ANP32E acidic nuclear phosphoprotein 32 family member E [Homo sapiens (human)] - Gene

Summary

Official Symbol: ANP32Eprovided by HGNC
Official Full Name: acidic nuclear phosphoprotein 32 family member Eprovided by HGNC
Primary source: HGNC:HGNC:16673
See related: Ensembl:ENSG00000143401 MIM:609611; AllianceGenome:HGNC:16673
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LANPL; LANP-L
Summary: Enables histone binding activity. Involved in histone exchange. Located in nucleus. Part of Swr1 complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in lymph node (RPKM 31.5), bone marrow (RPKM 21.4) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1q21.2

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2023_03	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (150218417..150236112, complement)
RS_2023_03	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (149343213..149361083, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (150190717..150208460, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ANP32E contributes to gastric cancer progression via NUF2 upregulation.
Title: ANP32E contributes to gastric cancer progression via NUF2 upregulation.
Subtype-Independent ANP32E Reduction During Breast Cancer Progression in Accordance with Chromatin Relaxation.
Title: Subtype-Independent ANP32E Reduction During Breast Cancer Progression in Accordance with Chromatin Relaxation.
Hsa-let-7c exerts an anti-tumor function by negatively regulating ANP32E in lung adenocarcinoma.
Title: Hsa-let-7c exerts an anti-tumor function by negatively regulating ANP32E in lung adenocarcinoma.
Over-expression of ANP32E is associated with poor prognosis of pancreatic cancer and promotes cell proliferation and migration through regulating beta-catenin.
Title: Over-expression of ANP32E is associated with poor prognosis of pancreatic cancer and promotes cell proliferation and migration through regulating β-catenin.
Findings suggest that ANP32E promotes THCA cell proliferation and migration via potentiating AKT/mTOR/HK2-mediated glycolysis.
Title: Up-regulated ANP32E promotes the thyroid carcinoma cell proliferation and migration via activating AKT/mTOR/HK2-mediated glycolysis.
A systems biology approach allowed us to identify a comprehensive mechanism of action of steroid-refractoriness, highlighting the key role of steroid-induced transcription and the potential implication of ANP32E in this phenomenon.
Title: ANP32E, a Protein Involved in Steroid-Refractoriness in Ulcerative Colitis, Identified by a Systems Biology Approach.
ANP32E is an efficient prognostic marker, and it promotes the G1/S transition and induces tumorigenesis of Triple-negative breast cancer cells by transcriptionally inducing E2F1.
Title: ANP32E induces tumorigenesis of triple-negative breast cancer cells by upregulating E2F1.
Study identified ANP32E as one of the miR-141 targets, and demonstrated its involvement in the regulation of cell proliferation, migration, and invasion of breast cancer cells.
Title: Downregulation of miRNA-141 in breast cancer cells is associated with cell migration and invasion: involvement of ANP32E targeting.
Dynamic modulation of H2A.Z exchange and removal by Anp32e reveals the importance of the nucleosome surface and nucleosome dynamics in processing the damaged chromatin template during DSB repair.
Title: Histone chaperone Anp32e removes H2A.Z from DNA double-strand breaks and promotes nucleosome reorganization and DNA repair.
Anp32e may help to resolve the non-nucleosomal H2A.Z aggregates and also facilitate the removal of H2A.Z at the +1 nucleosomes, and the latter may help RNA polymerase II to pass the first nucleosomal barrier.
Title: Anp32e, a higher eukaryotic histone chaperone directs preferential recognition for H2A.Z.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Rev	rev	HIV-1 Rev interacting protein, acidic leucine-rich nuclear phosphoprotein 32 E (ANP32E), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with ANP32E is decreased by RRE	PubMed
retropepsin	gag-pol	Positional proteomics analysis identifies the cleavage of human acidic (leucine-rich) nuclear phosphoprotein 32 family, member E (ANP32E) at amino acid residues 235-236 by the HIV-1 protease	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AL009464 (e-PCR)
- UniSTS:65904

RH102078 (e-PCR)
- UniSTS:96412

RH93887 (e-PCR)
- UniSTS:90051

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables histone binding	IDA Inferred from Direct Assay more info	PubMed
enables histone chaperone activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables phosphatase inhibitor activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein folding chaperone	EXP Inferred from Experiment more info	PubMed

Process	Evidence Code	Pubs
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in protein folding	IEA Inferred from Electronic Annotation more info
involved_in regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Component	Evidence Code	Pubs
part_of Swr1 complex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: acidic leucine-rich nuclear phosphoprotein 32 family member E

Names: LANP-like protein; acidic (leucine-rich) nuclear phosphoprotein 32 family, member E; leucine-rich acidic nuclear protein like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001136478.4 → NP_001129950.1 acidic leucine-rich nuclear phosphoprotein 32 family member E isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AC242988

Consensus CDS

CCDS44214.1

UniProtKB/Swiss-Prot

Q9BTT0

Related

ENSP00000393718.2, ENST00000436748.6
NM_001136479.3 → NP_001129951.1 acidic leucine-rich nuclear phosphoprotein 32 family member E isoform 3

See identical proteins and their annotated locations for NP_001129951.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and initiates translation at a downstream start codon compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AC242988

Consensus CDS

CCDS44215.1

UniProtKB/Swiss-Prot

Q9BTT0

Related

ENSP00000481415.1, ENST00000616917.4

Conserved Domains (2) summary

sd00033
Location:18 → 41

LRR_RI; leucine-rich repeat [structural motif]

pfam14580
Location:5 → 98

LRR_9; Leucine-rich repeat
NM_001280559.2 → NP_001267488.1 acidic leucine-rich nuclear phosphoprotein 32 family member E isoform 4

See identical proteins and their annotated locations for NP_001267488.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) has an alternate splice site in the 3' coding region compared to variant 1. The resulting isoform (4) lacks an internal aa compared to isoform 1.

Source sequence(s)

AC242988

UniProtKB/Swiss-Prot

Q9BTT0

Conserved Domains (2) summary

sd00033
Location:44 → 65

LRR_RI; leucine-rich repeat [structural motif]

pfam14580
Location:34 → 146

LRR_9; Leucine-rich repeat
NM_001280560.2 → NP_001267489.1 acidic leucine-rich nuclear phosphoprotein 32 family member E isoform 5

Status: VALIDATED

Description

Transcript Variant: This variant (5) lacks two internal exons compared to variant 1. The resulting isoform (5) is shorter and has a distinct C-terminus compared to isoform 1.

Source sequence(s)

AC242988

Consensus CDS

CCDS60245.1

UniProtKB/Swiss-Prot

Q9BTT0

UniProtKB/TrEMBL

B4E0D5, E9PLC4

Related

ENSP00000435215.1, ENST00000533654.5

Conserved Domains (2) summary

sd00033
Location:44 → 65

LRR_RI; leucine-rich repeat [structural motif]

pfam12799
Location:65 → 107

LRR_4; Leucine Rich repeats (2 copies)
NM_030920.5 → NP_112182.1 acidic leucine-rich nuclear phosphoprotein 32 family member E isoform 1

See identical proteins and their annotated locations for NP_112182.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC242988

Consensus CDS

CCDS946.1

UniProtKB/Swiss-Prot

Q8WWW9, Q9BTT0

Related

ENSP00000463154.1, ENST00000583931.6

Conserved Domains (2) summary

sd00033
Location:44 → 65

LRR_RI; leucine-rich repeat [structural motif]

pfam14580
Location:34 → 146

LRR_9; Leucine-rich repeat

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

150218417..150236112 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005245514.5 → XP_005245571.1 acidic leucine-rich nuclear phosphoprotein 32 family member E isoform X3

See identical proteins and their annotated locations for XP_005245571.1

Conserved Domains (4) summary

cd00116
Location:15 → 146

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:44 → 65

LRR_RI; leucine-rich repeat [structural motif]

pfam12799
Location:88 → 130

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:65 → 125

LRR_8; Leucine rich repeat
XM_017002418.3 → XP_016857907.1 acidic leucine-rich nuclear phosphoprotein 32 family member E isoform X2
XM_005245513.5 → XP_005245570.1 acidic leucine-rich nuclear phosphoprotein 32 family member E isoform X1

Conserved Domains (3) summary

cd09293
Location:53 → 126

AMN1; Antagonist of mitotic exit network protein 1

sd00033
Location:44 → 65

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:65 → 125

LRR_8; Leucine rich repeat

Alternate T2T-CHM13v2.0

Genomic

NC_060925.1 Alternate T2T-CHM13v2.0

Range

149343213..149361083 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054338923.1 → XP_054194898.1 acidic leucine-rich nuclear phosphoprotein 32 family member E isoform X3
XM_054338921.1 → XP_054194896.1 acidic leucine-rich nuclear phosphoprotein 32 family member E isoform X1
XM_054338922.1 → XP_054194897.1 acidic leucine-rich nuclear phosphoprotein 32 family member E isoform X2