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RPS27A ribosomal protein S27a [ Homo sapiens (human) ]

Gene ID: 6233, updated on 2-Mar-2021

Summary

Official Symbol
RPS27Aprovided by HGNC
Official Full Name
ribosomal protein S27aprovided by HGNC
Primary source
HGNC:HGNC:10417
See related
Ensembl:ENSG00000143947 MIM:191343
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UBC; S27A; CEP80; UBA80; HEL112; UBCEP1; UBCEP80
Summary
Ubiquitin, a highly conserved protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome, is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin fused to an unrelated protein. This gene encodes a fusion protein consisting of ubiquitin at the N terminus and ribosomal protein S27a at the C terminus. When expressed in yeast, the protein is post-translationally processed, generating free ubiquitin monomer and ribosomal protein S27a. Ribosomal protein S27a is a component of the 40S subunit of the ribosome and belongs to the S27AE family of ribosomal proteins. It contains C4-type zinc finger domains and is located in the cytoplasm. Pseudogenes derived from this gene are present in the genome. As with ribosomal protein S27a, ribosomal protein L40 is also synthesized as a fusion protein with ubiquitin; similarly, ribosomal protein S30 is synthesized as a fusion protein with the ubiquitin-like protein fubi. Multiple alternatively spliced transcript variants that encode the same proteins have been identified.[provided by RefSeq, Sep 2008]
Expression
Ubiquitous expression in ovary (RPKM 575.2), lymph node (RPKM 347.6) and 25 other tissues See more
Orthologs
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Genomic context

See RPS27A in Genome Data Viewer
Location:
2p16.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (55231903..55235853)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (55459039..55462989)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374674 Neighboring gene clathrin heavy chain linker domain containing 1 Neighboring gene CDPF1 pseudogene 1 Neighboring gene mitochondrial translational initiation factor 2 Neighboring gene prolyl-tRNA synthetase associated domain containing 1, pseudogene Neighboring gene coiled-coil domain containing 88A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, ribosomal protein S27A (RPS27A), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tag IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
structural constituent of ribosome HDA PubMed 
ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
DNA damage response, detection of DNA damage TAS
Traceable Author Statement
more info
 
I-kappaB kinase/NF-kappaB signaling TAS
Traceable Author Statement
more info
 
JNK cascade TAS
Traceable Author Statement
more info
 
MyD88-dependent toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 
MyD88-independent toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 
SRP-dependent cotranslational protein targeting to membrane TAS
Traceable Author Statement
more info
 
TRIF-dependent toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 
Wnt signaling pathway TAS
Traceable Author Statement
more info
 
activation of MAPK activity TAS
Traceable Author Statement
more info
 
anaphase-promoting complex-dependent catabolic process TAS
Traceable Author Statement
more info
 
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
endosomal transport TAS
Traceable Author Statement
more info
 
error-free translesion synthesis TAS
Traceable Author Statement
more info
 
error-prone translesion synthesis TAS
Traceable Author Statement
more info
 
global genome nucleotide-excision repair TAS
Traceable Author Statement
more info
 
interleukin-1-mediated signaling pathway TAS
Traceable Author Statement
more info
 
interstrand cross-link repair TAS
Traceable Author Statement
more info
 
intracellular transport of virus TAS
Traceable Author Statement
more info
 
membrane organization TAS
Traceable Author Statement
more info
 
modification-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of apoptotic process TAS
Traceable Author Statement
more info
 
negative regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 
negative regulation of transforming growth factor beta receptor signaling pathway TAS
Traceable Author Statement
more info
 
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
Traceable Author Statement
more info
 
nucleotide-binding oligomerization domain containing signaling pathway TAS
Traceable Author Statement
more info
 
nucleotide-excision repair, DNA damage recognition TAS
Traceable Author Statement
more info
 
nucleotide-excision repair, DNA duplex unwinding TAS
Traceable Author Statement
more info
 
nucleotide-excision repair, DNA gap filling TAS
Traceable Author Statement
more info
 
nucleotide-excision repair, DNA incision TAS
Traceable Author Statement
more info
 
nucleotide-excision repair, DNA incision, 5'-to lesion TAS
Traceable Author Statement
more info
 
nucleotide-excision repair, preincision complex assembly TAS
Traceable Author Statement
more info
 
positive regulation of NF-kappaB transcription factor activity TAS
Traceable Author Statement
more info
 
positive regulation of apoptotic process TAS
Traceable Author Statement
more info
 
positive regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 
protein deubiquitination TAS
Traceable Author Statement
more info
 
protein polyubiquitination TAS
Traceable Author Statement
more info
 
protein targeting to peroxisome TAS
Traceable Author Statement
more info
 
protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ubiquitination TAS
Traceable Author Statement
more info
 
regulation of mRNA stability TAS
Traceable Author Statement
more info
 
regulation of transcription from RNA polymerase II promoter in response to hypoxia TAS
Traceable Author Statement
more info
 
stress-activated MAPK cascade TAS
Traceable Author Statement
more info
 
transcription-coupled nucleotide-excision repair TAS
Traceable Author Statement
more info
 
transforming growth factor beta receptor signaling pathway TAS
Traceable Author Statement
more info
 
translation IC
Inferred by Curator
more info
PubMed 
translational initiation TAS
Traceable Author Statement
more info
 
translesion synthesis TAS
Traceable Author Statement
more info
 
transmembrane transport TAS
Traceable Author Statement
more info
 
viral life cycle TAS
Traceable Author Statement
more info
 
viral transcription TAS
Traceable Author Statement
more info
 
virion assembly TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm HDA PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
cytosolic small ribosomal subunit HDA PubMed 
cytosolic small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosolic small ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
endocytic vesicle membrane TAS
Traceable Author Statement
more info
 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
endosome membrane TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
extracellular space HDA PubMed 
host cell IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
mitochondrial outer membrane TAS
Traceable Author Statement
more info
 
nucleolus HDA PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus HDA PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
small ribosomal subunit HDA PubMed 
vesicle HDA PubMed 

General protein information

Preferred Names
ubiquitin-40S ribosomal protein S27a
Names
40S ribosomal protein S27a
epididymis luminal protein 112
ubiquitin C
ubiquitin and ribosomal protein S27a
ubiquitin carboxyl extension protein 80
ubiquitin-CEP80

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_017017.1 RefSeqGene

    Range
    4975..8925
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001135592.2NP_001129064.1  ubiquitin-40S ribosomal protein S27a precursor

    See identical proteins and their annotated locations for NP_001129064.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC012358, AK225079, DB505702
    Consensus CDS
    CCDS33202.1
    UniProtKB/Swiss-Prot
    P62979
    UniProtKB/TrEMBL
    B2RDW1
    Related
    ENSP00000383981.3, ENST00000402285.7
    Conserved Domains (2) summary
    cd01803
    Location:176
    Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin
    pfam01599
    Location:103147
    Ribosomal_S27; Ribosomal protein S27a
  2. NM_001177413.1NP_001170884.1  ubiquitin-40S ribosomal protein S27a precursor

    See identical proteins and their annotated locations for NP_001170884.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC012358, BF678026, DA527860
    Consensus CDS
    CCDS33202.1
    UniProtKB/Swiss-Prot
    P62979
    UniProtKB/TrEMBL
    B2RDW1
    Related
    ENSP00000385659.1, ENST00000404735.1
    Conserved Domains (2) summary
    cd01803
    Location:176
    Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin
    pfam01599
    Location:103147
    Ribosomal_S27; Ribosomal protein S27a
  3. NM_002954.6NP_002945.1  ubiquitin-40S ribosomal protein S27a precursor

    See identical proteins and their annotated locations for NP_002945.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC012358
    Consensus CDS
    CCDS33202.1
    UniProtKB/Swiss-Prot
    P62979
    UniProtKB/TrEMBL
    B2RDW1
    Related
    ENSP00000272317.6, ENST00000272317.10
    Conserved Domains (2) summary
    cd01803
    Location:176
    Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin
    pfam01599
    Location:103147
    Ribosomal_S27; Ribosomal protein S27a

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    55231903..55235853
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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