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Zfp827 zinc finger protein 827 [ Mus musculus (house mouse) ]

Gene ID: 622675, updated on 2-Nov-2024

Summary

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Official Symbol
Zfp827provided by MGI
Official Full Name
zinc finger protein 827provided by MGI
Primary source
MGI:MGI:2444807
See related
Ensembl:ENSMUSG00000071064 AllianceGenome:MGI:2444807
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Znf827; 2810449M09Rik; D630040G17Rik
Summary
Predicted to enable NuRD complex binding activity. Predicted to be involved in several processes, including establishment of protein localization to telomere; negative regulation of shelterin complex assembly; and regulation of DNA-templated transcription. Predicted to be located in chromatin and chromosome, telomeric region. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleus. Orthologous to human ZNF827 (zinc finger protein 827). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in limb E14.5 (RPKM 3.9), whole brain E14.5 (RPKM 3.4) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Zfp827 in Genome Data Viewer
Location:
8 C1; 8 37.36 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (79753754..79920397)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (79027486..79193768)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_22004 Neighboring gene predicted gene, 39204 Neighboring gene STARR-positive B cell enhancer ABC_E8250 Neighboring gene predicted gene, 22044 Neighboring gene predicted gene, 30271 Neighboring gene RIKEN cDNA 1700011L22 gene Neighboring gene predicted gene, 30329 Neighboring gene methylmalonic aciduria (cobalamin deficiency) type A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  2. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables NuRD complex binding ISO
Inferred from Sequence Orthology
more info
  
enables NuRD complex binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in chromatin remodeling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in establishment of protein localization to telomere ISO
Inferred from Sequence Orthology
more info
  
involved_in establishment of protein localization to telomere ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of shelterin complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of shelterin complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in telomere maintenance ISO
Inferred from Sequence Orthology
more info
  
involved_in telomere maintenance ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in chromatin ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome, telomeric region ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
zinc finger protein 827

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001294279.2 → NP_001281208.1  zinc finger protein 827 isoform 2

    See identical proteins and their annotated locations for NP_001281208.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC101790, AC123597
    Consensus CDS
    CCDS80900.1
    UniProtKB/TrEMBL
    G5E8U2
    Related
    ENSMUSP00000113199.2, ENSMUST00000119254.8
    Conserved Domains (4) summary
    COG5048
    Location:351 → 440
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:373 → 393
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:816 → 836
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:385 → 410
    zf-H2C2_2; Zinc-finger double domain

  2. NM_178267.4 → NP_839998.2  zinc finger protein 827 isoform 1

    See identical proteins and their annotated locations for NP_839998.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC101790, AC123597
    Consensus CDS
    CCDS52604.1
    UniProtKB/Swiss-Prot
    B2RXD8, Q505G8, Q5M7B0
    Related
    ENSMUSP00000096214.3, ENSMUST00000098614.9
    Conserved Domains (4) summary
    COG5048
    Location:351 → 440
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:373 → 393
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:816 → 836
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:385 → 410
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    79753754..79920397
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531246.3 → XP_006531309.1  zinc finger protein 827 isoform X5

    UniProtKB/TrEMBL
    A0A571BE87
    Conserved Domains (5) summary
    COG5048
    Location:351 → 440
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:373 → 393
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:816 → 836
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:1153 → 1177
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:1138 → 1162
    zf-H2C2_5; C2H2-type zinc-finger domain

  2. XM_030243704.2 → XP_030099564.1  zinc finger protein 827 isoform X6

    UniProtKB/TrEMBL
    A0A571BE87
    Related
    ENSMUSP00000158613.2, ENSMUST00000238669.2
    Conserved Domains (5) summary
    COG5048
    Location:351 → 440
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:373 → 393
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:816 → 836
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:1147 → 1171
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:1132 → 1156
    zf-H2C2_5; C2H2-type zinc-finger domain

  3. XM_036154209.1 → XP_036010102.1  zinc finger protein 827 isoform X7

    UniProtKB/TrEMBL
    A0A571BE87
    Conserved Domains (5) summary
    COG5048
    Location:344 → 433
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:366 → 386
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:809 → 829
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:1146 → 1170
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:1131 → 1155
    zf-H2C2_5; C2H2-type zinc-finger domain

  4. XM_036154222.1 → XP_036010115.1  zinc finger protein 827 isoform X13

    Conserved Domains (3) summary
    COG5048
    Location:399 → 488
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:421 → 441
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:433 → 458
    zf-H2C2_2; Zinc-finger double domain

  5. XM_036154223.1 → XP_036010116.1  zinc finger protein 827 isoform X14

    Conserved Domains (2) summary
    COG5048
    Location:399 → 488
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:421 → 441
    ZF_C2H2; C2H2 Zn finger [structural motif]

  6. XM_036154212.1 → XP_036010105.1  zinc finger protein 827 isoform X10

    Conserved Domains (4) summary
    COG5048
    Location:399 → 488
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:421 → 441
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:864 → 884
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:862 → 884
    zf-C2H2; Zinc finger, C2H2 type

  7. XM_036154215.1 → XP_036010108.1  zinc finger protein 827 isoform X10

    Conserved Domains (4) summary
    COG5048
    Location:399 → 488
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:421 → 441
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:864 → 884
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:862 → 884
    zf-C2H2; Zinc finger, C2H2 type

  8. XM_036154213.1 → XP_036010106.1  zinc finger protein 827 isoform X10

    Conserved Domains (4) summary
    COG5048
    Location:399 → 488
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:421 → 441
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:864 → 884
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:862 → 884
    zf-C2H2; Zinc finger, C2H2 type

  9. XM_036154211.1 → XP_036010104.1  zinc finger protein 827 isoform X9

    Conserved Domains (4) summary
    COG5048
    Location:399 → 488
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:421 → 441
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:864 → 884
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:862 → 884
    zf-C2H2; Zinc finger, C2H2 type

  10. XM_036154221.1 → XP_036010114.1  zinc finger protein 827 isoform X12

    Conserved Domains (4) summary
    COG5048
    Location:399 → 488
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:421 → 441
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:864 → 884
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:862 → 884
    zf-C2H2; Zinc finger, C2H2 type

  11. XM_036154219.1 → XP_036010112.1  zinc finger protein 827 isoform X12

    Conserved Domains (4) summary
    COG5048
    Location:399 → 488
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:421 → 441
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:864 → 884
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:862 → 884
    zf-C2H2; Zinc finger, C2H2 type

  12. XM_036154220.1 → XP_036010113.1  zinc finger protein 827 isoform X12

    Conserved Domains (4) summary
    COG5048
    Location:399 → 488
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:421 → 441
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:864 → 884
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:862 → 884
    zf-C2H2; Zinc finger, C2H2 type

  13. XM_036154218.1 → XP_036010111.1  zinc finger protein 827 isoform X11

    Conserved Domains (4) summary
    COG5048
    Location:399 → 488
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:421 → 441
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:864 → 884
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:862 → 884
    zf-C2H2; Zinc finger, C2H2 type

  14. XM_036154216.1 → XP_036010109.1  zinc finger protein 827 isoform X10

    Conserved Domains (4) summary
    COG5048
    Location:399 → 488
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:421 → 441
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:864 → 884
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:862 → 884
    zf-C2H2; Zinc finger, C2H2 type

  15. XM_036154214.1 → XP_036010107.1  zinc finger protein 827 isoform X10

    Conserved Domains (4) summary
    COG5048
    Location:399 → 488
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:421 → 441
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:864 → 884
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:862 → 884
    zf-C2H2; Zinc finger, C2H2 type

  16. XM_036154217.1 → XP_036010110.1  zinc finger protein 827 isoform X10

    Conserved Domains (4) summary
    COG5048
    Location:399 → 488
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:421 → 441
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:864 → 884
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:862 → 884
    zf-C2H2; Zinc finger, C2H2 type

  17. XM_006531242.5 → XP_006531305.1  zinc finger protein 827 isoform X1

    UniProtKB/TrEMBL
    A0A571BE87
    Conserved Domains (5) summary
    COG5048
    Location:399 → 488
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:421 → 441
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:864 → 884
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:1201 → 1225
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:1186 → 1210
    zf-H2C2_5; C2H2-type zinc-finger domain

  18. XM_036154206.1 → XP_036010099.1  zinc finger protein 827 isoform X2

    UniProtKB/TrEMBL
    A0A571BE87
    Conserved Domains (5) summary
    COG5048
    Location:399 → 488
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:421 → 441
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:864 → 884
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:1197 → 1221
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:1182 → 1206
    zf-H2C2_5; C2H2-type zinc-finger domain

  19. XM_036154207.1 → XP_036010100.1  zinc finger protein 827 isoform X3

    UniProtKB/TrEMBL
    A0A571BE87
    Conserved Domains (5) summary
    COG5048
    Location:399 → 488
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:421 → 441
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:864 → 884
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:1195 → 1219
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:1180 → 1204
    zf-H2C2_5; C2H2-type zinc-finger domain

  20. XM_036154208.1 → XP_036010101.1  zinc finger protein 827 isoform X4

    UniProtKB/TrEMBL
    A0A571BE87
    Conserved Domains (5) summary
    COG5048
    Location:399 → 488
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:421 → 441
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:864 → 884
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:1191 → 1215
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:1176 → 1200
    zf-H2C2_5; C2H2-type zinc-finger domain

  21. XM_036154210.1 → XP_036010103.1  zinc finger protein 827 isoform X8

    UniProtKB/TrEMBL
    A0A571BE87
    Conserved Domains (5) summary
    COG5048
    Location:399 → 488
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:421 → 441
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:786 → 806
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:1123 → 1147
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:1108 → 1132
    zf-H2C2_5; C2H2-type zinc-finger domain

RNA

  1. XR_004934863.1 RNA Sequence

  2. XR_004934865.1 RNA Sequence

  3. XR_004934864.1 RNA Sequence

  4. XR_004934866.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q505G8.2 GenPept UniProtKB/Swiss-Prot:Q505G8

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