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RHOU ras homolog family member U [ Homo sapiens (human) ]

Gene ID: 58480, updated on 21-Dec-2019

Summary

Official Symbol
RHOUprovided by HGNC
Official Full Name
ras homolog family member Uprovided by HGNC
Primary source
HGNC:HGNC:17794
See related
Ensembl:ENSG00000116574 MIM:606366
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARHU; G28K; WRCH1; hG28K; CDC42L1
Summary
This gene encodes a member of the Rho family of GTPases. This protein can activate PAK1 and JNK1, and can induce filopodium formation and stress fiber dissolution. It may also mediate the effects of WNT1 signaling in the regulation of cell morphology, cytoskeletal organization, and cell proliferation. A non-coding transcript variant of this gene results from naturally occurring read-through transcription between this locus and the neighboring DUSP5P (dual specificity phosphatase 5 pseudogene) locus.[provided by RefSeq, Mar 2011]
Expression
Ubiquitous expression in brain (RPKM 24.2), small intestine (RPKM 22.4) and 25 other tissues See more
Orthologs

Genomic context

See RHOU in Genome Data Viewer
Location:
1q42.13
Exon count:
4
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (228644647..228746669)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (228780394..228882416)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RNA, 5S ribosomal 15 Neighboring gene RNA, 5S ribosomal 16 Neighboring gene RNA, 5S ribosomal pseudogene 18 Neighboring gene dual specificity phosphatase 5 pseudogene 1 Neighboring gene RNA, 5S ribosomal 17 Neighboring gene ferritin heavy chain 1 pseudogene 2 Neighboring gene eukaryotic translation elongation factor 1 alpha 2 pseudogene Neighboring gene uncharacterized LOC105373143

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Common variants on 1p36 and 1q42 are associated with cutaneous basal cell carcinoma but not with melanoma or pigmentation traits.
NHGRI GWA Catalog
Genome-wide association scan of dental caries in the permanent dentition.
NHGRI GWA Catalog
Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India.
NHGRI GWA Catalog
Germline sequence variants in TGM3 and RGS22 confer risk of basal cell carcinoma.
NHGRI GWA Catalog
Linkage and association of successful aging to the 6q25 region in large Amish kindreds.
NHGRI GWA Catalog
Meta-analysis of genome-wide association scans for genetic susceptibility to endometriosis in Japanese population.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif downregulates the expression of ras homolog family member U (RHOU) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough RHOU

Included gene: DUSP5P1

Homology

Clone Names

  • FLJ10616, DJ646B12.2, fJ646B12.2

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
Cdc42 protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G1/S transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
Rac protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell projection assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
establishment or maintenance of cell polarity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of protein targeting to mitochondrion HMP PubMed 
regulation of actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cell shape IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cell shape IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
cell cortex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
focal adhesion IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
podosome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
rho-related GTP-binding protein RhoU
Names
2310026M05Rik
CDC42-like GTPase 1
GTP-binding protein SB128
GTP-binding protein like 1
Ryu GTPase
ras homolog gene family, member U
ras-like gene family member U
rho GTPase-like protein ARHU
wnt-1 responsive Cdc42 homolog 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021205.6NP_067028.1  rho-related GTP-binding protein RhoU

    See identical proteins and their annotated locations for NP_067028.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.
    Source sequence(s)
    AF211836, BC040076
    Consensus CDS
    CCDS1575.1
    UniProtKB/Swiss-Prot
    Q7L0Q8
    UniProtKB/TrEMBL
    A0A024R3Q7
    Related
    ENSP00000355652.3, ENST00000366691.4
    Conserved Domains (1) summary
    cd04130
    Location:50222
    Wrch_1; Wnt-1 responsive Cdc42 homolog (Wrch-1) is a Rho family GTPase similar to Cdc42

RNA

  1. NR_037962.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' exon, compared to variant 1. This variant is a readthrough transcript between the upstream non-coding SNHG3 locus DUSP5P (GeneID: 574029) and the downstream RHOU locus (GeneID: 58480). This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AL096776, AL713899, DA321957

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    228644647..228746669
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_018654708.1 Reference GRCh38.p13 PATCHES

    Range
    201808..323673
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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