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ZNF827 zinc finger protein 827 [ Homo sapiens (human) ]

Gene ID: 152485, updated on 11-Jun-2021

Summary

Official Symbol
ZNF827provided by HGNC
Official Full Name
zinc finger protein 827provided by HGNC
Primary source
HGNC:HGNC:27193
See related
Ensembl:ENSG00000151612 MIM:617962
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in prostate (RPKM 4.9), thyroid (RPKM 2.3) and 23 other tissues See more
Orthologs
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Genomic context

See ZNF827 in Genome Data Viewer
Location:
4q31.21-q31.22
Exon count:
19
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (145757627..145938823, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (146678779..146859975, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2491 Neighboring gene nuclear receptor coactivator 4 pseudogene 3 Neighboring gene metabolism of cobalamin associated A Neighboring gene chromosome 4 open reading frame 51 Neighboring gene uncharacterized LOC105377468 Neighboring gene uncharacterized LOC105377469 Neighboring gene long intergenic non-protein coding RNA 1095

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association study of behavioral disinhibition.
GeneReviews: Not available
Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
GeneReviews: Not available
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
GeneReviews: Not available
GWAS of dental caries patterns in the permanent dentition.
GeneReviews: Not available
Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001306215.2NP_001293144.1  zinc finger protein 827 isoform 1

    See identical proteins and their annotated locations for NP_001293144.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents longer isoform (1).
    Source sequence(s)
    AK091130, AK094136, AK225805, BC033248, BU616184, BX112429
    Consensus CDS
    CCDS77968.1
    UniProtKB/Swiss-Prot
    Q17R98
    UniProtKB/TrEMBL
    B3KSR1
    Related
    ENSP00000421863.1, ENST00000508784.6
    Conserved Domains (4) summary
    COG5048
    Location:355443
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:376396
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:819839
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:388413
    zf-H2C2_2; Zinc-finger double domain
  2. NM_178835.5NP_849157.2  zinc finger protein 827 isoform 2

    See identical proteins and their annotated locations for NP_849157.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and uses an alternate splice site that results in a shorter 3' coding region compared to variant 1. It encodes isoform 2, which has a shorter C-terminus compared to isoform 1.
    Source sequence(s)
    AK091130, AK094136, AK225805, BC033248, BC117407, BM557137, BU616184, BX112429
    Consensus CDS
    CCDS34072.1
    UniProtKB/Swiss-Prot
    Q17R98
    UniProtKB/TrEMBL
    B3KSR1
    Related
    ENSP00000368761.4, ENST00000379448.9
    Conserved Domains (4) summary
    COG5048
    Location:355443
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:376396
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:819839
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:388413
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    145757627..145938823 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017007768.2XP_016863257.1  zinc finger protein 827 isoform X2

  2. XM_017007770.2XP_016863259.1  zinc finger protein 827 isoform X4

  3. XM_011531634.3XP_011529936.1  zinc finger protein 827 isoform X1

    Related
    ENSP00000424541.2, ENST00000503462.3
    Conserved Domains (4) summary
    COG5048
    Location:355443
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:376396
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:819839
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:11461170
    zf-H2C2_2; Zinc-finger double domain
  4. XM_011531635.2XP_011529937.1  zinc finger protein 827 isoform X3

    See identical proteins and their annotated locations for XP_011529937.1

    Conserved Domains (4) summary
    COG5048
    Location:343431
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:364384
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:807827
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:11341158
    zf-H2C2_2; Zinc-finger double domain
  5. XM_017007769.1XP_016863258.1  zinc finger protein 827 isoform X3

    Conserved Domains (4) summary
    COG5048
    Location:343431
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:364384
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:807827
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:11341158
    zf-H2C2_2; Zinc-finger double domain
  6. XM_017007777.2XP_016863266.1  zinc finger protein 827 isoform X8

    Conserved Domains (3) summary
    sd00017
    Location:516536
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:230250
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:557581
    zf-H2C2_2; Zinc-finger double domain
  7. XM_011531645.2XP_011529947.1  zinc finger protein 827 isoform X9

    Conserved Domains (3) summary
    sd00017
    Location:437457
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:151171
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:478502
    zf-H2C2_2; Zinc-finger double domain
  8. XM_017007773.2XP_016863262.1  zinc finger protein 827 isoform X6

    UniProtKB/Swiss-Prot
    Q17R98
    Conserved Domains (4) summary
    COG5048
    Location:355443
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:376396
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:819839
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:388413
    zf-H2C2_2; Zinc-finger double domain
  9. XM_017007772.2XP_016863261.1  zinc finger protein 827 isoform X6

    UniProtKB/Swiss-Prot
    Q17R98
    Related
    ENSP00000498532.1, ENST00000652097.1
    Conserved Domains (4) summary
    COG5048
    Location:355443
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:376396
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:819839
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:388413
    zf-H2C2_2; Zinc-finger double domain
  10. XM_017007774.2XP_016863263.1  zinc finger protein 827 isoform X6

    UniProtKB/Swiss-Prot
    Q17R98
    Related
    ENSP00000499364.1, ENST00000656985.1
    Conserved Domains (4) summary
    COG5048
    Location:355443
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:376396
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:819839
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:388413
    zf-H2C2_2; Zinc-finger double domain
  11. XM_017007771.2XP_016863260.1  zinc finger protein 827 isoform X5

  12. XM_017007775.2XP_016863264.1  zinc finger protein 827 isoform X6

    UniProtKB/Swiss-Prot
    Q17R98
    Conserved Domains (4) summary
    COG5048
    Location:355443
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:376396
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:819839
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:388413
    zf-H2C2_2; Zinc-finger double domain
  13. XM_017007776.2XP_016863265.1  zinc finger protein 827 isoform X7

RNA

  1. XR_001741145.2 RNA Sequence

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