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ZMAT3 zinc finger matrin-type 3 [ Homo sapiens (human) ]

Gene ID: 64393, updated on 7-Jun-2020

Summary

Official Symbol
ZMAT3provided by HGNC
Official Full Name
zinc finger matrin-type 3provided by HGNC
Primary source
HGNC:HGNC:29983
See related
Ensembl:ENSG00000172667 MIM:606452
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WIG1; WIG-1; PAG608
Summary
This gene encodes a protein containing three zinc finger domains and a nuclear localization signal. The mRNA and the protein of this gene are upregulated by wildtype p53 and overexpression of this gene inhibits tumor cell growth, suggesting that this gene may have a role in the p53-dependent growth regulatory pathway. Alternative splicing of this gene results in two transcript variants encoding two isoforms differing in only one amino acid. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 11.2), gall bladder (RPKM 5.6) and 24 other tissues See more
Orthologs

Genomic context

See ZMAT3 in Genome Data Viewer
Location:
3q26.32
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (179017223..179072513, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (178735011..178790067, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase A pseudogene 75 Neighboring gene KCNMB2 antisense RNA 1 Neighboring gene potassium calcium-activated channel subfamily M regulatory beta subunit 2 Neighboring gene uncharacterized LOC101928739 Neighboring gene phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Neighboring gene potassium calcium-activated channel subfamily M regulatory beta subunit 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies new susceptibility loci for posttraumatic stress disorder.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12296, FLJ31683, MGC10613

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cellular response to DNA damage stimulus IEA
Inferred from Electronic Annotation
more info
 
positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
protein transport IEA
Inferred from Electronic Annotation
more info
 
regulation of growth IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleolus IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
zinc finger matrin-type protein 3
Names
WIG-1/PAG608 protein
p53 target zinc finger protein
p53-activated gene 608 protein
zinc finger protein WIG1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050678.1 RefSeqGene

    Range
    5471..60057
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001375824.1NP_001362753.1  zinc finger matrin-type protein 3 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC117456
  2. NM_001375825.1NP_001362754.1  zinc finger matrin-type protein 3 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC117456
  3. NM_001375826.1NP_001362755.1  zinc finger matrin-type protein 3 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC117456
  4. NM_001375827.1NP_001362756.1  zinc finger matrin-type protein 3 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC117456
  5. NM_001375828.1NP_001362757.1  zinc finger matrin-type protein 3 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC117456
  6. NM_001375829.1NP_001362758.1  zinc finger matrin-type protein 3 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC117456
  7. NM_022470.4NP_071915.1  zinc finger matrin-type protein 3 isoform 1

    See identical proteins and their annotated locations for NP_071915.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks an alternate exon in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The resulting isoform (1) includes one extra residue in the C-terminal region, compared to isoform 2.
    Source sequence(s)
    AC117456, BC002896, DA001239
    Consensus CDS
    CCDS3224.1
    UniProtKB/Swiss-Prot
    Q9HA38
    Related
    ENSP00000311221.2, ENST00000311417.7
    Conserved Domains (2) summary
    smart00451
    Location:67101
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:7294
    ZF_C2H2; C2H2 Zn finger [structural motif]
  8. NM_152240.3NP_689426.1  zinc finger matrin-type protein 3 isoform 2

    See identical proteins and their annotated locations for NP_689426.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longer transcript and encodes the shorter isoform (2).
    Source sequence(s)
    AC117456, AK122768, BC002896, DA001239
    Consensus CDS
    CCDS46962.1
    UniProtKB/Swiss-Prot
    Q9HA38
    Related
    ENSP00000396506.1, ENST00000432729.5
    Conserved Domains (2) summary
    smart00451
    Location:67101
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:7294
    ZF_C2H2; C2H2 Zn finger [structural motif]

RNA

  1. NR_164720.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC117456
  2. NR_164721.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC117456

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    179017223..179072513 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011513073.2XP_011511375.1  zinc finger matrin-type protein 3 isoform X1

    See identical proteins and their annotated locations for XP_011511375.1

    UniProtKB/Swiss-Prot
    Q9HA38
    Conserved Domains (2) summary
    smart00451
    Location:67101
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:7294
    ZF_C2H2; C2H2 Zn finger [structural motif]
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