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SP5 Sp5 transcription factor [ Homo sapiens (human) ]

Gene ID: 389058, updated on 23-Mar-2024

Summary

Official Symbol
SP5provided by HGNC
Official Full Name
Sp5 transcription factorprovided by HGNC
Primary source
HGNC:HGNC:14529
See related
Ensembl:ENSG00000204335 MIM:609391; AllianceGenome:HGNC:14529
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within bone morphogenesis; cellular response to organic cyclic compound; and post-anal tail morphogenesis. Predicted to be located in nucleus. Predicted to be part of chromatin. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in endometrium (RPKM 1.5), prostate (RPKM 0.9) and 16 other tissues See more
Orthologs
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Genomic context

Location:
2q31.1
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (170715337..170718078)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (171192053..171195210)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (171571847..171574588)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene myosin IIIB Neighboring gene uncharacterized LOC100130256 Neighboring gene NANOG hESC enhancer GRCh37_chr2:171508220-171508765 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:171536815-171537364 Neighboring gene MPRA-validated peak3923 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:171538465-171539014 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:171571431-171572220 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12090 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:171572221-171573008 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:171573009-171573798 Neighboring gene ERICH2 divergent transcript Neighboring gene long intergenic non-protein coding RNA 1124 Neighboring gene Sharpr-MPRA regulatory region 1892 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12091 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12092 Neighboring gene eukaryotic translation initiation factor 2 subunit 2 beta pseudogene 4 Neighboring gene glutamate rich 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003845.3NP_001003845.1  transcription factor Sp5

    See identical proteins and their annotated locations for NP_001003845.1

    Status: VALIDATED

    Source sequence(s)
    AB096175, AC007405, AW450640, BQ064677, CN275885
    Consensus CDS
    CCDS33322.1
    UniProtKB/Swiss-Prot
    Q6BEB4
    Related
    ENSP00000364430.3, ENST00000375281.4
    Conserved Domains (4) summary
    COG5048
    Location:311384
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:301320
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:356378
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:342365
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    170715337..170718078
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005246542.5XP_005246599.1  transcription factor Sp5 isoform X1

    Conserved Domains (4) summary
    COG5048
    Location:355428
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:345364
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:400422
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:386409
    zf-H2C2_2; Zinc-finger double domain
  2. XM_047444264.1XP_047300220.1  transcription factor Sp5 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    171192053..171195210
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054341964.1XP_054197939.1  transcription factor Sp5 isoform X1

  2. XM_054341965.1XP_054197940.1  transcription factor Sp5 isoform X2