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ZNF574 zinc finger protein 574 [ Homo sapiens (human) ]

Gene ID: 64763, updated on 8-Dec-2022

Summary

Official Symbol
ZNF574provided by HGNC
Official Full Name
zinc finger protein 574provided by HGNC
Primary source
HGNC:HGNC:26166
See related
Ensembl:ENSG00000105732 AllianceGenome:HGNC:26166
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FP972
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 9.8), ovary (RPKM 4.8) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF574 in Genome Data Viewer
Location:
19q13.2
Exon count:
7
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (42068477..42081552)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (44887841..44900921)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (42572629..42585704)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATPase Na+/K+ transporting subunit alpha 3 Neighboring gene glutamate ionotropic receptor kainate type subunit 5 Neighboring gene Sharpr-MPRA regulatory regions 411/7488 and 4104 Neighboring gene POU class 2 homeobox 2 Neighboring gene POU2F2 antisense RNA 1 Neighboring gene microRNA 4323 Neighboring gene death effector domain containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22059

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330519.2NP_001317448.1  zinc finger protein 574 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AF447880, AK131369
    Consensus CDS
    CCDS82356.1
    UniProtKB/Swiss-Prot
    Q6ZN55
    UniProtKB/TrEMBL
    A0A0C4DFM2, Q71MF7
    Related
    ENSP00000222339.6, ENST00000222339.7
  2. NM_022752.6NP_073589.4  zinc finger protein 574 isoform 1

    See identical proteins and their annotated locations for NP_073589.4

    Status: VALIDATED

    Source sequence(s)
    AF447880, BC001184, DA404303
    Consensus CDS
    CCDS12596.1
    UniProtKB/Swiss-Prot
    Q6ZN55, Q9H6N0
    UniProtKB/TrEMBL
    Q71MF7
    Related
    ENSP00000351939.3, ENST00000359044.5
    Conserved Domains (4) summary
    cd11674
    Location:437491
    lambda-1; inner capsid protein lambda-1 or VP3
    COG5048
    Location:495848
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:497517
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam15909
    Location:311390
    zf-C2H2_8; C2H2-type zinc ribbon

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    42068477..42081552
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527228.4XP_011525530.1  zinc finger protein 574 isoform X1

    See identical proteins and their annotated locations for XP_011525530.1

    UniProtKB/Swiss-Prot
    Q6ZN55, Q9H6N0
    Conserved Domains (4) summary
    cd11674
    Location:437491
    lambda-1; inner capsid protein lambda-1 or VP3
    COG5048
    Location:495848
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:497517
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam15909
    Location:311390
    zf-C2H2_8; C2H2-type zinc ribbon
  2. XM_011527230.4XP_011525532.1  zinc finger protein 574 isoform X1

    See identical proteins and their annotated locations for XP_011525532.1

    UniProtKB/Swiss-Prot
    Q6ZN55, Q9H6N0
    Related
    ENSP00000469029.1, ENST00000600245.1
    Conserved Domains (4) summary
    cd11674
    Location:437491
    lambda-1; inner capsid protein lambda-1 or VP3
    COG5048
    Location:495848
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:497517
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam15909
    Location:311390
    zf-C2H2_8; C2H2-type zinc ribbon
  3. XM_011527229.4XP_011525531.1  zinc finger protein 574 isoform X1

    See identical proteins and their annotated locations for XP_011525531.1

    UniProtKB/Swiss-Prot
    Q6ZN55, Q9H6N0
    Conserved Domains (4) summary
    cd11674
    Location:437491
    lambda-1; inner capsid protein lambda-1 or VP3
    COG5048
    Location:495848
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:497517
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam15909
    Location:311390
    zf-C2H2_8; C2H2-type zinc ribbon
  4. XM_005259159.4XP_005259216.1  zinc finger protein 574 isoform X1

    See identical proteins and their annotated locations for XP_005259216.1

    UniProtKB/Swiss-Prot
    Q6ZN55, Q9H6N0
    Conserved Domains (4) summary
    cd11674
    Location:437491
    lambda-1; inner capsid protein lambda-1 or VP3
    COG5048
    Location:495848
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:497517
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam15909
    Location:311390
    zf-C2H2_8; C2H2-type zinc ribbon

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    44887841..44900921
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)