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SNAP25 synaptosome associated protein 25 [ Homo sapiens (human) ]

Gene ID: 6616, updated on 23-Nov-2023

Summary

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Official Symbol
SNAP25provided by HGNC
Official Full Name
synaptosome associated protein 25provided by HGNC
Primary source
HGNC:HGNC:11132
See related
Ensembl:ENSG00000132639 MIM:600322; AllianceGenome:HGNC:11132
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SUP; RIC4; SEC9; SNAP; CMS18; RIC-4; SNAP-25; bA416N4.2; dJ1068F16.2
Summary
Synaptic vesicle membrane docking and fusion is mediated by SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) located on the vesicle membrane (v-SNAREs) and the target membrane (t-SNAREs). The assembled v-SNARE/t-SNARE complex consists of a bundle of four helices, one of which is supplied by v-SNARE and the other three by t-SNARE. For t-SNAREs on the plasma membrane, the protein syntaxin supplies one helix and the protein encoded by this gene contributes the other two. Therefore, this gene product is a presynaptic plasma membrane protein involved in the regulation of neurotransmitter release. Two alternative transcript variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward brain (RPKM 418.5) See more
Orthologs
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Genomic context

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See SNAP25 in Genome Data Viewer
Location:
20p12.2
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (10218830..10307418)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (10261695..10350292)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (10199478..10288066)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene SNAP25 antisense RNA 1 Neighboring gene uncharacterized LOC105372524 Neighboring gene uncharacterized LOC124904959 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr20:10221152-10221653 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr20:10221654-10222154 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr20:10281144-10282061 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:10322076-10322299 Neighboring gene HIG1 hypoxia inducible domain family member 1A pseudogene 15 Neighboring gene ribosomal protein L23a pseudogene 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Role of SNAP-25 MnlI variant in impaired working memory and brain functions in attention deficit/hyperactivity disorder. Fang D, et al. Brain Behav, 2022 Oct. PMID 36068994, Free PMC Article
  2. Cerebrospinal Fluid Synaptosomal-Associated Protein 25 Levels in Patients with Alzheimer's Disease: A Meta-Analysis. Liu Q, et al. J Alzheimers Dis, 2022. PMID 35848017
  3. Upregulation of SNAP25 by HDAC inhibition ameliorates Niemann-Pick Type C disease phenotypes via autophagy induction. Jung Y, et al. Clin Transl Med, 2022 Apr. PMID 35384385, Free PMC Article
  4. Cognitively normal APOE ε4 carriers have specific elevation of CSF SNAP-25. Butt OH, et al. Neurobiol Aging, 2021 Jun. PMID 33765432, Free PMC Article
  5. De novo variants in SNAP25 cause an early-onset developmental and epileptic encephalopathy. Klöckner C, et al. Genet Med, 2021 Apr. PMID 33299146

See all (256) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Role of SNAP-25 in Autism Spectrum Disorders Onset Patterns.
    Title: The Role of SNAP-25 in Autism Spectrum Disorders Onset Patterns.
  2. Sex-specific effects of SNAP-25 genotype on verbal memory and Alzheimer's disease biomarkers in clinically normal older adults.
    Title: Sex-specific effects of SNAP-25 genotype on verbal memory and Alzheimer's disease biomarkers in clinically normal older adults.
  3. Impaired ATF3 signaling involves SNAP25 in SOD1 mutant ALS patients.
    Title: Impaired ATF3 signaling involves SNAP25 in SOD1 mutant ALS patients.
  4. Role of SNAP25 on the occurrence and development of eosinophilic gastritis.
    Title: Role of SNAP25 on the occurrence and development of eosinophilic gastritis.
  5. Non-coding variants in VAMP2 and SNAP25 affect gene expression: potential implications in migraine susceptibility.
    Title: Non-coding variants in VAMP2 and SNAP25 affect gene expression: potential implications in migraine susceptibility.
  6. miR-23a-3p and miR-181a-5p modulate SNAP-25 expression.
    Title: miR-23a-3p and miR-181a-5p modulate SNAP-25 expression.
  7. Investigation of possible associations of the BDNF, SNAP-25 and SYN III genes with the neurocognitive measures: BDNF and SNAP-25 genes might be involved in attention domain, SYN III gene in executive function.
    Title: Investigation of possible associations of the BDNF, SNAP-25 and SYN III genes with the neurocognitive measures: BDNF and SNAP-25 genes might be involved in attention domain, SYN III gene in executive function.
  8. Role of SNAP-25 MnlI variant in impaired working memory and brain functions in attention deficit/hyperactivity disorder.
    Title: Role of SNAP-25 MnlI variant in impaired working memory and brain functions in attention deficit/hyperactivity disorder.
  9. Cerebrospinal Fluid Synaptosomal-Associated Protein 25 Levels in Patients with Alzheimer's Disease: A Meta-Analysis.
    Title: Cerebrospinal Fluid Synaptosomal-Associated Protein 25 Levels in Patients with Alzheimer's Disease: A Meta-Analysis.
  10. Increased levels of the synaptic proteins PSD-95, SNAP-25, and neurogranin in the cerebrospinal fluid of patients with Alzheimer's disease.
    Title: Increased levels of the synaptic proteins PSD-95, SNAP-25, and neurogranin in the cerebrospinal fluid of patients with Alzheimer's disease.
Submit: New GeneRIF Correction See all GeneRIFs (150)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Congenital myasthenic syndrome 18
MedGen: C4225364 OMIM: 616330 GeneReviews: Congenital Myasthenic Syndromes Overview
Compare labs

EBI GWAS Catalog

Description
Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
EBI GWAS Catalog
Hypertrophy-associated polymorphisms ascertained in a founder cohort applied to heart failure risk and mortality.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat downregulates the pre-synaptic protein SNAP25 expression via neuronal mir-128 in primary cortical neurons PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ23079

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-dependent protein binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables lipid binding EXP
Inferred from Experiment
more info
 PubMed 
enables myosin binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding IEA
Inferred from Electronic Annotation
more info
  
enables syntaxin-1 binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables syntaxin-1 binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmembrane transporter binding IEA
Inferred from Electronic Annotation
more info
  
enables voltage-gated potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in SNARE complex assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in associative learning IEA
Inferred from Electronic Annotation
more info
  
involved_in axonogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in chemical synaptic transmission NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in endosomal transport IEA
Inferred from Electronic Annotation
more info
  
involved_in exocytic insertion of neurotransmitter receptor to postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
  
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in locomotory behavior IEA
Inferred from Electronic Annotation
more info
  
involved_in long-term memory IEA
Inferred from Electronic Annotation
more info
  
involved_in long-term synaptic potentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in neurotransmitter receptor internalization IEA
Inferred from Electronic Annotation
more info
  
involved_in neurotransmitter uptake NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of insulin secretion IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in presynaptic dense core vesicle exocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of insulin secretion TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of neuron projection development IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of synapse assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in synaptic vesicle docking NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in synaptic vesicle exocytosis TAS
Traceable Author Statement
more info
 PubMed 
involved_in synaptic vesicle fusion to presynaptic active zone membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic vesicle priming IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of BLOC-1 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SNARE complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SNARE complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of SNARE complex TAS
Traceable Author Statement
more info
 PubMed 
located_in actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in axonal growth cone IEA
Inferred from Electronic Annotation
more info
  
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in extrinsic component of presynaptic membrane IEA
Inferred from Electronic Annotation
more info
  
located_in filopodium IEA
Inferred from Electronic Annotation
more info
  
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
  
located_in growth cone ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in lamellipodium IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in neuron projection ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in photoreceptor inner segment IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in postsynapse IEA
Inferred from Electronic Annotation
more info
  
located_in presynaptic active zone membrane IEA
Inferred from Electronic Annotation
more info
  
located_in presynaptic membrane TAS
Traceable Author Statement
more info
 PubMed 
located_in ribbon synapse IEA
Inferred from Electronic Annotation
more info
  
located_in specific granule membrane TAS
Traceable Author Statement
more info
  
located_in synaptic vesicle IEA
Inferred from Electronic Annotation
more info
  
part_of synaptobrevin 2-SNAP-25-syntaxin-1a complex IEA
Inferred from Electronic Annotation
more info
  
part_of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex IEA
Inferred from Electronic Annotation
more info
  
located_in tertiary granule membrane TAS
Traceable Author Statement
more info
  
located_in trans-Golgi network IEA
Inferred from Electronic Annotation
more info
  
colocalizes_with vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
part_of voltage-gated potassium channel complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
synaptosomal-associated protein 25
Names
resistance to inhibitors of cholinesterase 4 homolog
synaptosomal-associated protein, 25kDa
synaptosome associated protein 25kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029626.1 RefSeqGene

    Range
    5002..93590
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001322902.2 → NP_001309831.1  synaptosomal-associated protein 25 isoform SNAP25A

    Status: REVIEWED

    Source sequence(s)
    AL023913, AL354824
    Consensus CDS
    CCDS13109.1
    UniProtKB/Swiss-Prot
    P60880
    Related
    ENSP00000516314.1, ENST00000706269.1
    Conserved Domains (3) summary
    cd15885
    Location:143 → 201
    SNARE_SNAP25C; C-terminal SNARE motif of SNAP25
    cd15894
    Location:10 → 82
    SNARE_SNAP25N; N-terminal SNARE motif of SNAP25
    pfam00835
    Location:91 → 141
    SNAP-25; SNAP-25 family

  2. NM_001322903.2 → NP_001309832.1  synaptosomal-associated protein 25 isoform SNAP25B

    Status: REVIEWED

    Source sequence(s)
    AL023913, AL354824
    Consensus CDS
    CCDS13110.1
    UniProtKB/Swiss-Prot
    B2RAU4, D3DW16, D3DW17, P13795, P36974, P60880, P70557, P70558, Q53EM2, Q5U0B5, Q8IXK3, Q96FM2, Q9BR45
    Related
    ENSP00000508541.1, ENST00000691665.1
    Conserved Domains (3) summary
    cd15885
    Location:143 → 201
    SNARE_SNAP25C; C-terminal SNARE motif of SNAP25
    cd15894
    Location:10 → 82
    SNARE_SNAP25N; N-terminal SNARE motif of SNAP25
    pfam00835
    Location:91 → 141
    SNAP-25; SNAP-25 family

  3. NM_001322904.2 → NP_001309833.1  synaptosomal-associated protein 25 isoform SNAP25B

    Status: REVIEWED

    Source sequence(s)
    AL023913, AL354824
    Consensus CDS
    CCDS13110.1
    UniProtKB/Swiss-Prot
    B2RAU4, D3DW16, D3DW17, P13795, P36974, P60880, P70557, P70558, Q53EM2, Q5U0B5, Q8IXK3, Q96FM2, Q9BR45
    Related
    ENSP00000510558.1, ENST00000693325.1
    Conserved Domains (3) summary
    cd15885
    Location:143 → 201
    SNARE_SNAP25C; C-terminal SNARE motif of SNAP25
    cd15894
    Location:10 → 82
    SNARE_SNAP25N; N-terminal SNARE motif of SNAP25
    pfam00835
    Location:91 → 141
    SNAP-25; SNAP-25 family

  4. NM_001322905.2 → NP_001309834.1  synaptosomal-associated protein 25 isoform SNAP25B

    Status: REVIEWED

    Source sequence(s)
    AL023913, AL354824
    Consensus CDS
    CCDS13110.1
    UniProtKB/Swiss-Prot
    B2RAU4, D3DW16, D3DW17, P13795, P36974, P60880, P70557, P70558, Q53EM2, Q5U0B5, Q8IXK3, Q96FM2, Q9BR45
    Related
    ENSP00000510663.1, ENST00000689858.1
    Conserved Domains (3) summary
    cd15885
    Location:143 → 201
    SNARE_SNAP25C; C-terminal SNARE motif of SNAP25
    cd15894
    Location:10 → 82
    SNARE_SNAP25N; N-terminal SNARE motif of SNAP25
    pfam00835
    Location:91 → 141
    SNAP-25; SNAP-25 family

  5. NM_001322906.2 → NP_001309835.1  synaptosomal-associated protein 25 isoform SNAP25B

    Status: REVIEWED

    Source sequence(s)
    AL023913, AL354824
    Consensus CDS
    CCDS13110.1
    UniProtKB/Swiss-Prot
    B2RAU4, D3DW16, D3DW17, P13795, P36974, P60880, P70557, P70558, Q53EM2, Q5U0B5, Q8IXK3, Q96FM2, Q9BR45
    Related
    ENSP00000508837.1, ENST00000685131.1
    Conserved Domains (3) summary
    cd15885
    Location:143 → 201
    SNARE_SNAP25C; C-terminal SNARE motif of SNAP25
    cd15894
    Location:10 → 82
    SNARE_SNAP25N; N-terminal SNARE motif of SNAP25
    pfam00835
    Location:91 → 141
    SNAP-25; SNAP-25 family

  6. NM_001322907.2 → NP_001309836.1  synaptosomal-associated protein 25 isoform SNAP25B

    Status: REVIEWED

    Source sequence(s)
    AL023913, AL354824
    Consensus CDS
    CCDS13110.1
    UniProtKB/Swiss-Prot
    B2RAU4, D3DW16, D3DW17, P13795, P36974, P60880, P70557, P70558, Q53EM2, Q5U0B5, Q8IXK3, Q96FM2, Q9BR45
    Related
    ENSP00000510109.1, ENST00000691161.1
    Conserved Domains (3) summary
    cd15885
    Location:143 → 201
    SNARE_SNAP25C; C-terminal SNARE motif of SNAP25
    cd15894
    Location:10 → 82
    SNARE_SNAP25N; N-terminal SNARE motif of SNAP25
    pfam00835
    Location:91 → 141
    SNAP-25; SNAP-25 family

  7. NM_001322908.2 → NP_001309837.1  synaptosomal-associated protein 25 isoform SNAP25B

    Status: REVIEWED

    Source sequence(s)
    AL023913, AL354824
    Consensus CDS
    CCDS13110.1
    UniProtKB/Swiss-Prot
    B2RAU4, D3DW16, D3DW17, P13795, P36974, P60880, P70557, P70558, Q53EM2, Q5U0B5, Q8IXK3, Q96FM2, Q9BR45
    Related
    ENSP00000510219.1, ENST00000687785.1
    Conserved Domains (3) summary
    cd15885
    Location:143 → 201
    SNARE_SNAP25C; C-terminal SNARE motif of SNAP25
    cd15894
    Location:10 → 82
    SNARE_SNAP25N; N-terminal SNARE motif of SNAP25
    pfam00835
    Location:91 → 141
    SNAP-25; SNAP-25 family

  8. NM_001322909.2 → NP_001309838.1  synaptosomal-associated protein 25 isoform SNAP25B

    Status: REVIEWED

    Source sequence(s)
    AL023913, AL354824
    Consensus CDS
    CCDS13110.1
    UniProtKB/Swiss-Prot
    B2RAU4, D3DW16, D3DW17, P13795, P36974, P60880, P70557, P70558, Q53EM2, Q5U0B5, Q8IXK3, Q96FM2, Q9BR45
    Conserved Domains (3) summary
    cd15885
    Location:143 → 201
    SNARE_SNAP25C; C-terminal SNARE motif of SNAP25
    cd15894
    Location:10 → 82
    SNARE_SNAP25N; N-terminal SNARE motif of SNAP25
    pfam00835
    Location:91 → 141
    SNAP-25; SNAP-25 family

  9. NM_001322910.2 → NP_001309839.1  synaptosomal-associated protein 25 isoform SNAP25B

    Status: REVIEWED

    Source sequence(s)
    AL023913, AL354824
    Consensus CDS
    CCDS13110.1
    UniProtKB/Swiss-Prot
    B2RAU4, D3DW16, D3DW17, P13795, P36974, P60880, P70557, P70558, Q53EM2, Q5U0B5, Q8IXK3, Q96FM2, Q9BR45
    Conserved Domains (3) summary
    cd15885
    Location:143 → 201
    SNARE_SNAP25C; C-terminal SNARE motif of SNAP25
    cd15894
    Location:10 → 82
    SNARE_SNAP25N; N-terminal SNARE motif of SNAP25
    pfam00835
    Location:91 → 141
    SNAP-25; SNAP-25 family

  10. NM_001424415.1 → NP_001411344.1  synaptosomal-associated protein 25 isoform SNAP25A

    Status: REVIEWED

    Source sequence(s)
    AL023913, AL354824

  11. NM_001424416.1 → NP_001411345.1  synaptosomal-associated protein 25 isoform SNAP25B

    Status: REVIEWED

    Source sequence(s)
    AL023913, AL354824
    UniProtKB/Swiss-Prot
    B2RAU4, D3DW16, D3DW17, P13795, P36974, P60880, P70557, P70558, Q53EM2, Q5U0B5, Q8IXK3, Q96FM2, Q9BR45
    Related
    ENSP00000509759.1, ENST00000691353.1

  12. NM_003081.5 → NP_003072.2  synaptosomal-associated protein 25 isoform SNAP25A

    See identical proteins and their annotated locations for NP_003072.2

    Status: REVIEWED

    Source sequence(s)
    AL023913, AL354824
    Consensus CDS
    CCDS13109.1
    UniProtKB/Swiss-Prot
    P60880
    Related
    ENSP00000307341.2, ENST00000304886.6
    Conserved Domains (3) summary
    cd15885
    Location:143 → 201
    SNARE_SNAP25C; C-terminal SNARE motif of SNAP25
    cd15894
    Location:10 → 82
    SNARE_SNAP25N; N-terminal SNARE motif of SNAP25
    pfam00835
    Location:91 → 141
    SNAP-25; SNAP-25 family

  13. NM_130811.4 → NP_570824.1  synaptosomal-associated protein 25 isoform SNAP25B

    See identical proteins and their annotated locations for NP_570824.1

    Status: REVIEWED

    Source sequence(s)
    AL023913, AL354824
    Consensus CDS
    CCDS13110.1
    UniProtKB/Swiss-Prot
    B2RAU4, D3DW16, D3DW17, P13795, P36974, P60880, P70557, P70558, Q53EM2, Q5U0B5, Q8IXK3, Q96FM2, Q9BR45
    Related
    ENSP00000254976.3, ENST00000254976.7
    Conserved Domains (3) summary
    cd15885
    Location:143 → 201
    SNARE_SNAP25C; C-terminal SNARE motif of SNAP25
    cd15894
    Location:10 → 82
    SNARE_SNAP25N; N-terminal SNARE motif of SNAP25
    pfam00835
    Location:91 → 141
    SNAP-25; SNAP-25 family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    10218830..10307418
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017028022.2 → XP_016883511.1  synaptosomal-associated protein 25 isoform X2

    UniProtKB/Swiss-Prot
    P60880
    Conserved Domains (3) summary
    cd15885
    Location:143 → 201
    SNARE_SNAP25C; C-terminal SNARE motif of SNAP25
    cd15894
    Location:10 → 82
    SNARE_SNAP25N; N-terminal SNARE motif of SNAP25
    pfam00835
    Location:91 → 141
    SNAP-25; SNAP-25 family

  2. XM_047440391.1 → XP_047296347.1  synaptosomal-associated protein 25 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    10261695..10350292
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054323888.1 → XP_054179863.1  synaptosomal-associated protein 25 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P60880.1 GenPept UniProtKB/Swiss-Prot:P60880

Gene LinkOut

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Chemical Information
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