Conserved Protein Domain Family

cd05740: Ig_CEACAM 
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Immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
Ig_CEACAM: Immunoglobulin (Ig)-like domain 4 in carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) protein subfamily. The CEA family is a group of anchored or secreted glycoproteins, expressed by epithelial cells, leukocytes, endothelial cells and placenta. The CEA family is divided into the CEACAM and pregnancy-specific glycoprotein (PSG) subfamilies. This group represents the CEACAM subfamily. CEACAM1 has many important cellular functions, it is a cell adhesion molecule, and a signaling molecule that regulates the growth of tumor cells, it is an angiogenic factor, and is a receptor for bacterial and viral pathogens, including mouse hepatitis virus (MHV). In mice, four isoforms of CEACAM1 generated by alternative splicing have either two [D1, D4] or four [D1-D4] Ig-like domains on the cell surface.
PSSM-Id: 143217
View PSSM: cd05740
Aligned: 4 rows
Threshold Bit Score: 132.4
Threshold Setting Gi: 82407267
Created: 10-Aug-2007
Updated: 18-Aug-2016
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
1E07_A        112 KPSISsnnsk---pvedkDAVAFTCEPEtqdaTYLWWVNNqslpvspr-lqlsngnRTLTLFNvtRNDTASYKCETQNpv 187
1E07_A        290 KPFITsnnsn---pvedeDAVALTCEPEiqntTYLWWVNNqslpvspr-lqlsndnRTLTLLSvtRNDVGPYECGIQNel 365
gi 165970602  140 EPVTAsgistdnkepqenQPVTLTCSANn--aEQILWGKNgvplppg--lslsadnRTLTFPRisRSDTGQYRCEASNav 215
gi 169154038  650 DPVSNvavnvgnqqpvynQPFTLTCTASgn-vDYIQWVLNgtdllphdritfsgdnSTLSFNNltLSDNGHYQCEASNei 728
1E07_A        188 saRRSDSVILNVL 200
1E07_A        366 svDHSDPVILNVL 378
gi 165970602  216 skIISDPYTLTVN 228
gi 169154038  729 snMTSSVYDLVVN 741
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