24022470
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    pfam13499
    Location:23302395
    EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    128552564..128633662
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006717251.2XP_006717314.1  spectrin alpha chain, non-erythrocytic 1 isoform X8

    Conserved Domains (6) summary
    cd11808
    Location:9711023
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:23332401
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:679890
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:16431747
    Spectrin; Spectrin repeat
    pfam08726
    Location:24082476
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    pfam13499
    Location:23362401
    EF-hand_7; EF-hand domain pair
  2. XM_006717250.1XP_006717313.1  spectrin alpha chain, non-erythrocytic 1 isoform X7

    Conserved Domains (6) summary
    cd11808
    Location:9831035
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:23382406
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:691902
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:16751779
    Spectrin; Spectrin repeat
    pfam08726
    Location:24132481
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    pfam13499
    Location:23412406
    EF-hand_7; EF-hand domain pair
  3. XM_006717246.1XP_006717309.1  spectrin alpha chain, non-erythrocytic 1 isoform X2

    Conserved Domains (6) summary
    cd11808
    Location:9831035
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:23602428
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:691902
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:16701774
    Spectrin; Spectrin repeat
    pfam08726
    Location:24352503
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    pfam13499
    Location:23632428
    EF-hand_7; EF-hand domain pair
  4. XM_006717249.1XP_006717312.1  spectrin alpha chain, non-erythrocytic 1 isoform X6

    Conserved Domains (6) summary
    cd11808
    Location:9831035
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:23392407
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:691902
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:16701774
    Spectrin; Spectrin repeat
    pfam08726
    Location:24142482
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    pfam13499
    Location:23422407
    EF-hand_7; EF-hand domain pair
  5. XM_006717252.3XP_006717315.1  spectrin alpha chain, non-erythrocytic 1 isoform X10

    Conserved Domains (6) summary
    cd11808
    Location:9831035
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:23242392
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:691902
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:16551759
    Spectrin; Spectrin repeat
    pfam08726
    Location:23992467
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    pfam13499
    Location:23272392
    EF-hand_7; EF-hand domain pair
  6. XM_006717253.1XP_006717316.1  spectrin alpha chain, non-erythrocytic 1 isoform X11

    Conserved Domains (6) summary
    cd11808
    Location:9831035
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:23192387
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:691902
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:16501754
    Spectrin; Spectrin repeat
    pfam08726
    Location:23942462
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    pfam13499
    Location:23222387
    EF-hand_7; EF-hand domain pair
  7. XM_006717247.2XP_006717310.1  spectrin alpha chain, non-erythrocytic 1 isoform X4

    Conserved Domains (6) summary
    cd11808
    Location:9831035
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:23452413
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:691902
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:16551759
    Spectrin; Spectrin repeat
    pfam08726
    Location:24202488
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    pfam13499
    Location:23482413
    EF-hand_7; EF-hand domain pair
  8. XM_017015060.1XP_016870549.1  spectrin alpha chain, non-erythrocytic 1 isoform X12

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