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Snap25 synaptosomal-associated protein 25 [ Mus musculus (house mouse) ]

Gene ID: 20614, updated on 18-Apr-2024

Summary

Official Symbol
Snap25provided by MGI
Official Full Name
synaptosomal-associated protein 25provided by MGI
Primary source
MGI:MGI:98331
See related
Ensembl:ENSMUSG00000027273 AllianceGenome:MGI:98331
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
sp; Bdr; SUP; GENA70; SNAP-25
Summary
Enables syntaxin-1 binding activity. Involved in exocytosis; neurotransmitter receptor internalization; and regulation of neuron projection development. Acts upstream of or within several processes, including associative learning; neurotransmitter secretion; and regulation of synaptic plasticity. Located in several cellular components, including glutamatergic synapse; synaptic vesicle; and trans-Golgi network. Is extrinsic component of cytoplasmic side of plasma membrane. Part of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex. Is expressed in adrenal gland; jaw; nervous system; and sensory organ. Used to study attention deficit hyperactivity disorder; obesity; schizophrenia; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Down syndrome and congenital myasthenic syndrome 18. Orthologous to human SNAP25 (synaptosome associated protein 25). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 622.2), cortex adult (RPKM 577.5) and 3 other tissues See more
Orthologs
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Genomic context

Location:
2 F3; 2 67.56 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (136555359..136624348)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (136713439..136782428)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 32746 Neighboring gene predicted gene, 32659 Neighboring gene ankyrin repeat and EF-hand domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_05800 Neighboring gene STARR-seq mESC enhancer starr_05801 Neighboring gene STARR-seq mESC enhancer starr_05804 Neighboring gene predicted gene, 39943 Neighboring gene STARR-seq mESC enhancer starr_05805 Neighboring gene predicted gene, 46767

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables SNAP receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables SNARE binding IDA
Inferred from Direct Assay
more info
PubMed 
enables SNARE binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables calcium-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enables lipid binding ISO
Inferred from Sequence Orthology
more info
 
enables myosin binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables syntaxin-1 binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables syntaxin-1 binding IDA
Inferred from Direct Assay
more info
PubMed 
enables syntaxin-1 binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
 
enables voltage-gated potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in SNARE complex assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within associative learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in calcium ion-regulated exocytosis of neurotransmitter ISO
Inferred from Sequence Orthology
more info
 
involved_in endosomal transport ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of localization in cell ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in exocytic insertion of neurotransmitter receptor to postsynaptic membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in insulin secretion ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in long-term memory ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within long-term synaptic potentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neurotransmitter receptor internalization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neurotransmitter secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of hormone secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in presynaptic dense core vesicle exocytosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in presynaptic dense core vesicle exocytosis IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in presynaptic dense core vesicle exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of establishment of protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of neuron projection development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in synaptic vesicle exocytosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in synaptic vesicle exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synaptic vesicle exocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in synaptic vesicle fusion to presynaptic active zone membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in synaptic vesicle priming IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of BLOC-1 complex ISO
Inferred from Sequence Orthology
more info
 
part_of SNARE complex ISO
Inferred from Sequence Orthology
more info
 
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in axonal growth cone ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in extrinsic component of presynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
located_in filopodium ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in growth cone ISO
Inferred from Sequence Orthology
more info
 
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in myelin sheath HDA PubMed 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
PubMed 
located_in postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in presynapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in presynaptic active zone membrane ISO
Inferred from Sequence Orthology
more info
 
located_in presynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
located_in ribbon synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in somatodendritic compartment IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in synaptic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
part_of synaptobrevin 2-SNAP-25-syntaxin-1a complex ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex ISO
Inferred from Sequence Orthology
more info
 
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with vesicle ISO
Inferred from Sequence Orthology
more info
 
part_of voltage-gated potassium channel complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
synaptosomal-associated protein 25
Names
blind drunk
super protein
synaptosomal-associated 25 kDa protein
synaptosomal-associated protein, 25 kDa

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291056.2NP_001277985.1  synaptosomal-associated protein 25 isoform b

    See identical proteins and their annotated locations for NP_001277985.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon but contains a different in-frame exon in the central coding region, compared to variant 1. The encoded isoform (b) is the same length but contains an alternate internal segment, compared to isoform a.
    Source sequence(s)
    AL732447
    Consensus CDS
    CCDS71153.1
    UniProtKB/Swiss-Prot
    P60879
    Related
    ENSMUSP00000105725.4, ENSMUST00000110098.4
    Conserved Domains (3) summary
    cd15885
    Location:143201
    SNARE_SNAP25C; C-terminal SNARE motif of SNAP25
    cd15894
    Location:1082
    SNARE_SNAP25N; N-terminal SNARE motif of SNAP25
    pfam00835
    Location:91141
    SNAP-25; SNAP-25 family
  2. NM_001355254.1NP_001342183.1  synaptosomal-associated protein 25 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 both encode the same isoform (a).
    Source sequence(s)
    AL732447
    Consensus CDS
    CCDS16793.1
    UniProtKB/Swiss-Prot
    A2AIC2, A2AIC3, P60879
    Conserved Domains (3) summary
    cd15885
    Location:143201
    SNARE_SNAP25C; C-terminal SNARE motif of SNAP25
    cd15894
    Location:1082
    SNARE_SNAP25N; N-terminal SNARE motif of SNAP25
    pfam00835
    Location:91141
    SNAP-25; SNAP-25 family
  3. NM_001355255.2NP_001342184.1  synaptosomal-associated protein 25 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice junction and lacks an in-frame exon but contains a different in-frame exon in the central coding region, compared to variant 1. The encoded isoform (d) is the same length but contains an alternate internal segment, compared to isoform a.
    Source sequence(s)
    AL732447
    Conserved Domains (3) summary
    cd15885
    Location:139197
    SNARE_SNAP25C; C-terminal SNARE motif of SNAP25
    cd15894
    Location:1082
    SNARE_SNAP25N; N-terminal SNARE motif of SNAP25
    pfam00835
    Location:91137
    SNAP-25; SNAP-25 family
  4. NM_001412615.1NP_001399544.1  synaptosomal-associated protein 25 isoform a

    Status: VALIDATED

    Source sequence(s)
    AL732447
    UniProtKB/Swiss-Prot
    A2AIC2, A2AIC3, P60879
  5. NM_001412616.1NP_001399545.1  synaptosomal-associated protein 25 isoform a

    Status: VALIDATED

    Source sequence(s)
    AL732447
    UniProtKB/Swiss-Prot
    A2AIC2, A2AIC3, P60879
  6. NM_001412617.1NP_001399546.1  synaptosomal-associated protein 25 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL732447
  7. NM_001412618.1NP_001399547.1  synaptosomal-associated protein 25 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL732447
  8. NM_001412619.1NP_001399548.1  synaptosomal-associated protein 25 isoform d

    Status: VALIDATED

    Source sequence(s)
    AL732447
  9. NM_001412620.1NP_001399549.1  synaptosomal-associated protein 25 isoform g

    Status: VALIDATED

    Source sequence(s)
    AL732447
  10. NM_001412621.1NP_001399550.1  synaptosomal-associated protein 25 isoform e

    Status: VALIDATED

    Source sequence(s)
    AL732447
  11. NM_001412622.1NP_001399551.1  synaptosomal-associated protein 25 isoform f

    Status: VALIDATED

    Source sequence(s)
    AL732447
  12. NM_011428.4NP_035558.1  synaptosomal-associated protein 25 isoform a

    See identical proteins and their annotated locations for NP_035558.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform a. Variants 1 and 3 both encode the same isoform (a).
    Source sequence(s)
    AL732447
    Consensus CDS
    CCDS16793.1
    UniProtKB/Swiss-Prot
    A2AIC2, A2AIC3, P60879
    Related
    ENSMUSP00000028727.5, ENSMUST00000028727.11
    Conserved Domains (3) summary
    cd15885
    Location:143201
    SNARE_SNAP25C; C-terminal SNARE motif of SNAP25
    cd15894
    Location:1082
    SNARE_SNAP25N; N-terminal SNARE motif of SNAP25
    pfam00835
    Location:91141
    SNAP-25; SNAP-25 family

RNA

  1. NR_149318.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL732447
  2. NR_182008.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL732447
  3. NR_182009.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL732447

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    136555359..136624348
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017316761.2XP_017172250.1  synaptosomal-associated protein 25 isoform X2

    Conserved Domains (3) summary
    cd15885
    Location:80138
    SNARE_SNAP25C; C-terminal SNARE motif of SNAP25
    pfam00835
    Location:2878
    SNAP-25; SNAP-25 family
    cl22856
    Location:119
    SNARE; SNARE motif