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ZBTB10 zinc finger and BTB domain containing 10 [ Homo sapiens (human) ]

Gene ID: 65986, updated on 25-Nov-2021

Summary

Official Symbol
ZBTB10provided by HGNC
Official Full Name
zinc finger and BTB domain containing 10provided by HGNC
Primary source
HGNC:HGNC:30953
See related
Ensembl:ENSG00000205189 MIM:618576
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RINZF
Expression
Ubiquitous expression in prostate (RPKM 6.2), placenta (RPKM 5.4) and 25 other tissues See more
Orthologs
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Genomic context

See ZBTB10 in Genome Data Viewer
Location:
8q21.13
Exon count:
7
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (80485593..80526265)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (81397828..81438500)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375922 Neighboring gene uncharacterized LOC105375921 Neighboring gene RNA, U7 small nuclear 174 pseudogene Neighboring gene ribosomal protein SA pseudogene 47

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation.
GeneReviews: Not available
A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
GeneReviews: Not available
Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype.
GeneReviews: Not available
Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis.
GeneReviews: Not available
Novel associations for hypothyroidism include known autoimmune risk loci.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12752

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISS
Inferred from Sequence or Structural Similarity
more info
 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables telomeric DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in chromosome, telomeric region IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger and BTB domain-containing protein 10
Names
zinc finger protein RIN ZF
zinc finger protein RINZF

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105539.3NP_001099009.1  zinc finger and BTB domain-containing protein 10 isoform a

    See identical proteins and their annotated locations for NP_001099009.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC009812, AI627858, BC050061, BC127098
    Consensus CDS
    CCDS47880.1
    UniProtKB/Swiss-Prot
    Q96DT7
    Related
    ENSP00000412036.3, ENST00000455036.8
    Conserved Domains (5) summary
    smart00597
    Location:249316
    ZnF_TTF; zinc finger in transposases and transcription factors
    sd00017
    Location:724744
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18201
    Location:343464
    BTB_POZ_ZBTB10; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10)
    pfam13465
    Location:737761
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:722746
    zf-H2C2_5; C2H2-type zinc-finger domain
  2. NM_001277145.2NP_001264074.1  zinc finger and BTB domain-containing protein 10 isoform c

    See identical proteins and their annotated locations for NP_001264074.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate exon in the 5' UTR and coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (c) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AC009812, AI627858, AK056913
    Consensus CDS
    CCDS64920.1
    UniProtKB/Swiss-Prot
    Q96DT7
    Related
    ENSP00000368384.4, ENST00000379091.8
    Conserved Domains (4) summary
    sd00017
    Location:432452
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl38908
    Location:51172
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    pfam13465
    Location:445469
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:430454
    zf-H2C2_5; C2H2-type zinc-finger domain
  3. NM_023929.5NP_076418.3  zinc finger and BTB domain-containing protein 10 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks a segment in an internal exon, but maintains the reading frame, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AC009812, AI627858, AK022814, BC127098
    UniProtKB/Swiss-Prot
    Q96DT7
    UniProtKB/TrEMBL
    Q9H9H3
    Related
    ENSP00000416134.2, ENST00000426744.5
    Conserved Domains (6) summary
    smart00225
    Location:365461
    BTB; Broad-Complex, Tramtrack and Bric a brac
    smart00597
    Location:249316
    ZnF_TTF; zinc finger in transposases and transcription factors
    sd00017
    Location:700720
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:354460
    BTB; BTB/POZ domain
    pfam13465
    Location:713737
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:698720
    zf-H2C2_5; C2H2-type zinc-finger domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    80485593..80526265
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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