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Rock1 Rho-associated coiled-coil containing protein kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 19877, updated on 19-Feb-2024

Summary

Official Symbol
Rock1provided by MGI
Official Full Name
Rho-associated coiled-coil containing protein kinase 1provided by MGI
Primary source
MGI:MGI:107927
See related
Ensembl:ENSMUSG00000024290 AllianceGenome:MGI:107927
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rock-I; 1110055K06Rik
Summary
Predicted to enable Rho-dependent protein serine/threonine kinase activity; aspartic-type endopeptidase inhibitor activity; and small GTPase binding activity. Involved in several processes, including glomerular visceral epithelial cell migration; positive regulation of focal adhesion assembly; and response to angiotensin. Acts upstream of or within several processes, including apical constriction; bleb assembly; and negative regulation of neuron apoptotic process. Located in several cellular components, including cytoplasmic stress granule; lamellipodium; and ruffle. Is expressed in several structures, including central nervous system; genitourinary system; gut; heart; and skeletal muscle. Orthologous to human ROCK1 (Rho associated coiled-coil containing protein kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 7.8), placenta adult (RPKM 6.0) and 28 other tissues See more
Orthologs
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Genomic context

See Rock1 in Genome Data Viewer
Location:
18 A1; 18 4.91 cM
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (10064401..10182225, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (10064401..10182251, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_43785 Neighboring gene developmental pluripotency associated 4 pseudogene Neighboring gene STARR-seq mESC enhancer starr_43786 Neighboring gene THO complex 1 Neighboring gene ubiquitin specific peptidase 14 Neighboring gene STARR-seq mESC enhancer starr_43787 Neighboring gene STARR-seq mESC enhancer starr_43788 Neighboring gene STARR-seq mESC enhancer starr_43789 Neighboring gene LSM6 homolog, U6 small nuclear RNA associated pseudogene Neighboring gene predicted gene, 26244 Neighboring gene STARR-seq mESC enhancer starr_43790 Neighboring gene high mobility group box 3 pseudogene Neighboring gene dyskeratosis congenita 1, dyskerin homolog pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (14)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables Rho-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables Rho-dependent protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables aspartic-type endopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within actin cytoskeleton organization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in actin cytoskeleton organization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in actomyosin structure organization IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within apical constriction IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within bleb assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in blood vessel diameter maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in cortical actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cortical actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in embryonic morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in epithelial to mesenchymal transition IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in leukocyte cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in leukocyte migration ISO
Inferred from Sequence Orthology
more info
 
involved_in leukocyte tethering or rolling ISO
Inferred from Sequence Orthology
more info
 
involved_in mRNA destabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in membrane to membrane docking ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of motor neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in myoblast migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of amyloid precursor protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of amyloid-beta formation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of bicellular tight junction assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of motor neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of myosin-light-chain-phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron projection arborization ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-threonine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in podocyte cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of amyloid-beta clearance ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cardiac muscle hypertrophy ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of connective tissue replacement ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of focal adhesion assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of actin filament-based process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of angiotensin-activated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of establishment of endothelial barrier ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of keratinocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of synapse maturation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of synapse maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of synaptic vesicle endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in response to angiotensin IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in response to transforming growth factor beta IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in response to transforming growth factor beta ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
is_active_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in Schaffer collateral - CA1 synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of amyloid-beta complex ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasmic stress granule IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in ruffle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
rho-associated protein kinase 1
Names
Rho-associated coiled-coil forming kinase 1
p160 ROCK-1
p160ROCK
rho-associated, coiled-coil-containing protein kinase 1
rho-associated, coiled-coil-containing protein kinase I
NP_033097.1
XP_006525788.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009071.2NP_033097.1  rho-associated protein kinase 1

    See identical proteins and their annotated locations for NP_033097.1

    Status: VALIDATED

    Source sequence(s)
    AA163962, AK077297, AK149793, DR754490, U58512
    Consensus CDS
    CCDS29053.2
    UniProtKB/Swiss-Prot
    P70335, Q8C3G4, Q8C7H0
    Related
    ENSMUSP00000069549.6, ENSMUST00000067947.7
    Conserved Domains (7) summary
    cd11639
    Location:489554
    HR1_ROCK1; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rho-associated coiled-coil containing protein kinase 1
    smart00220
    Location:76338
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1196
    Location:4221097
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00029
    Location:12291283
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01242
    Location:11191225
    PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain
    cd05622
    Location:2406
    STKc_ROCK1; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase 1
    pfam08912
    Location:9491014
    Rho_Binding; Rho Binding

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    10064401..10182225 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006525725.2XP_006525788.1  rho-associated protein kinase 1 isoform X1

    UniProtKB/Swiss-Prot
    P70335
    Conserved Domains (5) summary
    cd11639
    Location:488553
    HR1_ROCK1; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rho-associated coiled-coil containing protein kinase 1
    COG1196
    Location:4191096
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00029
    Location:12281282
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01242
    Location:11181224
    PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain
    cd05622
    Location:2406
    STKc_ROCK1; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase 1

RNA

  1. XR_001782350.3 RNA Sequence