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SNAP25 synaptosome associated protein 25 [ Homo sapiens (human) ]

Gene ID: 6616, updated on 24-Dec-2019

Summary

Official Symbol
SNAP25provided by HGNC
Official Full Name
synaptosome associated protein 25provided by HGNC
Primary source
HGNC:HGNC:11132
See related
Ensembl:ENSG00000132639 MIM:600322
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SUP; RIC4; SEC9; SNAP; CMS18; RIC-4; SNAP-25; bA416N4.2; dJ1068F16.2
Summary
Synaptic vesicle membrane docking and fusion is mediated by SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) located on the vesicle membrane (v-SNAREs) and the target membrane (t-SNAREs). The assembled v-SNARE/t-SNARE complex consists of a bundle of four helices, one of which is supplied by v-SNARE and the other three by t-SNARE. For t-SNAREs on the plasma membrane, the protein syntaxin supplies one helix and the protein encoded by this gene contributes the other two. Therefore, this gene product is a presynaptic plasma membrane protein involved in the regulation of neurotransmitter release. Two alternative transcript variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward brain (RPKM 418.5) See more
Orthologs

Genomic context

See SNAP25 in Genome Data Viewer
Location:
20p12.2
Exon count:
17
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (10218830..10307420)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (10199477..10288068)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene SNAP25 antisense RNA 1 Neighboring gene ankyrin repeat and EF-hand domain containing 1 Neighboring gene uncharacterized LOC105372524 Neighboring gene uncharacterized LOC112268268 Neighboring gene HIG1 hypoxia inducible domain family member 1A pseudogene 15

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Myasthenic syndrome, congenital, 18 Compare labs

NHGRI GWAS Catalog

Description
Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
NHGRI GWA Catalog
Hypertrophy-associated polymorphisms ascertained in a founder cohort applied to heart failure risk and mortality.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat downregulates the pre-synaptic protein SNAP25 expression via neuronal mir-128 in primary cortical neurons PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23079

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium-dependent protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
syntaxin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
syntaxin-1 binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
syntaxin-1 binding IPI
Inferred from Physical Interaction
more info
PubMed 
voltage-gated potassium channel activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
associative learning IEA
Inferred from Electronic Annotation
more info
 
chemical synaptic transmission NAS
Non-traceable Author Statement
more info
PubMed 
exocytic insertion of neurotransmitter receptor to postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glutamate secretion TAS
Traceable Author Statement
more info
 
locomotory behavior IEA
Inferred from Electronic Annotation
more info
 
long-term synaptic potentiation IEA
Inferred from Electronic Annotation
more info
 
neurotransmitter receptor internalization IEA
Inferred from Electronic Annotation
more info
 
neurotransmitter secretion TAS
Traceable Author Statement
more info
 
neurotransmitter uptake NAS
Non-traceable Author Statement
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
regulation of insulin secretion TAS
Traceable Author Statement
more info
PubMed 
regulation of neuron projection development IEA
Inferred from Electronic Annotation
more info
 
synaptic vesicle docking NAS
Non-traceable Author Statement
more info
PubMed 
synaptic vesicle exocytosis TAS
Traceable Author Statement
more info
PubMed 
synaptic vesicle fusion to presynaptic active zone membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
synaptic vesicle priming IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with BLOC-1 complex IDA
Inferred from Direct Assay
more info
PubMed 
SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SNARE complex IDA
Inferred from Direct Assay
more info
PubMed 
SNARE complex ISS
Inferred from Sequence or Structural Similarity
more info
 
SNARE complex TAS
Traceable Author Statement
more info
PubMed 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extrinsic component of cytoplasmic side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
growth cone ISS
Inferred from Sequence or Structural Similarity
more info
 
membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron projection ISS
Inferred from Sequence or Structural Similarity
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
postsynapse IEA
Inferred from Electronic Annotation
more info
 
presynaptic membrane TAS
Traceable Author Statement
more info
PubMed 
somatodendritic compartment IEA
Inferred from Electronic Annotation
more info
 
specific granule membrane TAS
Traceable Author Statement
more info
 
synaptic vesicle IEA
Inferred from Electronic Annotation
more info
 
synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tertiary granule membrane TAS
Traceable Author Statement
more info
 
trans-Golgi network IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with vesicle IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with voltage-gated potassium channel complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
synaptosomal-associated protein 25
Names
resistance to inhibitors of cholinesterase 4 homolog
synaptosomal-associated protein, 25kDa
synaptosome associated protein 25kDa

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029626.1 RefSeqGene

    Range
    4970..93592
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001322902.2NP_001309831.1  synaptosomal-associated protein 25 isoform SNAP25A

    Status: REVIEWED

    Source sequence(s)
    AL023913, AL354824
    Consensus CDS
    CCDS13109.1
    UniProtKB/Swiss-Prot
    P60880
    Conserved Domains (3) summary
    cd15885
    Location:143201
    SNARE_SNAP25C; C-terminal SNARE motif of SNAP25
    cd15894
    Location:1082
    SNARE_SNAP25N; N-terminal SNARE motif of SNAP25
    pfam00835
    Location:91141
    SNAP-25; SNAP-25 family
  2. NM_001322903.2NP_001309832.1  synaptosomal-associated protein 25 isoform SNAP25B

    Status: REVIEWED

    Source sequence(s)
    AL023913, AL354824
    Consensus CDS
    CCDS13110.1
    UniProtKB/Swiss-Prot
    P60880
    Conserved Domains (3) summary
    cd15885
    Location:143201
    SNARE_SNAP25C; C-terminal SNARE motif of SNAP25
    cd15894
    Location:1082
    SNARE_SNAP25N; N-terminal SNARE motif of SNAP25
    pfam00835
    Location:91141
    SNAP-25; SNAP-25 family
  3. NM_001322904.2NP_001309833.1  synaptosomal-associated protein 25 isoform SNAP25B

    Status: REVIEWED

    Source sequence(s)
    AL023913, AL354824
    Consensus CDS
    CCDS13110.1
    UniProtKB/Swiss-Prot
    P60880
    Conserved Domains (3) summary
    cd15885
    Location:143201
    SNARE_SNAP25C; C-terminal SNARE motif of SNAP25
    cd15894
    Location:1082
    SNARE_SNAP25N; N-terminal SNARE motif of SNAP25
    pfam00835
    Location:91141
    SNAP-25; SNAP-25 family
  4. NM_001322905.2NP_001309834.1  synaptosomal-associated protein 25 isoform SNAP25B

    Status: REVIEWED

    Source sequence(s)
    AL023913, AL354824
    Consensus CDS
    CCDS13110.1
    UniProtKB/Swiss-Prot
    P60880
    Conserved Domains (3) summary
    cd15885
    Location:143201
    SNARE_SNAP25C; C-terminal SNARE motif of SNAP25
    cd15894
    Location:1082
    SNARE_SNAP25N; N-terminal SNARE motif of SNAP25
    pfam00835
    Location:91141
    SNAP-25; SNAP-25 family
  5. NM_001322906.2NP_001309835.1  synaptosomal-associated protein 25 isoform SNAP25B

    Status: REVIEWED

    Source sequence(s)
    AL023913, AL354824
    Consensus CDS
    CCDS13110.1
    UniProtKB/Swiss-Prot
    P60880
    Conserved Domains (3) summary
    cd15885
    Location:143201
    SNARE_SNAP25C; C-terminal SNARE motif of SNAP25
    cd15894
    Location:1082
    SNARE_SNAP25N; N-terminal SNARE motif of SNAP25
    pfam00835
    Location:91141
    SNAP-25; SNAP-25 family
  6. NM_001322907.2NP_001309836.1  synaptosomal-associated protein 25 isoform SNAP25B

    Status: REVIEWED

    Source sequence(s)
    AL023913, AL354824
    Consensus CDS
    CCDS13110.1
    UniProtKB/Swiss-Prot
    P60880
    Conserved Domains (3) summary
    cd15885
    Location:143201
    SNARE_SNAP25C; C-terminal SNARE motif of SNAP25
    cd15894
    Location:1082
    SNARE_SNAP25N; N-terminal SNARE motif of SNAP25
    pfam00835
    Location:91141
    SNAP-25; SNAP-25 family
  7. NM_001322908.2NP_001309837.1  synaptosomal-associated protein 25 isoform SNAP25B

    Status: REVIEWED

    Source sequence(s)
    AL023913, AL354824
    Consensus CDS
    CCDS13110.1
    UniProtKB/Swiss-Prot
    P60880
    Conserved Domains (3) summary
    cd15885
    Location:143201
    SNARE_SNAP25C; C-terminal SNARE motif of SNAP25
    cd15894
    Location:1082
    SNARE_SNAP25N; N-terminal SNARE motif of SNAP25
    pfam00835
    Location:91141
    SNAP-25; SNAP-25 family
  8. NM_001322909.2NP_001309838.1  synaptosomal-associated protein 25 isoform SNAP25B

    Status: REVIEWED

    Source sequence(s)
    AL023913, AL354824
    Consensus CDS
    CCDS13110.1
    UniProtKB/Swiss-Prot
    P60880
    Conserved Domains (3) summary
    cd15885
    Location:143201
    SNARE_SNAP25C; C-terminal SNARE motif of SNAP25
    cd15894
    Location:1082
    SNARE_SNAP25N; N-terminal SNARE motif of SNAP25
    pfam00835
    Location:91141
    SNAP-25; SNAP-25 family
  9. NM_001322910.2NP_001309839.1  synaptosomal-associated protein 25 isoform SNAP25B

    Status: REVIEWED

    Source sequence(s)
    AL023913, AL354824
    Consensus CDS
    CCDS13110.1
    UniProtKB/Swiss-Prot
    P60880
    Conserved Domains (3) summary
    cd15885
    Location:143201
    SNARE_SNAP25C; C-terminal SNARE motif of SNAP25
    cd15894
    Location:1082
    SNARE_SNAP25N; N-terminal SNARE motif of SNAP25
    pfam00835
    Location:91141
    SNAP-25; SNAP-25 family
  10. NM_003081.5NP_003072.2  synaptosomal-associated protein 25 isoform SNAP25A

    See identical proteins and their annotated locations for NP_003072.2

    Status: REVIEWED

    Source sequence(s)
    AL023913, AL354824
    Consensus CDS
    CCDS13109.1
    UniProtKB/Swiss-Prot
    P60880
    Related
    ENSP00000307341.2, ENST00000304886.6
    Conserved Domains (3) summary
    cd15885
    Location:143201
    SNARE_SNAP25C; C-terminal SNARE motif of SNAP25
    cd15894
    Location:1082
    SNARE_SNAP25N; N-terminal SNARE motif of SNAP25
    pfam00835
    Location:91141
    SNAP-25; SNAP-25 family
  11. NM_130811.4NP_570824.1  synaptosomal-associated protein 25 isoform SNAP25B

    See identical proteins and their annotated locations for NP_570824.1

    Status: REVIEWED

    Source sequence(s)
    AL023913, AL354824
    Consensus CDS
    CCDS13110.1
    UniProtKB/Swiss-Prot
    P60880
    Related
    ENSP00000254976.2, ENST00000254976.6
    Conserved Domains (3) summary
    cd15885
    Location:143201
    SNARE_SNAP25C; C-terminal SNARE motif of SNAP25
    cd15894
    Location:1082
    SNARE_SNAP25N; N-terminal SNARE motif of SNAP25
    pfam00835
    Location:91141
    SNAP-25; SNAP-25 family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    10218830..10307420
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017028022.1XP_016883511.1  synaptosomal-associated protein 25 isoform X2

    UniProtKB/Swiss-Prot
    P60880
    Conserved Domains (3) summary
    cd15885
    Location:143201
    SNARE_SNAP25C; C-terminal SNARE motif of SNAP25
    cd15894
    Location:1082
    SNARE_SNAP25N; N-terminal SNARE motif of SNAP25
    pfam00835
    Location:91141
    SNAP-25; SNAP-25 family
  2. XM_017028021.2XP_016883510.1  synaptosomal-associated protein 25 isoform X2

    UniProtKB/Swiss-Prot
    P60880
    Conserved Domains (3) summary
    cd15885
    Location:143201
    SNARE_SNAP25C; C-terminal SNARE motif of SNAP25
    cd15894
    Location:1082
    SNARE_SNAP25N; N-terminal SNARE motif of SNAP25
    pfam00835
    Location:91141
    SNAP-25; SNAP-25 family
  3. XM_005260808.5XP_005260865.1  synaptosomal-associated protein 25 isoform X1

    See identical proteins and their annotated locations for XP_005260865.1

    UniProtKB/Swiss-Prot
    P60880
    Conserved Domains (3) summary
    cd15885
    Location:143201
    SNARE_SNAP25C; C-terminal SNARE motif of SNAP25
    cd15894
    Location:1082
    SNARE_SNAP25N; N-terminal SNARE motif of SNAP25
    pfam00835
    Location:91141
    SNAP-25; SNAP-25 family
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