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SLC16A1 solute carrier family 16 member 1 [ Homo sapiens (human) ]

Gene ID: 6566, updated on 2-Aug-2020

Summary

Official Symbol
SLC16A1provided by HGNC
Official Full Name
solute carrier family 16 member 1provided by HGNC
Primary source
HGNC:HGNC:10922
See related
Ensembl:ENSG00000155380 MIM:600682
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MCT; HHF7; MCT1; MCT1D
Summary
The protein encoded by this gene is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane. Mutations in this gene are associated with erythrocyte lactate transporter defect. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2009]
Expression
Broad expression in heart (RPKM 23.3), colon (RPKM 22.1) and 23 other tissues See more
Orthologs

Genomic context

See SLC16A1 in Genome Data Viewer
Location:
1p13.2
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (112911847..112956196, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (113454469..113498975, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L39 pseudogene 8 Neighboring gene Sharpr-MPRA regulatory region 4510 Neighboring gene AKR7A2 pseudogene 1 Neighboring gene SLC16A1 antisense RNA 1 Neighboring gene uncharacterized LOC107985189

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ36745, MGC44475

Gene Ontology Provided by GOA

Function Evidence Code Pubs
carboxylic acid transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
lactate transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
lactate transmembrane transporter activity TAS
Traceable Author Statement
more info
PubMed 
mevalonate transmembrane transporter activity TAS
Traceable Author Statement
more info
PubMed 
monocarboxylic acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
monocarboxylic acid transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
monocarboxylic acid transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
organic cyclic compound binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
symporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
behavioral response to nutrient IEA
Inferred from Electronic Annotation
more info
 
carboxylic acid transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
 
centrosome cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 
leukocyte migration TAS
Traceable Author Statement
more info
 
lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
mevalonate transport TAS
Traceable Author Statement
more info
PubMed 
monocarboxylic acid transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
monocarboxylic acid transport IDA
Inferred from Direct Assay
more info
PubMed 
monocarboxylic acid transport ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane lactate transport ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane lactate transport TAS
Traceable Author Statement
more info
PubMed 
pyruvate metabolic process TAS
Traceable Author Statement
more info
 
regulation of insulin secretion IEA
Inferred from Electronic Annotation
more info
 
response to food IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
apical plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
basal plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
basolateral plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cell junction IDA
Inferred from Direct Assay
more info
 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
lateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
monocarboxylate transporter 1
Names
MCT 1
solute carrier family 16 (monocarboxylate transporter), member 1
solute carrier family 16 (monocarboxylic acid transporters), member 1
solute carrier family 16, member 1 (monocarboxylic acid transporter 1)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_015880.2 RefSeqGene

    Range
    4576..49082
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001166496.1NP_001159968.1  monocarboxylate transporter 1

    See identical proteins and their annotated locations for NP_001159968.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AI656300, AK094064, AK296688, AL162079, BC026317, BP294493
    Consensus CDS
    CCDS858.1
    UniProtKB/Swiss-Prot
    P53985
    UniProtKB/TrEMBL
    A0A024R0H1, B4DKS0
    Related
    ENSP00000441065.1, ENST00000538576.5
    Conserved Domains (2) summary
    cd06174
    Location:20439
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00892
    Location:1455
    2A0113; monocarboxylate transporter 1
  2. NM_003051.4NP_003042.3  monocarboxylate transporter 1

    See identical proteins and their annotated locations for NP_003042.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL158844
    Consensus CDS
    CCDS858.1
    UniProtKB/Swiss-Prot
    P53985
    UniProtKB/TrEMBL
    A0A024R0H1
    Related
    ENSP00000358640.3, ENST00000369626.7
    Conserved Domains (2) summary
    cd06174
    Location:20439
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00892
    Location:1455
    2A0113; monocarboxylate transporter 1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    112911847..112956196 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_009646196.1 Reference GRCh38.p13 PATCHES

    Range
    2426..46775 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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