U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Sp5 trans-acting transcription factor 5 [ Mus musculus (house mouse) ]

Gene ID: 64406, updated on 12-May-2024

Summary

Official Symbol
Sp5provided by MGI
Official Full Name
trans-acting transcription factor 5provided by MGI
Primary source
MGI:MGI:1927715
See related
Ensembl:ENSMUSG00000075304 AllianceGenome:MGI:1927715
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within bone morphogenesis; cellular response to organic cyclic compound; and post-anal tail morphogenesis. Predicted to be located in nucleus. Is expressed in several structures, including alimentary system; brain; branchial arch; embryo ectoderm; and embryo mesenchyme. Orthologous to human SP5 (Sp5 transcription factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in duodenum adult (RPKM 49.5), small intestine adult (RPKM 18.4) and 9 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Location:
2 C2; 2 41.49 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (70305267..70308070)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (70474923..70477726)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4463 Neighboring gene myosin IIIB Neighboring gene STARR-seq mESC enhancer starr_04751 Neighboring gene STARR-seq mESC enhancer starr_04752 Neighboring gene STARR-seq mESC enhancer starr_04756 Neighboring gene STARR-seq mESC enhancer starr_04757 Neighboring gene STARR-seq mESC enhancer starr_04758 Neighboring gene STARR-seq mESC enhancer starr_04760 Neighboring gene STARR-seq mESC enhancer starr_04762 Neighboring gene ribosomal protein L9, pseudogene 7 Neighboring gene glutamate decarboxylase 1, opposite strand Neighboring gene glutamate rich 2 Neighboring gene STARR-seq mESC enhancer starr_04764 Neighboring gene glutamate decarboxylase 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (3)  1 citation

General gene information

Markers

Clone Names

  • MGC144801, MGC144802

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022435.2NP_071880.1  transcription factor Sp5

    See identical proteins and their annotated locations for NP_071880.1

    Status: PROVISIONAL

    Source sequence(s)
    AK036234
    Consensus CDS
    CCDS16106.1
    UniProtKB/Swiss-Prot
    Q149T2, Q9JHX2
    Related
    ENSMUSP00000097620.3, ENSMUST00000100043.3
    Conserved Domains (5) summary
    COG5048
    Location:311384
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:301320
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:342365
    zf-H2C2_2; Zinc-finger double domain
    cd22541
    Location:106297
    SP5_N; N-terminal domain of transcription factor Specificity Protein (SP) 5
    cl41773
    Location:3147
    SP1-4_N; N-terminal domain of transcription factor Specificity Proteins (SP) 1-4

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    70305267..70308070
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)