U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Sdha succinate dehydrogenase complex, subunit A, flavoprotein (Fp) [ Mus musculus (house mouse) ]

Gene ID: 66945, updated on 1-Mar-2024

Summary

Official Symbol
Sdhaprovided by MGI
Official Full Name
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)provided by MGI
Primary source
MGI:MGI:1914195
See related
Ensembl:ENSMUSG00000021577 AllianceGenome:MGI:1914195
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FP; SDH2; SDHF; 4921513A11; 1500032O14Rik; 2310034D06Rik
Summary
Predicted to enable electron transfer activity; flavin adenine dinucleotide binding activity; and succinate dehydrogenase (ubiquinone) activity. Predicted to be involved in mitochondrial electron transport, succinate to ubiquinone; nervous system development; and succinate metabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in Leigh disease; dilated cardiomyopathy 1GG; lung non-small cell carcinoma; mitochondrial complex II deficiency; and paraganglioma. Orthologous to human SDHA (succinate dehydrogenase complex flavoprotein subunit A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 297.9), kidney adult (RPKM 187.0) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Sdha in Genome Data Viewer
Location:
13 C1; 13 40.15 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (74470374..74498359, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (74322255..74350240, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene aryl-hydrocarbon receptor repressor Neighboring gene programmed cell death 6 Neighboring gene STARR-positive B cell enhancer ABC_E10800 Neighboring gene coiled-coil domain containing 127 Neighboring gene leucine rich repeat containing 14B Neighboring gene zinc finger protein 72 Neighboring gene BCL2-like 13 (apoptosis facilitator) pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables electron transfer activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on the CH-CH group of donors IEA
Inferred from Electronic Annotation
more info
 
enables succinate dehydrogenase (quinone) activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables succinate dehydrogenase (quinone) activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to succinate dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
Names
flavoprotein subunit of complex II
NP_075770.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023281.1NP_075770.1  succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor

    See identical proteins and their annotated locations for NP_075770.1

    Status: VALIDATED

    Source sequence(s)
    AK010561, AK034928
    Consensus CDS
    CCDS26643.1
    UniProtKB/Swiss-Prot
    Q0QF19, Q3UH25, Q3UKP7, Q3V4B1, Q8K2B3, Q921P5, Q9Z1Z4
    Related
    ENSMUSP00000022062.8, ENSMUST00000022062.8
    Conserved Domains (3) summary
    PTZ00139
    Location:35664
    PTZ00139; Succinate dehydrogenase [ubiquinone] flavoprotein subunit; Provisional
    pfam02910
    Location:513664
    Succ_DH_flav_C; Fumarate reductase flavoprotein C-term
    cl21454
    Location:85518
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    74470374..74498359 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)