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ANP32E acidic nuclear phosphoprotein 32 family member E [ Homo sapiens (human) ]

Gene ID: 81611, updated on 24-Nov-2020

Summary

Official Symbol
ANP32Eprovided by HGNC
Official Full Name
acidic nuclear phosphoprotein 32 family member Eprovided by HGNC
Primary source
HGNC:HGNC:16673
See related
Ensembl:ENSG00000143401 MIM:609611
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LANPL; LANP-L
Expression
Ubiquitous expression in lymph node (RPKM 31.5), bone marrow (RPKM 21.4) and 24 other tissues See more
Orthologs

Genomic context

See ANP32E in Genome Data Viewer
Location:
1q21.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (150218417..150236133, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (150190717..150208504, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr1.8432 Neighboring gene RNA, 7SL, cytoplasmic 480, pseudogene Neighboring gene RNA, U2 small nuclear 17, pseudogene Neighboring gene carbonic anhydrase 14 Neighboring gene small nucleolar RNA, C/D box 13C

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Biological insights from 108 schizophrenia-associated genetic loci.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, acidic leucine-rich nuclear phosphoprotein 32 E (ANP32E), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with ANP32E is decreased by RRE PubMed
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human acidic (leucine-rich) nuclear phosphoprotein 32 family, member E (ANP32E) at amino acid residues 235-236 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC5350

Gene Ontology Provided by GOA

Function Evidence Code Pubs
histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone binding IDA
Inferred from Direct Assay
more info
PubMed 
phosphatase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatase inhibitor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
histone exchange IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone exchange IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Swr1 complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
acidic leucine-rich nuclear phosphoprotein 32 family member E
Names
LANP-like protein
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
leucine-rich acidic nuclear protein like

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136478.4NP_001129950.1  acidic leucine-rich nuclear phosphoprotein 32 family member E isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC242988
    Consensus CDS
    CCDS44214.1
    UniProtKB/Swiss-Prot
    Q9BTT0
    Related
    ENSP00000393718.2, ENST00000436748.6
  2. NM_001136479.3NP_001129951.1  acidic leucine-rich nuclear phosphoprotein 32 family member E isoform 3

    See identical proteins and their annotated locations for NP_001129951.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and initiates translation at a downstream start codon compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC242988
    Consensus CDS
    CCDS44215.1
    UniProtKB/Swiss-Prot
    Q9BTT0
    Related
    ENSP00000481415.1, ENST00000616917.4
    Conserved Domains (2) summary
    sd00033
    Location:1841
    LRR_RI; leucine-rich repeat [structural motif]
    pfam14580
    Location:198
    LRR_9; Leucine-rich repeat
  3. NM_001280559.2NP_001267488.1  acidic leucine-rich nuclear phosphoprotein 32 family member E isoform 4

    See identical proteins and their annotated locations for NP_001267488.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has an alternate splice site in the 3' coding region compared to variant 1. The resulting isoform (4) lacks an internal aa compared to isoform 1.
    Source sequence(s)
    AC242988
    UniProtKB/Swiss-Prot
    Q9BTT0
    Conserved Domains (3) summary
    cd09293
    Location:53126
    AMN1; Antagonist of mitotic exit network protein 1
    sd00033
    Location:4465
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:65125
    LRR_8; Leucine rich repeat
  4. NM_001280560.2NP_001267489.1  acidic leucine-rich nuclear phosphoprotein 32 family member E isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks two internal exons compared to variant 1. The resulting isoform (5) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC242988
    Consensus CDS
    CCDS60245.1
    UniProtKB/Swiss-Prot
    Q9BTT0
    UniProtKB/TrEMBL
    B4E0D5, E9PLC4
    Related
    ENSP00000435215.1, ENST00000533654.5
    Conserved Domains (2) summary
    sd00033
    Location:4465
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:65107
    LRR_4; Leucine Rich repeats (2 copies)
  5. NM_030920.5NP_112182.1  acidic leucine-rich nuclear phosphoprotein 32 family member E isoform 1

    See identical proteins and their annotated locations for NP_112182.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC242988
    Consensus CDS
    CCDS946.1
    UniProtKB/Swiss-Prot
    Q9BTT0
    Related
    ENSP00000463154.1, ENST00000583931.6
    Conserved Domains (2) summary
    sd00033
    Location:4465
    LRR_RI; leucine-rich repeat [structural motif]
    pfam14580
    Location:34146
    LRR_9; Leucine-rich repeat

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    150218417..150236133 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005245514.4XP_005245571.1  acidic leucine-rich nuclear phosphoprotein 32 family member E isoform X3

    See identical proteins and their annotated locations for XP_005245571.1

    Conserved Domains (4) summary
    cd00116
    Location:15146
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:4465
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:88130
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:65125
    LRR_8; Leucine rich repeat
  2. XM_017002418.2XP_016857907.1  acidic leucine-rich nuclear phosphoprotein 32 family member E isoform X2

  3. XM_005245513.4XP_005245570.1  acidic leucine-rich nuclear phosphoprotein 32 family member E isoform X1

    Conserved Domains (3) summary
    cd09293
    Location:53126
    AMN1; Antagonist of mitotic exit network protein 1
    sd00033
    Location:4465
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:65125
    LRR_8; Leucine rich repeat
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