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Zfp827 zinc finger protein 827 [ Mus musculus (house mouse) ]

Gene ID: 622675, updated on 30-Apr-2024

Summary

Official Symbol
Zfp827provided by MGI
Official Full Name
zinc finger protein 827provided by MGI
Primary source
MGI:MGI:2444807
See related
Ensembl:ENSMUSG00000071064 AllianceGenome:MGI:2444807
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Znf827; 2810449M09Rik; D630040G17Rik
Summary
Predicted to enable DNA binding activity and metal ion binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZNF827 (zinc finger protein 827). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 3.9), whole brain E14.5 (RPKM 3.4) and 27 other tissues See more
Orthologs
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Genomic context

See Zfp827 in Genome Data Viewer
Location:
8 C1; 8 37.36 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (79753754..79920397)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (79027486..79193768)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_22004 Neighboring gene predicted gene, 39204 Neighboring gene STARR-positive B cell enhancer ABC_E8250 Neighboring gene predicted gene, 22044 Neighboring gene predicted gene, 30271 Neighboring gene RIKEN cDNA 1700011L22 gene Neighboring gene predicted gene, 30329 Neighboring gene methylmalonic aciduria (cobalamin deficiency) type A

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables NuRD complex binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001294279.2NP_001281208.1  zinc finger protein 827 isoform 2

    See identical proteins and their annotated locations for NP_001281208.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC101790, AC123597
    Consensus CDS
    CCDS80900.1
    UniProtKB/TrEMBL
    G5E8U2
    Related
    ENSMUSP00000113199.2, ENSMUST00000119254.8
    Conserved Domains (4) summary
    COG5048
    Location:351440
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:373393
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:816836
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:385410
    zf-H2C2_2; Zinc-finger double domain
  2. NM_178267.4NP_839998.2  zinc finger protein 827 isoform 1

    See identical proteins and their annotated locations for NP_839998.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC101790, AC123597
    Consensus CDS
    CCDS52604.1
    UniProtKB/Swiss-Prot
    B2RXD8, Q505G8, Q5M7B0
    Related
    ENSMUSP00000096214.3, ENSMUST00000098614.9
    Conserved Domains (4) summary
    COG5048
    Location:351440
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:373393
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:816836
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:385410
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    79753754..79920397
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531246.3XP_006531309.1  zinc finger protein 827 isoform X5

    UniProtKB/TrEMBL
    A0A571BE87
    Conserved Domains (5) summary
    COG5048
    Location:351440
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:373393
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:816836
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:11531177
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:11381162
    zf-H2C2_5; C2H2-type zinc-finger domain
  2. XM_030243704.2XP_030099564.1  zinc finger protein 827 isoform X6

    UniProtKB/TrEMBL
    A0A571BE87
    Related
    ENSMUSP00000158613.2, ENSMUST00000238669.2
    Conserved Domains (5) summary
    COG5048
    Location:351440
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:373393
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:816836
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:11471171
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:11321156
    zf-H2C2_5; C2H2-type zinc-finger domain
  3. XM_036154209.1XP_036010102.1  zinc finger protein 827 isoform X7

    UniProtKB/TrEMBL
    A0A571BE87
    Conserved Domains (5) summary
    COG5048
    Location:344433
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:366386
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:809829
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:11461170
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:11311155
    zf-H2C2_5; C2H2-type zinc-finger domain
  4. XM_036154222.1XP_036010115.1  zinc finger protein 827 isoform X13

    Conserved Domains (3) summary
    COG5048
    Location:399488
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:421441
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:433458
    zf-H2C2_2; Zinc-finger double domain
  5. XM_036154223.1XP_036010116.1  zinc finger protein 827 isoform X14

    Conserved Domains (2) summary
    COG5048
    Location:399488
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:421441
    ZF_C2H2; C2H2 Zn finger [structural motif]
  6. XM_036154212.1XP_036010105.1  zinc finger protein 827 isoform X10

    Conserved Domains (4) summary
    COG5048
    Location:399488
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:421441
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:864884
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:862884
    zf-C2H2; Zinc finger, C2H2 type
  7. XM_036154215.1XP_036010108.1  zinc finger protein 827 isoform X10

    Conserved Domains (4) summary
    COG5048
    Location:399488
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:421441
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:864884
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:862884
    zf-C2H2; Zinc finger, C2H2 type
  8. XM_036154213.1XP_036010106.1  zinc finger protein 827 isoform X10

    Conserved Domains (4) summary
    COG5048
    Location:399488
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:421441
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:864884
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:862884
    zf-C2H2; Zinc finger, C2H2 type
  9. XM_036154211.1XP_036010104.1  zinc finger protein 827 isoform X9

    Conserved Domains (4) summary
    COG5048
    Location:399488
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:421441
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:864884
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:862884
    zf-C2H2; Zinc finger, C2H2 type
  10. XM_036154221.1XP_036010114.1  zinc finger protein 827 isoform X12

    Conserved Domains (4) summary
    COG5048
    Location:399488
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:421441
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:864884
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:862884
    zf-C2H2; Zinc finger, C2H2 type
  11. XM_036154219.1XP_036010112.1  zinc finger protein 827 isoform X12

    Conserved Domains (4) summary
    COG5048
    Location:399488
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:421441
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:864884
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:862884
    zf-C2H2; Zinc finger, C2H2 type
  12. XM_036154220.1XP_036010113.1  zinc finger protein 827 isoform X12

    Conserved Domains (4) summary
    COG5048
    Location:399488
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:421441
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:864884
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:862884
    zf-C2H2; Zinc finger, C2H2 type
  13. XM_036154218.1XP_036010111.1  zinc finger protein 827 isoform X11

    Conserved Domains (4) summary
    COG5048
    Location:399488
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:421441
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:864884
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:862884
    zf-C2H2; Zinc finger, C2H2 type
  14. XM_036154216.1XP_036010109.1  zinc finger protein 827 isoform X10

    Conserved Domains (4) summary
    COG5048
    Location:399488
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:421441
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:864884
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:862884
    zf-C2H2; Zinc finger, C2H2 type
  15. XM_036154214.1XP_036010107.1  zinc finger protein 827 isoform X10

    Conserved Domains (4) summary
    COG5048
    Location:399488
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:421441
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:864884
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:862884
    zf-C2H2; Zinc finger, C2H2 type
  16. XM_036154217.1XP_036010110.1  zinc finger protein 827 isoform X10

    Conserved Domains (4) summary
    COG5048
    Location:399488
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:421441
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:864884
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:862884
    zf-C2H2; Zinc finger, C2H2 type
  17. XM_006531242.5XP_006531305.1  zinc finger protein 827 isoform X1

    UniProtKB/TrEMBL
    A0A571BE87
    Conserved Domains (5) summary
    COG5048
    Location:399488
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:421441
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:864884
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:12011225
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:11861210
    zf-H2C2_5; C2H2-type zinc-finger domain
  18. XM_036154206.1XP_036010099.1  zinc finger protein 827 isoform X2

    UniProtKB/TrEMBL
    A0A571BE87
    Conserved Domains (5) summary
    COG5048
    Location:399488
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:421441
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:864884
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:11971221
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:11821206
    zf-H2C2_5; C2H2-type zinc-finger domain
  19. XM_036154207.1XP_036010100.1  zinc finger protein 827 isoform X3

    UniProtKB/TrEMBL
    A0A571BE87
    Conserved Domains (5) summary
    COG5048
    Location:399488
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:421441
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:864884
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:11951219
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:11801204
    zf-H2C2_5; C2H2-type zinc-finger domain
  20. XM_036154208.1XP_036010101.1  zinc finger protein 827 isoform X4

    UniProtKB/TrEMBL
    A0A571BE87
    Conserved Domains (5) summary
    COG5048
    Location:399488
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:421441
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:864884
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:11911215
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:11761200
    zf-H2C2_5; C2H2-type zinc-finger domain
  21. XM_036154210.1XP_036010103.1  zinc finger protein 827 isoform X8

    UniProtKB/TrEMBL
    A0A571BE87
    Conserved Domains (5) summary
    COG5048
    Location:399488
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:421441
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:786806
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:11231147
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:11081132
    zf-H2C2_5; C2H2-type zinc-finger domain

RNA

  1. XR_004934863.1 RNA Sequence

  2. XR_004934865.1 RNA Sequence

  3. XR_004934864.1 RNA Sequence

  4. XR_004934866.1 RNA Sequence