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Anp32e acidic (leucine-rich) nuclear phosphoprotein 32 family, member E [ Mus musculus (house mouse) ]

Gene ID: 66471, updated on 30-Oct-2022

Summary

Official Symbol
Anp32eprovided by MGI
Official Full Name
acidic (leucine-rich) nuclear phosphoprotein 32 family, member Eprovided by MGI
Primary source
MGI:MGI:1913721
See related
Ensembl:ENSMUSG00000015749 AllianceGenome:MGI:1913721
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CPD1; LANPL; LANP-L; mLANP-L; 2810018A15Rik
Summary
Enables phosphatase inhibitor activity. Predicted to be involved in histone exchange and regulation of apoptotic process. Predicted to act upstream of or within chromatin organization. Located in cytoplasmic vesicle and nucleus. Is expressed in brain; liver; retina layer; and skeletal muscle. Orthologous to human ANP32E (acidic nuclear phosphoprotein 32 family member E). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E11.5 (RPKM 136.9), liver E14 (RPKM 55.6) and 14 other tissues See more
Orthologs
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Genomic context

See Anp32e in Genome Data Viewer
Location:
3; 3 F2.1
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (95836557..95854699)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (95929245..95947387)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene aph1 homolog A, gamma secretase subunit Neighboring gene carbonic anhydrase 14 Neighboring gene predicted gene, 46815 Neighboring gene ferritin light chain 2 pseudogene Neighboring gene predicted gene 9054

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC11640

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables histone binding ISO
Inferred from Sequence Orthology
more info
 
enables histone chaperone activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphatase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphatase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein folding chaperone ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of Swr1 complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
acidic leucine-rich nuclear phosphoprotein 32 family member E
Names
LANP-like protein
cerebellar postnatal development protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001253757.1NP_001240686.1  acidic leucine-rich nuclear phosphoprotein 32 family member E isoform 2

    See identical proteins and their annotated locations for NP_001240686.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC092855, AI613710, AK147888, AK159446, BY270013, CF952181
    Consensus CDS
    CCDS57238.1
    UniProtKB/Swiss-Prot
    P97822
    UniProtKB/TrEMBL
    Q3TX26
    Related
    ENSMUSP00000015893.7, ENSMUST00000015893.13
    Conserved Domains (4) summary
    cd00116
    Location:16146
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:4465
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:88130
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:65125
    LRR_8; Leucine rich repeat
  2. NM_001253758.1NP_001240687.1  acidic leucine-rich nuclear phosphoprotein 32 family member E isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC092855, AI613710
    Consensus CDS
    CCDS57239.1
    UniProtKB/TrEMBL
    E9Q5H9
    Related
    ENSMUSP00000130599.2, ENSMUST00000171368.8
  3. NM_023210.4NP_075699.3  acidic leucine-rich nuclear phosphoprotein 32 family member E isoform 1

    See identical proteins and their annotated locations for NP_075699.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AI613710, AK049647, AK159446, BY254191
    Consensus CDS
    CCDS17626.1
    UniProtKB/Swiss-Prot
    P97822, Q9CZD2
    UniProtKB/TrEMBL
    Q3TX26
    Related
    ENSMUSP00000128483.2, ENSMUST00000165307.8
    Conserved Domains (4) summary
    cd00116
    Location:16146
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:4465
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:88130
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:65125
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    95836557..95854699
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011240193.2XP_011238495.1  acidic leucine-rich nuclear phosphoprotein 32 family member E isoform X1

    Conserved Domains (2) summary
    sd00033
    Location:4465
    LRR_RI; leucine-rich repeat [structural motif]
    pfam14580
    Location:34113
    LRR_9; Leucine-rich repeat