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SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 [ Homo sapiens (human) ]

Gene ID: 6597, updated on 5-Apr-2020

Summary

Official Symbol
SMARCA4provided by HGNC
Official Full Name
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4provided by HGNC
Primary source
HGNC:HGNC:11100
See related
Ensembl:ENSG00000127616 MIM:603254
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BRG1; CSS4; SNF2; SWI2; MRD16; RTPS2; BAF190; SNF2L4; SNF2LB; hSNF2b; BAF190A; SNF2-beta
Summary
The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Expression
Ubiquitous expression in testis (RPKM 21.8), brain (RPKM 14.5) and 25 other tissues See more
Orthologs

Genomic context

See SMARCA4 in Genome Data Viewer
Location:
19p13.2
Exon count:
40
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (10960997..11062277)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (11071598..11172958)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene coactivator associated arginine methyltransferase 1 Neighboring gene Yip1 domain family member 2 Neighboring gene translocase of inner mitochondrial membrane 29 Neighboring gene RNA, 7SL, cytoplasmic 192, pseudogene Neighboring gene LDLR-AS1 Neighboring gene low density lipoprotein receptor Neighboring gene microRNA 6886

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Mental retardation, autosomal dominant 16
MedGen: C3553249 OMIM: 614609 GeneReviews: Not available
Compare labs
Rhabdoid tumor predisposition syndrome 2 Compare labs

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated (2013-09-04)

ClinGen Genome Curation Page
Haploinsufficency

Some evidence for dosage pathogenicity (Last evaluated (2013-09-04)

ClinGen Genome Curation PagePubMed

NHGRI GWAS Catalog

Description
Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants.
NHGRI GWA Catalog
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
NHGRI GWA Catalog
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
NHGRI GWA Catalog
Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Most of the components of the SWI2/SNF2 chromatin remodeling complex (BRG1/BRM, BAF250, BAF180, BAF170, BAF155, BAF60a, BAF53A, actin and InI) except BRM, BAF155 and BAF57, are identified to interact with HIV-1 Tat in Jurkat cell PubMed
tat HIV-1 Tat induces phosphorylation of BRG1 and BAF155 PubMed
tat INI-1 and BRG-1 synergize with the p300 acetyltransferase to activate the HIV promoter; this synergism depends on the acetyltransferase activity of p300 and on HIV-1 Tat amino acids Lys(50) and Lys(51), suggesting a regulation of Tat by these proteins PubMed
tat Acetylated HIV-1 Tat binds efficiently to BRG1 and BAF200 (component of PBAF complex) and weakly to BAF250 (component of BAF complex) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ39786

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA polymerase binding IPI
Inferred from Physical Interaction
more info
PubMed 
DNA-dependent ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-dependent ATPase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
RNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase I CORE element sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to RNA polymerase II proximal promoter sequence-specific DNA binding HDA PubMed 
Tat protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
androgen receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
helicase activity IEA
Inferred from Electronic Annotation
more info
 
lysine-acetylated histone binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to nucleosomal DNA binding HDA PubMed 
p53 binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein N-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription coactivator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription coactivator activity NAS
Non-traceable Author Statement
more info
PubMed 
transcription corepressor activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
ATP-dependent chromatin remodeling HDA PubMed 
ATP-dependent chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase I preinitiation complex assembly IEA
Inferred from Electronic Annotation
more info
 
beta-catenin-TCF complex assembly TAS
Traceable Author Statement
more info
 
chromatin organization TAS
Traceable Author Statement
more info
 
chromatin remodeling IC
Inferred by Curator
more info
PubMed 
chromatin remodeling IDA
Inferred from Direct Assay
more info
PubMed 
chromatin remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
interleukin-7-mediated signaling pathway TAS
Traceable Author Statement
more info
 
negative regulation of androgen receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
nervous system development IEA
Inferred from Electronic Annotation
more info
 
neural retina development IEP
Inferred from Expression Pattern
more info
PubMed 
nucleosome disassembly IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation by host of viral transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of glucose mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of pri-miRNA transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription of nucleolar large rRNA by RNA polymerase I IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
SWI/SNF complex IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space HDA PubMed 
membrane HDA PubMed 
nBAF complex ISS
Inferred from Sequence or Structural Similarity
more info
 
npBAF complex IDA
Inferred from Direct Assay
more info
PubMed 
npBAF complex ISS
Inferred from Sequence or Structural Similarity
more info
 
nuclear chromatin HDA PubMed 
nuclear chromatin IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex HDA PubMed 

General protein information

Preferred Names
transcription activator BRG1
Names
ATP-dependent helicase SMARCA4
BRG1-associated factor 190A
BRM/SWI2-related gene 1
SNF2-like 4
brahma protein-like 1
global transcription activator homologous sequence
homeotic gene regulator
mitotic growth and transcription activator
nuclear protein GRB1
protein BRG-1
protein brahma homolog 1
sucrose nonfermenting-like 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011556.2 RefSeqGene

    Range
    5109..106547
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001128844.3NP_001122316.1  transcription activator BRG1 isoform B

    See identical proteins and their annotated locations for NP_001122316.1

    Status: REVIEWED

    Source sequence(s)
    AC006127, AC011442, AC011485
    Consensus CDS
    CCDS12253.1
    UniProtKB/Swiss-Prot
    P51532
    UniProtKB/TrEMBL
    A7E2E1
    Related
    ENSP00000395654.1, ENST00000429416.8
    Conserved Domains (9) summary
    cd05516
    Location:14581564
    Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
    smart00592
    Location:612656
    BRK; domain in transcription and CHROMO domain helicases
    smart00573
    Location:460532
    HSA; domain in helicases and associated with SANT domains
    PLN03142
    Location:7501232
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    COG1196
    Location:370552
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam09606
    Location:42222
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam08880
    Location:171205
    QLQ
    pfam14619
    Location:13221389
    SnAC; Snf2-ATP coupling, chromatin remodelling complex
    cd18062
    Location:731981
    DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
  2. NM_001128845.2NP_001122317.1  transcription activator BRG1 isoform C

    See identical proteins and their annotated locations for NP_001122317.1

    Status: REVIEWED

    Source sequence(s)
    AC006127, AC011442, AC011485
    Consensus CDS
    CCDS45972.1
    UniProtKB/Swiss-Prot
    P51532
    UniProtKB/TrEMBL
    B3KNW7
    Related
    ENSP00000414727.3, ENST00000413806.7
    Conserved Domains (8) summary
    cd05516
    Location:14281534
    Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
    smart00592
    Location:612656
    BRK; domain in transcription and CHROMO domain helicases
    smart00573
    Location:460532
    HSA; domain in helicases and associated with SANT domains
    pfam08880
    Location:171205
    QLQ; QLQ
    pfam09606
    Location:42222
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam14619
    Location:12891356
    SnAC; Snf2-ATP coupling, chromatin remodelling complex
    cl25732
    Location:370552
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26465
    Location:7501232
    SNF2_N; SNF2 family N-terminal domain
  3. NM_001128846.2NP_001122318.1  transcription activator BRG1 isoform D

    See identical proteins and their annotated locations for NP_001122318.1

    Status: REVIEWED

    Source sequence(s)
    AC006127, AC011442, AC011485
    Consensus CDS
    CCDS45973.1
    UniProtKB/Swiss-Prot
    P51532
    UniProtKB/TrEMBL
    B3KNW7
    Related
    ENSP00000464778.1, ENST00000589677.5
    Conserved Domains (8) summary
    cd05516
    Location:14281533
    Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
    smart00592
    Location:612656
    BRK; domain in transcription and CHROMO domain helicases
    smart00573
    Location:460532
    HSA; domain in helicases and associated with SANT domains
    pfam08880
    Location:171205
    QLQ; QLQ
    pfam09606
    Location:42222
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam14619
    Location:12891356
    SnAC; Snf2-ATP coupling, chromatin remodelling complex
    cl25732
    Location:370552
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26465
    Location:7501232
    SNF2_N; SNF2 family N-terminal domain
  4. NM_001128847.4NP_001122319.1  transcription activator BRG1 isoform E

    See identical proteins and their annotated locations for NP_001122319.1

    Status: REVIEWED

    Source sequence(s)
    AC006127, AC011442, AC011485
    Consensus CDS
    CCDS54217.1
    UniProtKB/Swiss-Prot
    P51532
    UniProtKB/TrEMBL
    B3KNW7
    Related
    ENSP00000494676.1, ENST00000647230.1
    Conserved Domains (9) summary
    cd05516
    Location:14251531
    Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
    smart00592
    Location:612656
    BRK; domain in transcription and CHROMO domain helicases
    smart00573
    Location:460532
    HSA; domain in helicases and associated with SANT domains
    PLN03142
    Location:7501232
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    COG1196
    Location:370552
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam09606
    Location:42222
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam08880
    Location:171205
    QLQ
    pfam14619
    Location:12891356
    SnAC; Snf2-ATP coupling, chromatin remodelling complex
    cd18062
    Location:731981
    DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
  5. NM_001128848.2NP_001122320.1  transcription activator BRG1 isoform F

    See identical proteins and their annotated locations for NP_001122320.1

    Status: REVIEWED

    Source sequence(s)
    AC006127, AC011442, AC011485
    Consensus CDS
    CCDS54218.1
    UniProtKB/Swiss-Prot
    P51532
    UniProtKB/TrEMBL
    B3KNW7
    Related
    ENSP00000392837.2, ENST00000444061.8
    Conserved Domains (9) summary
    cd05516
    Location:14251530
    Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
    smart00592
    Location:612656
    BRK; domain in transcription and CHROMO domain helicases
    smart00573
    Location:460532
    HSA; domain in helicases and associated with SANT domains
    PLN03142
    Location:7501232
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    COG1196
    Location:370552
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam09606
    Location:42222
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam08880
    Location:171205
    QLQ
    pfam14619
    Location:12891356
    SnAC; Snf2-ATP coupling, chromatin remodelling complex
    cd18062
    Location:731981
    DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
  6. NM_001128849.3NP_001122321.1  transcription activator BRG1 isoform A

    See identical proteins and their annotated locations for NP_001122321.1

    Status: REVIEWED

    Source sequence(s)
    AC006127, AC011442, AC011485
    UniProtKB/TrEMBL
    Q9HBD4
    Related
    ENSP00000397783.3, ENST00000450717.7
    Conserved Domains (9) summary
    cd05516
    Location:14901596
    Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
    smart00592
    Location:612656
    BRK; domain in transcription and CHROMO domain helicases
    smart00573
    Location:460532
    HSA; domain in helicases and associated with SANT domains
    PLN03142
    Location:7501232
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    COG1196
    Location:370552
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam09606
    Location:42222
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam08880
    Location:171205
    QLQ
    pfam14619
    Location:13221389
    SnAC; Snf2-ATP coupling, chromatin remodelling complex
    cd18062
    Location:731981
    DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
  7. NM_001374457.1NP_001361386.1  transcription activator BRG1 isoform E

    Status: REVIEWED

    Source sequence(s)
    AC006127, AC011442, AC011485
    Related
    ENSP00000495536.1, ENST00000646484.1
  8. NM_003072.5NP_003063.2  transcription activator BRG1 isoform B

    See identical proteins and their annotated locations for NP_003063.2

    Status: REVIEWED

    Source sequence(s)
    AC006127, AC011442, AC011485
    Consensus CDS
    CCDS12253.1
    UniProtKB/Swiss-Prot
    P51532
    UniProtKB/TrEMBL
    A7E2E1
    Related
    ENSP00000343896.4, ENST00000344626.9
    Conserved Domains (9) summary
    cd05516
    Location:14581564
    Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
    smart00592
    Location:612656
    BRK; domain in transcription and CHROMO domain helicases
    smart00573
    Location:460532
    HSA; domain in helicases and associated with SANT domains
    PLN03142
    Location:7501232
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    COG1196
    Location:370552
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam09606
    Location:42222
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam08880
    Location:171205
    QLQ
    pfam14619
    Location:13221389
    SnAC; Snf2-ATP coupling, chromatin remodelling complex
    cd18062
    Location:731981
    DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4

RNA

  1. NR_164683.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC006127, AC011442, AC011485

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    10960997..11062277
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006722845.2XP_006722908.1  transcription activator BRG1 isoform X1

    See identical proteins and their annotated locations for XP_006722908.1

    UniProtKB/TrEMBL
    Q9HBD4
    Related
    ENSP00000495368.1, ENST00000646693.1
    Conserved Domains (9) summary
    cd05516
    Location:14901596
    Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
    smart00592
    Location:612656
    BRK; domain in transcription and CHROMO domain helicases
    smart00573
    Location:460532
    HSA; domain in helicases and associated with SANT domains
    PLN03142
    Location:7501232
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    COG1196
    Location:370552
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam09606
    Location:42222
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam08880
    Location:171205
    QLQ
    pfam14619
    Location:13221389
    SnAC; Snf2-ATP coupling, chromatin remodelling complex
    cd18062
    Location:731981
    DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
  2. XM_024451659.1XP_024307427.1  transcription activator BRG1 isoform X2

    Conserved Domains (8) summary
    cd05516
    Location:14901595
    Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
    smart00592
    Location:612656
    BRK; domain in transcription and CHROMO domain helicases
    smart00573
    Location:460532
    HSA; domain in helicases and associated with SANT domains
    pfam08880
    Location:171205
    QLQ; QLQ
    pfam09606
    Location:42222
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam14619
    Location:13221389
    SnAC; Snf2-ATP coupling, chromatin remodelling complex
    cl25732
    Location:370552
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26465
    Location:7501232
    SNF2_N; SNF2 family N-terminal domain
  3. XM_024451660.1XP_024307428.1  transcription activator BRG1 isoform X3

    Related
    ENSP00000496004.1, ENST00000643995.1
    Conserved Domains (9) summary
    cd05516
    Location:14611567
    Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
    smart00592
    Location:612656
    BRK; domain in transcription and CHROMO domain helicases
    smart00573
    Location:460532
    HSA; domain in helicases and associated with SANT domains
    PLN03142
    Location:7501232
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    COG1196
    Location:370552
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam09606
    Location:42222
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam08880
    Location:171205
    QLQ
    pfam14619
    Location:13221389
    SnAC; Snf2-ATP coupling, chromatin remodelling complex
    cd18062
    Location:731981
    DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
  4. XM_024451662.1XP_024307430.1  transcription activator BRG1 isoform X5

    Conserved Domains (9) summary
    cd05516
    Location:14581563
    Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
    smart00592
    Location:612656
    BRK; domain in transcription and CHROMO domain helicases
    smart00573
    Location:460532
    HSA; domain in helicases and associated with SANT domains
    PLN03142
    Location:7501232
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    COG1196
    Location:370552
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam09606
    Location:42222
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam08880
    Location:171205
    QLQ
    pfam14619
    Location:13221389
    SnAC; Snf2-ATP coupling, chromatin remodelling complex
    cd18062
    Location:731981
    DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
  5. XM_024451661.1XP_024307429.1  transcription activator BRG1 isoform X4

    Related
    ENSP00000496498.1, ENST00000642628.1
    Conserved Domains (9) summary
    cd05516
    Location:14571563
    Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
    smart00592
    Location:612656
    BRK; domain in transcription and CHROMO domain helicases
    smart00573
    Location:460532
    HSA; domain in helicases and associated with SANT domains
    PLN03142
    Location:7501232
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    COG1196
    Location:370552
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam09606
    Location:42222
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam08880
    Location:171205
    QLQ
    pfam14619
    Location:12891356
    SnAC; Snf2-ATP coupling, chromatin remodelling complex
    cd18062
    Location:731981
    DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
  6. XM_024451663.1XP_024307431.1  transcription activator BRG1 isoform X6

    Conserved Domains (8) summary
    cd05516
    Location:14571562
    Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
    smart00592
    Location:612656
    BRK; domain in transcription and CHROMO domain helicases
    smart00573
    Location:460532
    HSA; domain in helicases and associated with SANT domains
    pfam08880
    Location:171205
    QLQ; QLQ
    pfam09606
    Location:42222
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam14619
    Location:12891356
    SnAC; Snf2-ATP coupling, chromatin remodelling complex
    cl25732
    Location:370552
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26465
    Location:7501232
    SNF2_N; SNF2 family N-terminal domain
  7. XM_024451664.1XP_024307432.1  transcription activator BRG1 isoform X7

    Related
    ENSP00000496635.1, ENST00000643296.1
    Conserved Domains (8) summary
    cd05516
    Location:14281534
    Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
    smart00592
    Location:612656
    BRK; domain in transcription and CHROMO domain helicases
    smart00573
    Location:460532
    HSA; domain in helicases and associated with SANT domains
    pfam08880
    Location:171205
    QLQ; QLQ
    pfam09606
    Location:42222
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam14619
    Location:12891356
    SnAC; Snf2-ATP coupling, chromatin remodelling complex
    cl25732
    Location:370552
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26465
    Location:7501232
    SNF2_N; SNF2 family N-terminal domain
  8. XM_024451665.1XP_024307433.1  transcription activator BRG1 isoform X8

    Conserved Domains (8) summary
    cd05516
    Location:14281533
    Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
    smart00592
    Location:612656
    BRK; domain in transcription and CHROMO domain helicases
    smart00573
    Location:460532
    HSA; domain in helicases and associated with SANT domains
    pfam08880
    Location:171205
    QLQ; QLQ
    pfam09606
    Location:42222
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam14619
    Location:12891356
    SnAC; Snf2-ATP coupling, chromatin remodelling complex
    cl25732
    Location:370552
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26465
    Location:7501232
    SNF2_N; SNF2 family N-terminal domain
  9. XM_024451667.1XP_024307435.1  transcription activator BRG1 isoform X10

    Related
    ENSP00000494463.1, ENST00000645460.1
    Conserved Domains (9) summary
    cd05516
    Location:14251530
    Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
    smart00592
    Location:612656
    BRK; domain in transcription and CHROMO domain helicases
    smart00573
    Location:460532
    HSA; domain in helicases and associated with SANT domains
    PLN03142
    Location:7501232
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    COG1196
    Location:370552
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam09606
    Location:42222
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam08880
    Location:171205
    QLQ
    pfam14619
    Location:12891356
    SnAC; Snf2-ATP coupling, chromatin remodelling complex
    cd18062
    Location:731981
    DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
  10. XM_011528198.1XP_011526500.1  transcription activator BRG1 isoform X1

    See identical proteins and their annotated locations for XP_011526500.1

    UniProtKB/TrEMBL
    Q9HBD4
    Conserved Domains (9) summary
    cd05516
    Location:14901596
    Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
    smart00592
    Location:612656
    BRK; domain in transcription and CHROMO domain helicases
    smart00573
    Location:460532
    HSA; domain in helicases and associated with SANT domains
    PLN03142
    Location:7501232
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    COG1196
    Location:370552
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam09606
    Location:42222
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam08880
    Location:171205
    QLQ
    pfam14619
    Location:13221389
    SnAC; Snf2-ATP coupling, chromatin remodelling complex
    cd18062
    Location:731981
    DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
  11. XM_024451658.1XP_024307426.1  transcription activator BRG1 isoform X1

    Conserved Domains (9) summary
    cd05516
    Location:14901596
    Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
    smart00592
    Location:612656
    BRK; domain in transcription and CHROMO domain helicases
    smart00573
    Location:460532
    HSA; domain in helicases and associated with SANT domains
    PLN03142
    Location:7501232
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    COG1196
    Location:370552
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam09606
    Location:42222
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam08880
    Location:171205
    QLQ
    pfam14619
    Location:13221389
    SnAC; Snf2-ATP coupling, chromatin remodelling complex
    cd18062
    Location:731981
    DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
  12. XM_006722846.2XP_006722909.1  transcription activator BRG1 isoform X1

    See identical proteins and their annotated locations for XP_006722909.1

    UniProtKB/TrEMBL
    Q9HBD4
    Conserved Domains (9) summary
    cd05516
    Location:14901596
    Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
    smart00592
    Location:612656
    BRK; domain in transcription and CHROMO domain helicases
    smart00573
    Location:460532
    HSA; domain in helicases and associated with SANT domains
    PLN03142
    Location:7501232
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    COG1196
    Location:370552
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam09606
    Location:42222
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam08880
    Location:171205
    QLQ
    pfam14619
    Location:13221389
    SnAC; Snf2-ATP coupling, chromatin remodelling complex
    cd18062
    Location:731981
    DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
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