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Rhou ras homolog family member U [ Mus musculus (house mouse) ]

Gene ID: 69581, updated on 26-Sep-2022

Summary

Official Symbol
Rhouprovided by MGI
Official Full Name
ras homolog family member Uprovided by MGI
Primary source
MGI:MGI:1916831
See related
Ensembl:ENSMUSG00000039960 AllianceGenome:MGI:1916831
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Arhu; G28K; WRCH1; mG28K; WRCH-1; CDC42L1; 2310026M05Rik
Summary
Enables GTPase activity. Acts upstream of or within several processes, including G1/S transition of mitotic cell cycle; Rac protein signal transduction; and regulation of cell shape. Predicted to be located in several cellular components, including Golgi apparatus; cell junction; and plasma membrane. Is expressed in several structures, including branchial pouch; cerebral cortex; ganglia; gut; and hair follicle. Orthologous to human RHOU (ras homolog family member U). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 19.8), liver adult (RPKM 15.0) and 27 other tissues See more
Orthologs
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Genomic context

See Rhou in Genome Data Viewer
Location:
8; 8 E1
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (124380668..124390619)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (123653929..123663880)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 19600 Neighboring gene predicted gene, 35930 Neighboring gene predicted gene, 35874 Neighboring gene predicted gene, 35995 Neighboring gene predicted gene, 39277

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
rho-related GTP-binding protein RhoU
Names
Ras-like protein member U
Wnt1 responsive Cdc42 homolog
ras homolog gene family, member U
rho GTPase-like protein ARHU
wnt-1 responsive Cdc42 homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133955.5NP_598716.1  rho-related GTP-binding protein RhoU

    See identical proteins and their annotated locations for NP_598716.1

    Status: VALIDATED

    Source sequence(s)
    AC140552
    Consensus CDS
    CCDS22762.1
    UniProtKB/Swiss-Prot
    Q9EQT3
    UniProtKB/TrEMBL
    A0A6P5Q2U9
    Related
    ENSMUSP00000038915.4, ENSMUST00000045487.4
    Conserved Domains (1) summary
    cd04130
    Location:53225
    Wrch_1; Wnt-1 responsive Cdc42 homolog (Wrch-1) is a Rho family GTPase similar to Cdc42

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    124380668..124390619
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)