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ROCK1 Rho associated coiled-coil containing protein kinase 1 [ Homo sapiens (human) ]

Gene ID: 6093, updated on 13-Jun-2021

Summary

Official Symbol
ROCK1provided by HGNC
Official Full Name
Rho associated coiled-coil containing protein kinase 1provided by HGNC
Primary source
HGNC:HGNC:10251
See related
Ensembl:ENSG00000067900 MIM:601702
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ROCK-I; P160ROCK
Summary
This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18. [provided by RefSeq, Aug 2015]
Expression
Ubiquitous expression in bone marrow (RPKM 22.1), fat (RPKM 16.6) and 25 other tissues See more
Orthologs
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Genomic context

See ROCK1 in Genome Data Viewer
Location:
18q11.1
Exon count:
33
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (20946906..21111813, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (18526867..18691774, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 30B pseudogene Neighboring gene RNA, U6 small nuclear 721, pseudogene Neighboring gene vomeronasal 1 receptor 75 pseudogene Neighboring gene Sharpr-MPRA regulatory region 9828 Neighboring gene ribosomal protein L21 pseudogene 128 Neighboring gene RNA, U6 small nuclear 120, pseudogene

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of ROCK1 PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Filamin-A-dependent activation of the RhoA-ROCK-LIMK-cofilin pathway is a major event in HIV-1 gp120-induced receptor clustering PubMed
Tat tat HIV-1 Tat downregulates OCLN (occludin) and LRP1 and upregulates AGER (RAGE), and in a RhoA/ROCK1 dependent manner as shown through hydroxyfasudil inhibition in hCMEC/D3 cells PubMed
tat HIV-1 Tat-mediated downregulation of occludin expression requires activities of the RhoA and p160-Rho-associated coiled kinase (ROCK) proteins in primary human brain micro vascular endothelial cells PubMed
matrix gag HIV-1 MA-induced upregulation of collagen-I and alpha-SMA expression is dependent on CXCR2 via the Rho/ROCK-1 pathway PubMed
gag HIV-1 p17-mediated activation of the Rho/ROCK-signaling pathway is required for p17-mediated monocyte adhesion and migration PubMed
gag HIV-1 p17-induced activation of PTEN is regulated by RhoA-associated kinase (ROCK) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • PRO0435, MGC43611, MGC131603

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables Rho-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables Rho-dependent protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables aspartic-type endopeptidase inhibitor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity TAS
Traceable Author Statement
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables protein threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
 
enables tau protein binding NAS
Non-traceable Author Statement
more info
PubMed 
enables tau-protein kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
involved_in I-kappaB kinase/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in Rho protein signal transduction IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in actin cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in actomyosin structure organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in aortic valve morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in blood vessel diameter maintenance ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cortical actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cortical actin cytoskeleton organization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cortical actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryonic morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ephrin receptor signaling pathway TAS
Traceable Author Statement
more info
 
involved_in epithelial to mesenchymal transition ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in glomerular visceral epithelial cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in leukocyte cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in leukocyte migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in leukocyte tethering or rolling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mRNA destabilization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in membrane to membrane docking IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mitotic cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in myoblast migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of amyloid precursor protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of amyloid-beta formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of bicellular tight junction assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of biomineral tissue development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of membrane protein ectodomain proteolysis TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of myosin-light-chain-phosphatase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of myosin-light-chain-phosphatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of protein binding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neuron projection arborization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in neuron projection development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in neutrophil degranulation TAS
Traceable Author Statement
more info
 
involved_in peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-threonine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of amyloid-beta clearance IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of autophagy IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of cardiac muscle hypertrophy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of connective tissue replacement IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of focal adhesion assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein localization to plasma membrane IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of actin cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of actin cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of actin cytoskeleton organization TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of amyloid-beta formation TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of angiotensin-activated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of autophagy TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of cell adhesion TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of cell junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cell motility TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of establishment of cell polarity TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of establishment of endothelial barrier IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of establishment of endothelial barrier IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of focal adhesion assembly TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of keratinocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of microtubule cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of neuron differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of stress fiber assembly TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of synaptic vesicle endocytosis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in response to angiotensin ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to transforming growth factor beta ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
involved_in smooth muscle contraction TAS
Traceable Author Statement
more info
PubMed 
involved_in vascular endothelial growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
located_in bleb IEA
Inferred from Electronic Annotation
more info
 
located_in centriole IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cytoplasmic stress granule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasmic stress granule ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in lamellipodium ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in ruffle ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in secretory granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
rho-associated protein kinase 1
Names
p160 ROCK-1
renal carcinoma antigen NY-REN-35
NP_005397.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_042178.2 RefSeqGene

    Range
    5039..169946
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1005

mRNA and Protein(s)

  1. NM_005406.3NP_005397.1  rho-associated protein kinase 1

    See identical proteins and their annotated locations for NP_005397.1

    Status: REVIEWED

    Source sequence(s)
    AC036178, AK057038, AU121527, U43195
    Consensus CDS
    CCDS11870.2
    UniProtKB/Swiss-Prot
    Q13464
    Related
    ENSP00000382697.1, ENST00000399799.3
    Conserved Domains (7) summary
    cd11639
    Location:489554
    HR1_ROCK1; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rho-associated coiled-coil containing protein kinase 1
    smart00220
    Location:76338
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG0419
    Location:4221027
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd00029
    Location:12291275
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01242
    Location:11191225
    PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain
    cd05622
    Location:2406
    STKc_ROCK1; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase 1
    pfam08912
    Location:9491014
    Rho_Binding; Rho Binding

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    20946906..21111813 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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