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SLC9A5 solute carrier family 9 member A5 [ Homo sapiens (human) ]

Gene ID: 6553, updated on 8-Jul-2021

Summary

Official Symbol
SLC9A5provided by HGNC
Official Full Name
solute carrier family 9 member A5provided by HGNC
Primary source
HGNC:HGNC:11078
See related
Ensembl:ENSG00000135740 MIM:600477
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NHE5
Expression
Biased expression in spleen (RPKM 6.3), testis (RPKM 2.2) and 7 other tissues See more
Orthologs
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Genomic context

See SLC9A5 in Genome Data Viewer
Location:
16q22.1
Exon count:
17
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (67247549..67272191)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (67282882..67306094)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene transmembrane protein 208 Neighboring gene formin homology 2 domain containing 1 Neighboring gene pleckstrin homology and RhoGEF domain containing G4 Neighboring gene potassium channel tetramerization domain containing 19 Neighboring gene RN7SK pseudogene 118

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef EIPA, a potent and specific inhibitor of Na+/H+ exchanger activity, significantly inhibits the Nef internalization into M2-macrophages, indicating that Nef is imported by Na+/H+ exchanger (solute carrier family 9, subfamily A) PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables potassium:proton antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables sodium:proton antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables sodium:proton antiporter activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
involved_in anion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in ion transport TAS
Traceable Author Statement
more info
 
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of intracellular pH IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in sodium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
sodium/hydrogen exchanger 5
Names
NHE-5
Na(+)/H(+) exchanger 5
solute carrier family 9 (sodium/hydrogen exchanger), member 5
solute carrier family 9 member 5
solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001323971.2NP_001310900.1  sodium/hydrogen exchanger 5 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC040160
    Conserved Domains (1) summary
    TIGR00840
    Location:41573
    b_cpa1; sodium/hydrogen exchanger 3
  2. NM_001323972.2NP_001310901.1  sodium/hydrogen exchanger 5 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC040160
  3. NM_001323973.2NP_001310902.1  sodium/hydrogen exchanger 5 isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC040160
    Conserved Domains (2) summary
    TIGR00840
    Location:41630
    b_cpa1; sodium/hydrogen exchanger 3
    pfam00999
    Location:50455
    Na_H_Exchanger; Sodium/hydrogen exchanger family
  4. NM_001323974.2NP_001310903.1  sodium/hydrogen exchanger 5 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC040160
  5. NM_001323975.2NP_001310904.1  sodium/hydrogen exchanger 5 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC040160
    Conserved Domains (2) summary
    TIGR00840
    Location:1335
    b_cpa1; sodium/hydrogen exchanger 3
    cl01133
    Location:1160
    Na_H_Exchanger; Sodium/hydrogen exchanger family
  6. NM_004594.3NP_004585.1  sodium/hydrogen exchanger 5 isoform 1 precursor

    See identical proteins and their annotated locations for NP_004585.1

    Status: VALIDATED

    Source sequence(s)
    AF111173, AL137689, DB475730
    Consensus CDS
    CCDS42178.1
    UniProtKB/Swiss-Prot
    Q14940
    UniProtKB/TrEMBL
    Q9NSW9
    Related
    ENSP00000299798.11, ENST00000299798.16
    Conserved Domains (1) summary
    cl25615
    Location:41630
    NhaP2; NhaP-type Na+/H+ and K+/H+ antiporter with C-terminal TrkAC and CorC domains [Energy production and conversion, Inorganic ion transport and metabolism]

RNA

  1. NR_136664.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC040160
  2. NR_136665.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC040160
    Related
    ENST00000564812.5
  3. NR_136666.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC040160
  4. NR_136667.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC040160

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    67247549..67272191
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017023594.1XP_016879083.1  sodium/hydrogen exchanger 5 isoform X1

RNA

  1. XR_001751969.1 RNA Sequence

  2. XR_001751967.2 RNA Sequence

  3. XR_001751968.1 RNA Sequence

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