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Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 [ Mus musculus (house mouse) ]

Gene ID: 20586, updated on 29-Jan-2023

Summary

Official Symbol
Smarca4provided by MGI
Official Full Name
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4provided by MGI
Primary source
MGI:MGI:88192
See related
Ensembl:ENSMUSG00000032187 AllianceGenome:MGI:88192
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Brg1; BAF190A; SW1/SNF; HP1-BP72; SNF2beta; b2b692Clo; b2b508.1Clo
Summary
Enables several functions, including ATP hydrolysis activity; DNA polymerase binding activity; and nucleic acid binding activity. Involved in nervous system development; positive regulation of Wnt signaling pathway; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within with a negative effect on gene expression. Acts upstream of or within several processes, including animal organ development; blastocyst development; and circulatory system development. Located in euchromatin; heterochromatin; and perichromatin fibrils. Part of SWI/SNF complex; nBAF complex; and npBAF complex. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; nervous system; and sensory organ. Used to study breast cancer. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 4; hepatocellular carcinoma; lung non-small cell carcinoma; and rhabdoid cancer. Orthologous to human SMARCA4 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 48.7), CNS E14 (RPKM 45.5) and 28 other tissues See more
Orthologs
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Try the new Transcript table

Genomic context

See Smarca4 in Genome Data Viewer
Location:
9 A3; 9 7.84 cM
Exon count:
37
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (21527377..21615526)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (21616106..21704230)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene 7904 Neighboring gene microRNA 1946b Neighboring gene predicted gene, 26511 Neighboring gene low density lipoprotein receptor

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables ATP hydrolysis activity TAS
Traceable Author Statement
more info
PubMed 
enables ATP-dependent activity, acting on DNA IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ATP-dependent activity, acting on DNA ISO
Inferred from Sequence Orthology
more info
 
enables ATP-dependent chromatin remodeler activity IC
Inferred by Curator
more info
PubMed 
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA polymerase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables DNA polymerase binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to RNA polymerase I core promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables Tat protein binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone binding IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables lncRNA binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables lysine-acetylated histone binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear androgen receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables p53 binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription coregulator binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA methylation on cytosine within a CG sequence IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within DNA methylation-dependent heterochromatin formation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within aorta development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within aortic smooth muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within blastocyst growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within blastocyst hatching IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within blood vessel development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within chromatin remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
 
involved_in chromatin remodeling NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within coronary vasculature development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within definitive erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic hindlimb morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic organ morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within epidermis morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within extracellular matrix organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within forebrain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within_negative_effect gene expression IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within glial cell fate determination IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heart trabecula formation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within hindbrain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within histone H3 acetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within keratinocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lens fiber cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within liver development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of androgen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell differentiation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neurogenesis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within nucleosome assembly TAS
Traceable Author Statement
more info
PubMed 
involved_in nucleosome disassembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within outflow tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within pharyngeal arch artery morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation by host of viral transcription ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of DNA binding IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T cell differentiation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell differentiation NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell population proliferation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of cold-induced thermogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of double-strand break repair NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of glucose mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of miRNA transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of myoblast differentiation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of stem cell population maintenance NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription of nucleolar large rRNA by RNA polymerase I ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within primitive erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of G0 to G1 transition NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of G1/S transition of mitotic cell cycle NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of mitotic metaphase/anaphase transition NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of nucleotide-excision repair NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in transcription initiation-coupled chromatin remodeling IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within vasculogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ventricular septum development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of GBAF complex NAS
Non-traceable Author Statement
more info
PubMed 
part_of RSC-type complex NAS
Non-traceable Author Statement
more info
PubMed 
part_of SWI/SNF complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of SWI/SNF complex ISO
Inferred from Sequence Orthology
more info
 
part_of SWI/SNF complex NAS
Non-traceable Author Statement
more info
PubMed 
part_of SWI/SNF complex TAS
Traceable Author Statement
more info
PubMed 
part_of SWI/SNF superfamily-type complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of bBAF complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in chromatin NAS
Non-traceable Author Statement
more info
PubMed 
located_in euchromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
 
located_in heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in kinetochore NAS
Non-traceable Author Statement
more info
PubMed 
located_in male germ cell nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of nBAF complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of nBAF complex NAS
Non-traceable Author Statement
more info
PubMed 
part_of npBAF complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of npBAF complex ISO
Inferred from Sequence Orthology
more info
 
part_of npBAF complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in nuclear matrix NAS
Non-traceable Author Statement
more info
PubMed 
NOT located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perichromatin fibrils IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
transcription activator BRG1
Names
ATP-dependent helicase SMARCA4
BRG1-associated factor 190A
SNF2-beta
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4
protein brahma homolog 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001174078.1NP_001167549.1  transcription activator BRG1 isoform 1

    See identical proteins and their annotated locations for NP_001167549.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks an alternate in-frame exon and uses an alternate in-frame splice junction compared to variant 4. The resulting isoform (1) has the same N- and C-termini but is shorter compared to isoform 4.
    Source sequence(s)
    AK160825, BC079560
    Consensus CDS
    CCDS52737.1
    UniProtKB/Swiss-Prot
    Q3TKT4
    UniProtKB/TrEMBL
    A0A0R4J170, A0A6P5Q5T1
    Related
    ENSMUSP00000096547.4, ENSMUST00000098948.10
    Conserved Domains (9) summary
    cd05516
    Location:14281534
    Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
    smart00592
    Location:612656
    BRK; domain in transcription and CHROMO domain helicases
    PLN03142
    Location:7501232
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    COG1196
    Location:370570
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam09606
    Location:42217
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18062
    Location:731981
    DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
    pfam07529
    Location:461531
    HSA
    pfam08880
    Location:171205
    QLQ
    pfam14619
    Location:12911356
    SnAC; Snf2-ATP coupling, chromatin remodelling complex
  2. NM_001174079.1NP_001167550.1  transcription activator BRG1 isoform 3

    See identical proteins and their annotated locations for NP_001167550.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon and uses an alternate in-frame splice junction compared to variant 4. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 4.
    Source sequence(s)
    AK160825, AK166837, BC079560
    Consensus CDS
    CCDS57662.1
    UniProtKB/Swiss-Prot
    Q3TKT4, Q6AXG8
    UniProtKB/TrEMBL
    A0A6P5QC95
    Related
    ENSMUSP00000133922.2, ENSMUST00000174008.8
    Conserved Domains (9) summary
    cd05516
    Location:14251530
    Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
    smart00592
    Location:612656
    BRK; domain in transcription and CHROMO domain helicases
    PLN03142
    Location:7501232
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    COG1196
    Location:370570
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam09606
    Location:42217
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18062
    Location:731981
    DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
    pfam07529
    Location:461531
    HSA
    pfam08880
    Location:171205
    QLQ
    pfam14619
    Location:12911356
    SnAC; Snf2-ATP coupling, chromatin remodelling complex
  3. NM_001357764.1NP_001344693.1  transcription activator BRG1 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (4).
    Source sequence(s)
    AC161371
    UniProtKB/TrEMBL
    A0A6P5QDZ4
    Conserved Domains (9) summary
    cd05516
    Location:14581564
    Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
    smart00592
    Location:612656
    BRK; domain in transcription and CHROMO domain helicases
    PLN03142
    Location:7501232
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    COG1196
    Location:370570
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam09606
    Location:42217
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18062
    Location:731981
    DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
    pfam07529
    Location:461531
    HSA
    pfam08880
    Location:171205
    QLQ
    pfam14619
    Location:13241389
    SnAC; Snf2-ATP coupling, chromatin remodelling complex
  4. NM_011417.3NP_035547.2  transcription activator BRG1 isoform 2

    See identical proteins and their annotated locations for NP_035547.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 4. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 4..
    Source sequence(s)
    AK160825, BC079560
    Consensus CDS
    CCDS22909.1
    UniProtKB/Swiss-Prot
    Q3TKT4
    UniProtKB/TrEMBL
    A0A6P5QIE8
    Related
    ENSMUSP00000034707.9, ENSMUST00000034707.15
    Conserved Domains (9) summary
    cd05516
    Location:14251531
    Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
    smart00592
    Location:612656
    BRK; domain in transcription and CHROMO domain helicases
    PLN03142
    Location:7501232
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    COG1196
    Location:370570
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam09606
    Location:42217
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18062
    Location:731981
    DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
    pfam07529
    Location:461531
    HSA
    pfam08880
    Location:171205
    QLQ
    pfam14619
    Location:12911356
    SnAC; Snf2-ATP coupling, chromatin remodelling complex

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    21527377..21615526
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242438.3XP_011240740.1  transcription activator BRG1 isoform X1

    See identical proteins and their annotated locations for XP_011240740.1

    UniProtKB/TrEMBL
    A0A6P7R8Y5
    Conserved Domains (9) summary
    cd05516
    Location:14611567
    Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
    smart00592
    Location:612656
    BRK; domain in transcription and CHROMO domain helicases
    PLN03142
    Location:7501232
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    COG1196
    Location:370570
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam09606
    Location:42217
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18062
    Location:731981
    DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
    pfam07529
    Location:461531
    HSA
    pfam08880
    Location:171205
    QLQ
    pfam14619
    Location:13241389
    SnAC; Snf2-ATP coupling, chromatin remodelling complex
  2. XM_011242434.1XP_011240736.1  transcription activator BRG1 isoform X1

    See identical proteins and their annotated locations for XP_011240736.1

    UniProtKB/TrEMBL
    A0A6P7R8Y5
    Conserved Domains (9) summary
    cd05516
    Location:14611567
    Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
    smart00592
    Location:612656
    BRK; domain in transcription and CHROMO domain helicases
    PLN03142
    Location:7501232
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    COG1196
    Location:370570
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam09606
    Location:42217
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18062
    Location:731981
    DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
    pfam07529
    Location:461531
    HSA
    pfam08880
    Location:171205
    QLQ
    pfam14619
    Location:13241389
    SnAC; Snf2-ATP coupling, chromatin remodelling complex
  3. XM_011242435.1XP_011240737.1  transcription activator BRG1 isoform X2

    UniProtKB/TrEMBL
    A0A6P7R7G1
    Conserved Domains (9) summary
    cd05516
    Location:14611566
    Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
    smart00592
    Location:612656
    BRK; domain in transcription and CHROMO domain helicases
    PLN03142
    Location:7501232
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    COG1196
    Location:370570
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam09606
    Location:42217
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18062
    Location:731981
    DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
    pfam07529
    Location:461531
    HSA
    pfam08880
    Location:171205
    QLQ
    pfam14619
    Location:13241389
    SnAC; Snf2-ATP coupling, chromatin remodelling complex
  4. XM_006510122.2XP_006510185.2  transcription activator BRG1 isoform X3

    See identical proteins and their annotated locations for XP_006510185.2

    UniProtKB/TrEMBL
    A0A6P5QDZ4
    Conserved Domains (9) summary
    cd05516
    Location:14581564
    Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
    smart00592
    Location:612656
    BRK; domain in transcription and CHROMO domain helicases
    PLN03142
    Location:7501232
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    COG1196
    Location:370570
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam09606
    Location:42217
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18062
    Location:731981
    DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
    pfam07529
    Location:461531
    HSA
    pfam08880
    Location:171205
    QLQ
    pfam14619
    Location:13241389
    SnAC; Snf2-ATP coupling, chromatin remodelling complex
  5. XM_011242436.1XP_011240738.1  transcription activator BRG1 isoform X4

    Conserved Domains (9) summary
    cd05516
    Location:14581563
    Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
    smart00592
    Location:612656
    BRK; domain in transcription and CHROMO domain helicases
    PLN03142
    Location:7501232
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    COG1196
    Location:370570
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam09606
    Location:42217
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18062
    Location:731981
    DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
    pfam07529
    Location:461531
    HSA
    pfam08880
    Location:171205
    QLQ
    pfam14619
    Location:13241389
    SnAC; Snf2-ATP coupling, chromatin remodelling complex
  6. XM_006510117.2XP_006510180.2  transcription activator BRG1 isoform X6

    See identical proteins and their annotated locations for XP_006510180.2

    UniProtKB/Swiss-Prot
    Q3TKT4
    UniProtKB/TrEMBL
    A0A0R4J170, A0A6P5Q5T1
    Conserved Domains (9) summary
    cd05516
    Location:14281534
    Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
    smart00592
    Location:612656
    BRK; domain in transcription and CHROMO domain helicases
    PLN03142
    Location:7501232
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    COG1196
    Location:370570
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam09606
    Location:42217
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18062
    Location:731981
    DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
    pfam07529
    Location:461531
    HSA
    pfam08880
    Location:171205
    QLQ
    pfam14619
    Location:12911356
    SnAC; Snf2-ATP coupling, chromatin remodelling complex
  7. XM_006510119.2XP_006510182.2  transcription activator BRG1 isoform X7

    See identical proteins and their annotated locations for XP_006510182.2

    UniProtKB/Swiss-Prot
    Q3TKT4
    UniProtKB/TrEMBL
    A0A6P5QIE8
    Conserved Domains (9) summary
    cd05516
    Location:14251531
    Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
    smart00592
    Location:612656
    BRK; domain in transcription and CHROMO domain helicases
    PLN03142
    Location:7501232
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    COG1196
    Location:370570
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam09606
    Location:42217
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18062
    Location:731981
    DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
    pfam07529
    Location:461531
    HSA
    pfam08880
    Location:171205
    QLQ
    pfam14619
    Location:12911356
    SnAC; Snf2-ATP coupling, chromatin remodelling complex
  8. XM_006510120.2XP_006510183.2  transcription activator BRG1 isoform X8

    See identical proteins and their annotated locations for XP_006510183.2

    UniProtKB/Swiss-Prot
    Q3TKT4, Q6AXG8
    UniProtKB/TrEMBL
    A0A6P5QC95
    Conserved Domains (9) summary
    cd05516
    Location:14251530
    Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
    smart00592
    Location:612656
    BRK; domain in transcription and CHROMO domain helicases
    PLN03142
    Location:7501232
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    COG1196
    Location:370570
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam09606
    Location:42217
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18062
    Location:731981
    DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
    pfam07529
    Location:461531
    HSA
    pfam08880
    Location:171205
    QLQ
    pfam14619
    Location:12911356
    SnAC; Snf2-ATP coupling, chromatin remodelling complex
  9. XM_011242437.4XP_011240739.1  transcription activator BRG1 isoform X5

    Conserved Domains (9) summary
    cd05516
    Location:14811587
    Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
    smart00592
    Location:632676
    BRK; domain in transcription and CHROMO domain helicases
    PLN03142
    Location:7701252
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    COG1196
    Location:390590
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam09606
    Location:62237
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18062
    Location:7511001
    DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
    pfam07529
    Location:481551
    HSA
    pfam08880
    Location:191225
    QLQ
    pfam14619
    Location:13441409
    SnAC; Snf2-ATP coupling, chromatin remodelling complex
  10. XM_030244151.1XP_030100011.1  transcription activator BRG1 isoform X9

    Conserved Domains (4) summary
    cd05516
    Location:713819
    Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
    PLN03142
    Location:2484
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    cd17996
    Location:3233
    DEXHc_SMARCA2_SMARCA4; DEXH-box helicase domain of SMARCA2 and SMARCA4
    pfam14619
    Location:576641
    SnAC; Snf2-ATP coupling, chromatin remodelling complex