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Zfp24 zinc finger protein 24 [ Mus musculus (house mouse) ]

Gene ID: 59057, updated on 2-Nov-2024

Summary

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Official Symbol
Zfp24provided by MGI
Official Full Name
zinc finger protein 24provided by MGI
Primary source
MGI:MGI:1929704
See related
Ensembl:ENSMUSG00000051469 AllianceGenome:MGI:1929704
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KOX17; ZF-12; Znf24; Zfp191; 3526401F17Rik; 5033419P20Rik
Summary
Enables sequence-specific DNA binding activity. Involved in myelination. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb primordium; and sensory organ. Orthologous to human ZNF24 (zinc finger protein 24). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 5.8), CNS E14 (RPKM 4.0) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Zfp24 in Genome Data Viewer
Location:
18 A2; 18 12.55 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (24142774..24155294, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (24009717..24020813, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene zinc finger and SCAN domain containing 30 Neighboring gene zinc finger protein 397 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:24145637-24145876 Neighboring gene STARR-seq mESC enhancer starr_44051 Neighboring gene zinc finger protein 35 Neighboring gene STARR-positive B cell enhancer ABC_E8705 Neighboring gene STARR-seq mESC enhancer starr_44054 Neighboring gene ribosomal protein S8 pseudogene Neighboring gene STARR-seq mESC enhancer starr_44055 Neighboring gene predicted gene, 18085

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Isolation, cloning, and expression of a new murine zinc finger encoding gene. Prost JF, et al. Biochim Biophys Acta, 1999 Oct 28. PMID 10542327
  2. Phosphorylation State of ZFP24 Controls Oligodendrocyte Differentiation. Elbaz B, et al. Cell Rep, 2018 May 22. PMID 29791837, Free PMC Article
  3. Zinc finger protein 191 deficiency attenuates vascular smooth muscle cell proliferation, migration, and intimal hyperplasia after endovascular arterial injury. Lv L, et al. J Vasc Surg, 2014 Feb. PMID 23755975
  4. Resistance to lipopolysaccharide-induced endotoxic shock in heterozygous Zfp191 gene-knockout mice. Sun RL, et al. Genet Mol Res, 2011 Dec 8. PMID 22183946
  5. [Cloning, genomic organization and promoter activity of the mouse zinc finger protein gene ZF-12]. Li JZ, et al. Yi Chuan Xue Bao, 2003 Apr. PMID 12812053

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZFP24 binds to a consensus DNA sequence in proximity to genes important for oligodendrocyte differentiation.
    Title: Phosphorylation State of ZFP24 Controls Oligodendrocyte Differentiation.
  2. ZFP191 played an essential role in aggressive proliferation and migration of vascular smooth muscle cells, which in turn facilitated intimal hyperplasia.
    Title: Zinc finger protein 191 deficiency attenuates vascular smooth muscle cell proliferation, migration, and intimal hyperplasia after endovascular arterial injury.
  3. The loss of Zfp191 may suppress systemic inflammation by reducing these cytokine levels during lipopolysaccharide-induced endotoxic shock.
    Title: Resistance to lipopolysaccharide-induced endotoxic shock in heterozygous Zfp191 gene-knockout mice.
  4. this study demonstrates that ZFP191 is required for the myelinating function of differentiated oligodendrocytes.
    Title: ZFP191 is required by oligodendrocytes for CNS myelination.
  5. Data confirm ZNF191 as an essential factor acting for the promotion of the cell cycle and thus maintenance in the progenitor stage.
    Title: Zinc finger protein 191 (ZNF191/Zfp191) is necessary to maintain neural cells as cycling progenitors.
  6. the DNA-binding domain of Zfp191 can specifically bind to the TCAT repeat motif, and there is a cooperative effect among the target DNA's multiple binding sites
    Title: Characterization of the target DNA sequence for the DNA-binding domain of zinc finger protein 191.
  7. These data show that Zfp191 is indispensable for early embryonic development and cell proliferation.
    Title: The zinc finger transcription factor 191 is required for early embryonic development and cell proliferation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in myelination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
zinc finger protein 24
Names
hypomyelinated CNS protein
zfp-191
zinc finger protein 191
zinc finger protein ZF-12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357447.1 → NP_001344376.1  zinc finger protein 24

    Status: VALIDATED

    Source sequence(s)
    AC126807, BP764437
    Consensus CDS
    CCDS29098.1
    UniProtKB/Swiss-Prot
    Q5MDG8, Q91VN1, Q9WUQ0
    Conserved Domains (3) summary
    smart00431
    Location:48 → 159
    SCAN; leucine rich region
    COG5048
    Location:305 → 358
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:253 → 273
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001357448.1 → NP_001344377.1  zinc finger protein 24

    Status: VALIDATED

    Source sequence(s)
    AC126807, BP764437
    Consensus CDS
    CCDS29098.1
    UniProtKB/Swiss-Prot
    Q5MDG8, Q91VN1, Q9WUQ0
    Related
    ENSMUSP00000122579.2, ENSMUST00000153337.2
    Conserved Domains (3) summary
    smart00431
    Location:48 → 159
    SCAN; leucine rich region
    COG5048
    Location:305 → 358
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:253 → 273
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. NM_021559.3 → NP_067534.2  zinc finger protein 24

    See identical proteins and their annotated locations for NP_067534.2

    Status: VALIDATED

    Source sequence(s)
    AC126807, BC054832, BP764437, CD562306
    Consensus CDS
    CCDS29098.1
    UniProtKB/Swiss-Prot
    Q5MDG8, Q91VN1, Q9WUQ0
    Related
    ENSMUSP00000064637.6, ENSMUST00000066497.12
    Conserved Domains (3) summary
    smart00431
    Location:48 → 159
    SCAN; leucine rich region
    COG5048
    Location:305 → 358
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:253 → 273
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    24142774..24155294 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161225.1 → XP_036017118.1  zinc finger protein 24 isoform X1

    UniProtKB/Swiss-Prot
    Q5MDG8, Q91VN1, Q9WUQ0
    Conserved Domains (3) summary
    smart00431
    Location:48 → 159
    SCAN; leucine rich region
    COG5048
    Location:305 → 358
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:253 → 273
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. XM_036161226.1 → XP_036017119.1  zinc finger protein 24 isoform X1

    UniProtKB/Swiss-Prot
    Q5MDG8, Q91VN1, Q9WUQ0
    Conserved Domains (3) summary
    smart00431
    Location:48 → 159
    SCAN; leucine rich region
    COG5048
    Location:305 → 358
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:253 → 273
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91VN1.1 GenPept UniProtKB/Swiss-Prot:Q91VN1

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