Format

Send to:

Choose Destination

SLC16A1 solute carrier family 16 member 1 [ Homo sapiens (human) ]

Gene ID: 6566, updated on 3-Sep-2017
Official Symbol
SLC16A1provided by HGNC
Official Full Name
solute carrier family 16 member 1provided by HGNC
Primary source
HGNC:HGNC:10922
See related
Ensembl:ENSG00000155380 MIM:600682; Vega:OTTHUMG00000012129
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MCT; HHF7; MCT1; MCT1D
Summary
The protein encoded by this gene is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane. Mutations in this gene are associated with erythrocyte lactate transporter defect. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2009]
Orthologs
Location:
1p13.2
Exon count:
7
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 1 NC_000001.11 (112911847..112956353, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (113454469..113498975, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378911 Neighboring gene uncharacterized HP08777 Neighboring gene ribosomal protein L39 pseudogene 8 Neighboring gene aldo-keto reductase family 7 member A2 pseudogene 1 Neighboring gene SLC16A1 antisense RNA 1 Neighboring gene uncharacterized LOC107985189

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ36745, MGC44475

Gene Ontology Provided by GOA

Function Evidence Code Pubs
lactate transmembrane transporter activity EXP
Inferred from Experiment
more info
PubMed 
mevalonate transmembrane transporter activity TAS
Traceable Author Statement
more info
PubMed 
monocarboxylic acid transmembrane transporter activity TAS
Traceable Author Statement
more info
 
organic cyclic compound binding IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
symporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
behavioral response to nutrient IEA
Inferred from Electronic Annotation
more info
 
cellular response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
 
centrosome cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 
leukocyte migration TAS
Traceable Author Statement
more info
 
lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
mevalonate transport TAS
Traceable Author Statement
more info
PubMed 
monocarboxylic acid transport TAS
Traceable Author Statement
more info
PubMed 
plasma membrane lactate transport ISS
Inferred from Sequence or Structural Similarity
more info
 
pyruvate metabolic process TAS
Traceable Author Statement
more info
 
regulation of insulin secretion IEA
Inferred from Electronic Annotation
more info
 
response to food IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell junction IDA
Inferred from Direct Assay
more info
 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
monocarboxylate transporter 1
Names
MCT 1
solute carrier family 16 (monocarboxylate transporter), member 1
solute carrier family 16 (monocarboxylic acid transporters), member 1
solute carrier family 16, member 1 (monocarboxylic acid transporter 1)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_015880.2 RefSeqGene

    Range
    4576..49082
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001166496.1NP_001159968.1  monocarboxylate transporter 1

    See identical proteins and their annotated locations for NP_001159968.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AI656300, AK094064, AK296688, AL162079, BC026317, BP294493
    Consensus CDS
    CCDS858.1
    UniProtKB/Swiss-Prot
    P53985
    UniProtKB/TrEMBL
    A0A024R0H1, B4DKS0
    Related
    ENSP00000441065.1, ENST00000538576.5
    Conserved Domains (2) summary
    cd06174
    Location:20439
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00892
    Location:1455
    2A0113; monocarboxylate transporter 1
  2. NM_003051.3NP_003042.3  monocarboxylate transporter 1

    See identical proteins and their annotated locations for NP_003042.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AJ438943, AL162079, BC026317, BM712667, DB443025
    Consensus CDS
    CCDS858.1
    UniProtKB/Swiss-Prot
    P53985
    UniProtKB/TrEMBL
    A0A024R0H1
    Related
    ENSP00000358640.3, OTTHUMP00000013960, ENST00000369626.7, OTTHUMT00000033539
    Conserved Domains (2) summary
    cd06174
    Location:20439
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00892
    Location:1455
    2A0113; monocarboxylate transporter 1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p7 Primary Assembly

    Range
    112911847..112956353 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011542026.2XP_011540328.1  monocarboxylate transporter 1 isoform X1

    See identical proteins and their annotated locations for XP_011540328.1

    UniProtKB/Swiss-Prot
    P53985
    UniProtKB/TrEMBL
    A0A024R0H1
    Conserved Domains (2) summary
    cd06174
    Location:20439
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00892
    Location:1455
    2A0113; monocarboxylate transporter 1
  2. XM_011542027.2XP_011540329.1  monocarboxylate transporter 1 isoform X1

    See identical proteins and their annotated locations for XP_011540329.1

    UniProtKB/Swiss-Prot
    P53985
    UniProtKB/TrEMBL
    A0A024R0H1
    Conserved Domains (2) summary
    cd06174
    Location:20439
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00892
    Location:1455
    2A0113; monocarboxylate transporter 1

Reference GRCh38.p7 PATCHES

Genomic

  1. NW_009646196.1 Reference GRCh38.p7 PATCHES

    Range
    2426..46932 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 Alternate CHM1_1.1

    Range
    113569526..113614046 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center