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SP5 Sp5 transcription factor [ Homo sapiens (human) ]

Gene ID: 389058, updated on 1-Jun-2020

Summary

Official Symbol
SP5provided by HGNC
Official Full Name
Sp5 transcription factorprovided by HGNC
Primary source
HGNC:HGNC:14529
See related
Ensembl:ENSG00000204335 MIM:609391
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in endometrium (RPKM 1.5), prostate (RPKM 0.9) and 16 other tissues See more
Orthologs

Genomic context

See SP5 in Genome Data Viewer
Location:
2q31.1
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (170714725..170718078)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (171571857..171574498)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene myosin IIIB Neighboring gene uncharacterized LOC100130256 Neighboring gene uncharacterized LOC101926913 Neighboring gene long intergenic non-protein coding RNA 1124 Neighboring gene eukaryotic translation initiation factor 2 subunit 2 beta pseudogene 4 Neighboring gene glutamate rich 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
bone morphogenesis IEA
Inferred from Electronic Annotation
more info
 
cellular response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
post-anal tail morphogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003845.3NP_001003845.1  transcription factor Sp5

    See identical proteins and their annotated locations for NP_001003845.1

    Status: VALIDATED

    Source sequence(s)
    AB096175, AC007405, AW450640, BQ064677, CN275885
    Consensus CDS
    CCDS33322.1
    UniProtKB/Swiss-Prot
    Q6BEB4
    Related
    ENSP00000364430.3, ENST00000375281.4
    Conserved Domains (4) summary
    COG5048
    Location:311384
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:301320
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:356378
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:342365
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    170714725..170718078
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011511159.2XP_011509461.1  transcription factor Sp5 isoform X1

    Conserved Domains (4) summary
    COG5048
    Location:367440
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:357376
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:412434
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:398421
    zf-H2C2_2; Zinc-finger double domain
  2. XM_005246542.4XP_005246599.1  transcription factor Sp5 isoform X2

    Conserved Domains (4) summary
    COG5048
    Location:355428
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:345364
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:400422
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:386409
    zf-H2C2_2; Zinc-finger double domain
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