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SP5 Sp5 transcription factor [ Homo sapiens (human) ]

Gene ID: 389058, updated on 19-Aug-2025
Official Symbol
SP5provided by HGNC
Official Full Name
Sp5 transcription factorprovided by HGNC
Primary source
HGNC:HGNC:14529
See related
Ensembl:ENSG00000204335 MIM:609391; AllianceGenome:HGNC:14529
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within bone morphogenesis and post-anal tail morphogenesis. Predicted to be located in chromatin. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Broad expression in endometrium (RPKM 1.5), prostate (RPKM 0.9) and 16 other tissues See more
Orthologs
mouse all
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See SP5 in Genome Data Viewer
Location:
2q31.1
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (170715337..170718078)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (171192053..171195210)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (171571847..171574588)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene myosin IIIB Neighboring gene uncharacterized LOC100130256 Neighboring gene NANOG hESC enhancer GRCh37_chr2:171508220-171508765 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:171536815-171537364 Neighboring gene MPRA-validated peak3923 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:171538465-171539014 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:171571431-171572220 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12090 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:171572221-171573008 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:171573009-171573798 Neighboring gene ERICH2 divergent transcript Neighboring gene long intergenic non-protein coding RNA 1124 Neighboring gene Sharpr-MPRA regulatory region 1892 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12091 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12092 Neighboring gene eukaryotic translation initiation factor 2 subunit 2 beta pseudogene 4 Neighboring gene glutamate rich 2

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Elevated expression and potential roles of human Sp5, a member of Sp transcription factor family, in human cancers. Chen Y, et al. Biochem Biophys Res Commun, 2006 Feb 17. PMID 16380080
  2. Circular RNA circSP5 promotes liver metastasis of colorectal cancer via SP5-mediated BAMBI transcription. Zhi Y, et al. Funct Integr Genomics, 2023 Aug 18. PMID 37596430
  3. The WNT target SP5 negatively regulates WNT transcriptional programs in human pluripotent stem cells. Huggins IJ, et al. Nat Commun, 2017 Oct 18. PMID 29044119, Free PMC Article
  4. CPT1A mediates the succinylation of SP5 which activates transcription of PDPK1 to promote the viability and glycolysis of prostate cancer cells. Liu S, et al. Cancer Biol Ther, 2024 Dec 31. PMID 38494680, Free PMC Article
  5. Nkx3.1 binds and negatively regulates the transcriptional activity of Sp-family members in prostate-derived cells. Simmons SO, et al. Biochem J, 2006 Jan 1. PMID 16201967, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CPT1A mediates the succinylation of SP5 which activates transcription of PDPK1 to promote the viability and glycolysis of prostate cancer cells.
    Title: CPT1A mediates the succinylation of SP5 which activates transcription of PDPK1 to promote the viability and glycolysis of prostate cancer cells.
  2. Circular RNA circSP5 promotes liver metastasis of colorectal cancer via SP5-mediated BAMBI transcription.
    Title: Circular RNA circSP5 promotes liver metastasis of colorectal cancer via SP5-mediated BAMBI transcription.
  3. SP5 negatively regulates WNT3a transcriptional programs in human pluripotent stem cells.
    Title: The WNT target SP5 negatively regulates WNT transcriptional programs in human pluripotent stem cells.
  4. human Sp5 is a member of Sp transcription factor family with a role in human cancers
    Title: Elevated expression and potential roles of human Sp5, a member of Sp transcription factor family, in human cancers.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within bone morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within post-anal tail morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
transcription factor Sp5

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003845.3 → NP_001003845.1  transcription factor Sp5

    See identical proteins and their annotated locations for NP_001003845.1

    Status: VALIDATED

    Source sequence(s)
    AB096175, AC007405, AW450640, BQ064677, CN275885
    Consensus CDS
    CCDS33322.1
    UniProtKB/Swiss-Prot
    Q6BEB4
    Related
    ENSP00000364430.3, ENST00000375281.4
    Conserved Domains (4) summary
    COG5048
    Location:311 → 384
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:301 → 320
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:356 → 378
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:342 → 365
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    170715337..170718078
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005246542.5 → XP_005246599.1  transcription factor Sp5 isoform X1

    Conserved Domains (4) summary
    COG5048
    Location:355 → 428
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:345 → 364
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:400 → 422
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:386 → 409
    zf-H2C2_2; Zinc-finger double domain

  2. XM_047444264.1 → XP_047300220.1  transcription factor Sp5 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    171192053..171195210
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054341964.1 → XP_054197939.1  transcription factor Sp5 isoform X1

  2. XM_054341965.1 → XP_054197940.1  transcription factor Sp5 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6BEB4.1 GenPept UniProtKB/Swiss-Prot:Q6BEB4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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