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SDHA succinate dehydrogenase complex flavoprotein subunit A [ Homo sapiens (human) ]

Gene ID: 6389, updated on 11-Sep-2019

Summary

Official Symbol
SDHAprovided by HGNC
Official Full Name
succinate dehydrogenase complex flavoprotein subunit Aprovided by HGNC
Primary source
HGNC:HGNC:10680
See related
Ensembl:ENSG00000073578 MIM:600857
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FP; PGL5; SDH1; SDH2; SDHF; CMD1GG
Summary
This gene encodes a major catalytic subunit of succinate-ubiquinone oxidoreductase, a complex of the mitochondrial respiratory chain. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. Mutations in this gene have been associated with a form of mitochondrial respiratory chain deficiency known as Leigh Syndrome. A pseudogene has been identified on chromosome 3q29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]
Expression
Ubiquitous expression in heart (RPKM 63.7), kidney (RPKM 34.3) and 24 other tissues See more
Orthologs

Genomic context

See SDHA in Genome Data Viewer
Location:
5p15.33
Exon count:
15
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (218223..264816)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (218338..256815)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 14B Neighboring gene coiled-coil domain containing 127 Neighboring gene heart tissue-associated transcript 5 Neighboring gene programmed cell death 6 Neighboring gene protein phosphatase 4 regulatory subunit 2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef HIV-1 Nef is identified to have a physical interaction with succinate dehydrogenase complex, subunit A, flavoprotein (SDHA) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of succinate dehydrogenase complex, subunit A (SDHA) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
electron transfer activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
succinate dehydrogenase (ubiquinone) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
succinate dehydrogenase (ubiquinone) activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
succinate dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to succinate dehydrogenase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
mitochondrial electron transport, succinate to ubiquinone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
oxidation-reduction process IDA
Inferred from Direct Assay
more info
PubMed 
respiratory electron transport chain IDA
Inferred from Direct Assay
more info
PubMed 
succinate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
tricarboxylic acid cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
 
tricarboxylic acid cycle TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) ISS
Inferred from Sequence or Structural Similarity
more info
 
mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) TAS
Traceable Author Statement
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 
plasma membrane succinate dehydrogenase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
Names
flavoprotein subunit of complex II
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
NP_001281261.1
NP_001317687.1
NP_004159.2
XP_011512374.1
XP_011512375.1
XP_016865174.1
XP_024301911.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012339.1 RefSeqGene

    Range
    5080..43842
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001294332.1NP_001281261.1  succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC021087, AK291311, AK295937, DA160919, HY265959
    Consensus CDS
    CCDS77992.1
    UniProtKB/Swiss-Prot
    P31040
    Related
    ENSP00000427703.1, ENST00000510361.5
    Conserved Domains (3) summary
    PTZ00139
    Location:40616
    PTZ00139; Succinate dehydrogenase [ubiquinone] flavoprotein subunit; Provisional
    pfam02910
    Location:467616
    Succ_DH_flav_C; Fumarate reductase flavoprotein C-term
    cl21454
    Location:104423
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  2. NM_001330758.1NP_001317687.1  succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two in-frame exons in the 3' coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AC021087
    Consensus CDS
    CCDS82985.1
    UniProtKB/TrEMBL
    D6RFM5
    Related
    ENSP00000426514.1, ENST00000504309.5
    Conserved Domains (3) summary
    PTZ00139
    Location:40583
    PTZ00139; Succinate dehydrogenase [ubiquinone] flavoprotein subunit; Provisional
    pfam02910
    Location:539583
    Succ_DH_flav_C; Fumarate reductase flavoprotein C-term
    cl21454
    Location:85471
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  3. NM_004168.4NP_004159.2  succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_004159.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC021087, AK291311, BC001380, DA160919, HY265959
    Consensus CDS
    CCDS3853.1
    UniProtKB/Swiss-Prot
    P31040
    UniProtKB/TrEMBL
    A0A024QZ30
    Related
    ENSP00000264932.6, ENST00000264932.11
    Conserved Domains (1) summary
    PTZ00139
    Location:40664
    PTZ00139; Succinate dehydrogenase [ubiquinone] flavoprotein subunit; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    218223..264816
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011514072.2XP_011512374.1  succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X3

    Conserved Domains (3) summary
    PTZ00139
    Location:40636
    PTZ00139; Succinate dehydrogenase [ubiquinone] flavoprotein subunit; Provisional
    pfam02910
    Location:515635
    Succ_DH_flav_C; Fumarate reductase flavoprotein C-term
    cl21454
    Location:85471
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  2. XM_011514073.2XP_011512375.1  succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X4

    Conserved Domains (2) summary
    TIGR01816
    Location:80555
    sdhA_forward; succinate dehydrogenase, flavoprotein subunit, E. coli/mitochondrial subgroup
    cl21454
    Location:85471
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  3. XM_017009685.2XP_016865174.1  succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1

  4. XM_024446143.1XP_024301911.1  succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X2

    Conserved Domains (1) summary
    cl27323
    Location:40592
    Succ_DH_flav_C; Fumarate reductase flavoprotein C-term

RNA

  1. XR_002956167.1 RNA Sequence

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