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CEACAM1 carcinoembryonic antigen related cell adhesion molecule 1 [ Homo sapiens (human) ]

Gene ID: 634, updated on 30-Dec-2018

Summary

Official Symbol
CEACAM1provided by HGNC
Official Full Name
carcinoembryonic antigen related cell adhesion molecule 1provided by HGNC
Primary source
HGNC:HGNC:1814
See related
Ensembl:ENSG00000079385 MIM:109770
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BGP; BGP1; BGPI
Summary
This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined. [provided by RefSeq, May 2010]
Expression
Biased expression in colon (RPKM 99.7), esophagus (RPKM 21.9) and 12 other tissues See more
Orthologs

Genomic context

See CEACAM1 in Genome Data Viewer
Location:
19q13.2
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (42507306..42528509, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (43011458..43032661, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene LIPE antisense RNA 1 Neighboring gene RNA, U4 small nuclear 60, pseudogene Neighboring gene AN1-type zinc finger protein 5 pseudogene Neighboring gene uncharacterized LOC105372407 Neighboring gene carcinoembryonic antigen related cell adhesion molecule pseudogene 2 Neighboring gene carcinoembryonic antigen related cell adhesion molecule 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the expression of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) in human primary T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Cell surface interactions at the vascular wall, organism-specific biosystem (from REACTOME)
    Cell surface interactions at the vascular wall, organism-specific biosystemLeukocyte extravasation is a rigorously controlled process that guides white cell movement from the vascular lumen to sites of tissue inflammation. The powerful adhesive interactions that are require...
  • Extracellular matrix organization, organism-specific biosystem (from REACTOME)
    Extracellular matrix organization, organism-specific biosystemThe extracellular matrix is a component of all mammalian tissues, a network consisting largely of the fibrous proteins collagen, elastin and associated-microfibrils, fibronectin and laminins embedded...
  • Fibronectin matrix formation, organism-specific biosystem (from REACTOME)
    Fibronectin matrix formation, organism-specific biosystemFibronectin (FN1) is found in the extracellular matrix (ECM) of all cells as linear and branched networks that surround and connect neighbouring cells (Singh et al. 2010). Prior to matrix formation F...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
    Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin binding IPI
Inferred from Physical Interaction
more info
PubMed 
bile acid transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
calmodulin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
filamin binding IPI
Inferred from Physical Interaction
more info
PubMed 
identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
molecular_function ND
No biological Data available
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein dimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein homodimerization activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
angiogenesis NAS
Non-traceable Author Statement
more info
PubMed 
bile acid and bile salt transport ISS
Inferred from Sequence or Structural Similarity
more info
 
blood vessel development ISS
Inferred from Sequence or Structural Similarity
more info
 
cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
cell migration NAS
Non-traceable Author Statement
more info
PubMed 
cell-cell adhesion via plasma-membrane adhesion molecules ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to insulin stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
common myeloid progenitor cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
granulocyte colony-stimulating factor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
homophilic cell adhesion via plasma membrane adhesion molecules ISS
Inferred from Sequence or Structural Similarity
more info
 
homophilic cell adhesion via plasma membrane adhesion molecules NAS
Non-traceable Author Statement
more info
PubMed 
insulin catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
insulin receptor internalization ISS
Inferred from Sequence or Structural Similarity
more info
 
integrin-mediated signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
leukocyte migration TAS
Traceable Author Statement
more info
 
negative regulation of T cell mediated cytotoxicity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of T cell receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cytotoxic T cell degranulation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of fatty acid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of granulocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of hepatocyte proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of interleukin-1 production ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of lipid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of platelet aggregation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of vascular permeability ISS
Inferred from Sequence or Structural Similarity
more info
 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
positive regulation of vasculogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of blood vessel remodeling ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cell growth ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
regulation of endothelial cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of endothelial cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of epidermal growth factor receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of homophilic cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of phosphatidylinositol 3-kinase signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of sprouting angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
wound healing, spreading of cells IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with T cell receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
adherens junction ISS
Inferred from Sequence or Structural Similarity
more info
 
apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
apical plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
basal plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
cell junction IDA
Inferred from Direct Assay
more info
PubMed 
cell junction ISS
Inferred from Sequence or Structural Similarity
more info
 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cell surface ISS
Inferred from Sequence or Structural Similarity
more info
 
cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
lateral plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
membrane TAS
Traceable Author Statement
more info
PubMed 
microvillus membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
specific granule membrane TAS
Traceable Author Statement
more info
 
tertiary granule membrane TAS
Traceable Author Statement
more info
 
transport vesicle membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
carcinoembryonic antigen-related cell adhesion molecule 1
Names
CD66a antigen
antigen CD66
carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029051.2 RefSeqGene

    Range
    5001..26204
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001024912.2NP_001020083.1  carcinoembryonic antigen-related cell adhesion molecule 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001020083.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 3' coding region that results in a frameshift and an early stop codon, compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1. This variant has been referred to by multiple names, including BGPc, transmembrane carcinoembryonic antigen 3, TM3-CEA, and CEACAM1-4S.
    Source sequence(s)
    AC004785, BC014473, BC024164, DA432598, X16354
    Consensus CDS
    CCDS46089.1
    UniProtKB/Swiss-Prot
    P13688
    UniProtKB/TrEMBL
    Q3KRG8
    Related
    ENSP00000384709.3, ENST00000403444.7
    Conserved Domains (7) summary
    cd05740
    Location:146233
    Ig_CEACAM_D4; Fourth immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    cd05774
    Location:36140
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:157233
    IG_like; Immunoglobulin like
    pfam07679
    Location:317408
    I-set; Immunoglobulin I-set domain
    pfam13895
    Location:240318
    Ig_2; Immunoglobulin domain
    pfam15756
    Location:419451
    DUF4690; Domain of unknown function (DUF4690)
    cl11960
    Location:340415
    Ig; Immunoglobulin domain
  2. NM_001184813.1NP_001171742.1  carcinoembryonic antigen-related cell adhesion molecule 1 isoform 4 precursor

    See identical proteins and their annotated locations for NP_001171742.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate, in-frame, exon, compared to variant 1. The resulting protein (isoform 3) is shorter when it was compared to isoform 1.
    Source sequence(s)
    AC004785, DA432598, X14831
    Consensus CDS
    CCDS54273.1
    UniProtKB/Swiss-Prot
    P13688
    Related
    ENSP00000244291.6, ENST00000352591.9
    Conserved Domains (4) summary
    cd05740
    Location:146233
    Ig_CEACAM_D4; Fourth immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    cd05774
    Location:36140
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:157233
    IG_like; Immunoglobulin like
    pfam13895
    Location:240318
    Ig_2; Immunoglobulin domain
  3. NM_001184815.1NP_001171744.1  carcinoembryonic antigen-related cell adhesion molecule 1 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001171744.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has one and lacks a different alternate, in-frame, segment, compared to variant 1. The resulting protein (isoform 3) is shorter when it was compared to isoform 1. This variant has been referred to as 'alternative spliced isoform 3S' and 'short form 3'.
    Source sequence(s)
    AC004785, AK314211, DA432598, M76743, X16354
    Consensus CDS
    CCDS54274.1
    UniProtKB/Swiss-Prot
    P13688
    Related
    ENSP00000351165.2, ENST00000358394.7
    Conserved Domains (4) summary
    cd05740
    Location:146233
    Ig_CEACAM_D4; Fourth immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    cd05774
    Location:36140
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:157233
    IG_like; Immunoglobulin like
    pfam13895
    Location:240318
    Ig_2; Immunoglobulin domain
  4. NM_001184816.1NP_001171745.1  carcinoembryonic antigen-related cell adhesion molecule 1 isoform 5 precursor

    See identical proteins and their annotated locations for NP_001171745.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks two coding region segments, one of which shifts the reading frame, compared to variant 1. The resulting protein (isoform 5) has a shorter and distinct C-terminus when it is compared to isoform 1.
    Source sequence(s)
    AC004785, AY766113, DA432598, X16354
    Consensus CDS
    CCDS54272.1
    UniProtKB/Swiss-Prot
    P13688
    Related
    ENSP00000384083.1, ENST00000403461.5
    Conserved Domains (5) summary
    cd05740
    Location:146233
    Ig_CEACAM_D4; Fourth immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    cd05774
    Location:36140
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:157233
    IG_like; Immunoglobulin like
    pfam13895
    Location:240318
    Ig_2; Immunoglobulin domain
    pfam15756
    Location:323355
    DUF4690; Domain of unknown function (DUF4690)
  5. NM_001205344.1NP_001192273.1  carcinoembryonic antigen-related cell adhesion molecule 1 isoform 6 precursor

    See identical proteins and their annotated locations for NP_001192273.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks a segment, which results in a frameshift, compared to variant 1. The resulting protein (isoform 6) has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL833584, BC014473, BU161659, DA432598, J03858, X14831
    UniProtKB/Swiss-Prot
    P13688
    Conserved Domains (4) summary
    cd05740
    Location:146233
    Ig_CEACAM; Immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    pfam13895
    Location:240318
    Ig_2; Immunoglobulin domain
    cd05774
    Location:36140
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    cl11960
    Location:340415
    Ig; Immunoglobulin domain
  6. NM_001712.5NP_001703.2  carcinoembryonic antigen-related cell adhesion molecule 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001703.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1). This variant has been referred to by multiple names, including transmembrane carcinoembryonic antigen BGPa, TM1-CEA, and CEACAM1-4L.
    Source sequence(s)
    AC004785, DA432598, X16354
    Consensus CDS
    CCDS12609.1
    UniProtKB/Swiss-Prot
    P13688
    Related
    ENSP00000161559.6, ENST00000161559.10
    Conserved Domains (7) summary
    cd05740
    Location:146233
    Ig_CEACAM_D4; Fourth immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    cd05774
    Location:36140
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:157233
    IG_like; Immunoglobulin like
    pfam07679
    Location:317408
    I-set; Immunoglobulin I-set domain
    pfam13895
    Location:240318
    Ig_2; Immunoglobulin domain
    pfam15756
    Location:419451
    DUF4690; Domain of unknown function (DUF4690)
    cl11960
    Location:340415
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    42507306..42528509 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527206.2XP_011525508.1  carcinoembryonic antigen-related cell adhesion molecule 1 isoform X1

    See identical proteins and their annotated locations for XP_011525508.1

    UniProtKB/Swiss-Prot
    P13688
    Conserved Domains (4) summary
    cd05740
    Location:146233
    Ig_CEACAM_D4; Fourth immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    cd05774
    Location:36140
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:157233
    IG_like; Immunoglobulin like
    pfam13895
    Location:240318
    Ig_2; Immunoglobulin domain
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