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PTPN3 protein tyrosine phosphatase, non-receptor type 3 [ Homo sapiens (human) ]

Gene ID: 5774, updated on 30-Dec-2018

Summary

Official Symbol
PTPN3provided by HGNC
Official Full Name
protein tyrosine phosphatase, non-receptor type 3provided by HGNC
Primary source
HGNC:HGNC:9655
See related
Ensembl:ENSG00000070159 MIM:176877
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PTPH1; PTP-H1
Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
Expression
Broad expression in skin (RPKM 9.4), kidney (RPKM 7.8) and 21 other tissues See more
Orthologs

Genomic context

See PTPN3 in Genome Data Viewer
Location:
9q31.3
Exon count:
33
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 9 NC_000009.12 (109375694..109538395, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (112137974..112260593, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene erythrocyte membrane protein band 4.1 like 4B Neighboring gene uncharacterized LOC107987113 Neighboring gene MT-ND2 pseudogene 11 Neighboring gene HNF1 motif-containing MPRA enhancer 98 Neighboring gene microRNA 3927 Neighboring gene Y-box binding protein 1 pseudogene 6 Neighboring gene paralemmin 2 Neighboring gene putative uncharacterized protein DDB_G0287265 Neighboring gene PALM2-AKAP2 readthrough Neighboring gene ribosomal protein L21 pseudogene 87

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • EGFR downregulation, organism-specific biosystem (from REACTOME)
    EGFR downregulation, organism-specific biosystemRegulation of receptor tyrosine kinase (RTK) activity is implicated in the control of almost all cellular functions. One of the best understood RTKs is epidermal growth factor receptor (EGFR). Growth...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by EGFR, organism-specific biosystem (from REACTOME)
    Signaling by EGFR, organism-specific biosystemThe epidermal growth factor receptor (EGFR) is one member of the ERBB family of transmembrane glycoprotein tyrosine receptor kinases (RTK). Binding of EGFR to its ligands induces conformational chang...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp686N0569

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
cytoskeletal protein binding IEA
Inferred from Electronic Annotation
more info
 
phosphotyrosine residue binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein tyrosine phosphatase activity TAS
Traceable Author Statement
more info
 
sodium channel regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
tyrosine-protein phosphatase non-receptor type 3
Names
cytoskeletal-associated protein tyrosine phosphatase
protein-tyrosine phosphatase H1
NP_001138840.1
NP_001138841.1
NP_001138842.1
NP_001138843.1
NP_001138844.1
NP_002820.3
XP_006717260.1
XP_006717262.1
XP_006717264.1
XP_006717265.1
XP_006717266.1
XP_006717267.1
XP_011517190.1
XP_011517191.1
XP_016870444.1
XP_016870445.1
XP_016870446.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047071.1 RefSeqGene

    Range
    45041..167660
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001145368.1NP_001138840.1  tyrosine-protein phosphatase non-receptor type 3 isoform 2

    See identical proteins and their annotated locations for NP_001138840.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is missing an in-frame coding exon compared to transcript variant 1, resulting in a shorter isoform (2) lacking an internal protein segment compared to isoform 1.
    Source sequence(s)
    AK096975, AK316066, AL359963, BC033716, BC126117, BU624870, DB173093
    UniProtKB/Swiss-Prot
    P26045
    UniProtKB/TrEMBL
    B7Z9V1, Q8N4S3
    Conserved Domains (7) summary
    smart00194
    Location:604855
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00295
    Location:31222
    B41; Band 4.1 homologues
    cd00047
    Location:627854
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00992
    Location:463550
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13189
    Location:216309
    FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
    pfam00373
    Location:115222
    FERM_M; FERM central domain
    pfam09379
    Location:3396
    FERM_N; FERM N-terminal domain
  2. NM_001145369.1NP_001138841.1  tyrosine-protein phosphatase non-receptor type 3 isoform 3

    See identical proteins and their annotated locations for NP_001138841.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, and initiates translation from an in-frame downstream AUG, resulting in an isoform (3) with a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AK096975, AL162733, AL359963, BU624870, BX648253, BX648735, DB173093, DB306298
    Consensus CDS
    CCDS48001.1
    UniProtKB/Swiss-Prot
    P26045
    Related
    ENSP00000416654.1, ENST00000412145.5
    Conserved Domains (6) summary
    smart00194
    Location:518769
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00295
    Location:291
    B41; Band 4.1 homologues
    cd00047
    Location:541768
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00992
    Location:377464
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13189
    Location:85178
    FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
    pfam00373
    Location:291
    FERM_M; FERM central domain
  3. NM_001145370.1NP_001138842.1  tyrosine-protein phosphatase non-receptor type 3 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, and is missing an in-frame coding exon compared to transcript variant 1, resulting in an isoform (4) with a shorter N-terminus and lacking an internal protein segment compared to isoform 1.
    Source sequence(s)
    AK096975, AL162733, AL359963, BU624870, BX648253, BX648735, DB173093, DB306298
    Consensus CDS
    CCDS48000.1
    UniProtKB/Swiss-Prot
    P26045
    Related
    ENSP00000395384.1, ENST00000446349.5
    Conserved Domains (6) summary
    smart00194
    Location:473724
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00295
    Location:291
    B41; Band 4.1 homologues
    cd00047
    Location:496723
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00992
    Location:332419
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13189
    Location:85178
    FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
    pfam00373
    Location:291
    FERM_M; FERM central domain
  4. NM_001145371.1NP_001138843.1  tyrosine-protein phosphatase non-receptor type 3 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, and initiates translation from an in-frame downstream AUG, resulting in an isoform (5) with a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AK096975, AK296388, AL359963, BC033716, BC126117, BU624870, DB173093, DC342461
    UniProtKB/Swiss-Prot
    P26045
    UniProtKB/TrEMBL
    B7Z3V3, Q8N4S3
    Conserved Domains (4) summary
    smart00194
    Location:362613
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:385612
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00992
    Location:221308
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl17171
    Location:122
    PH-like; Pleckstrin homology-like domain
  5. NM_001145372.1NP_001138844.1  tyrosine-protein phosphatase non-receptor type 3 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, and is missing an in-frame coding exon compared to transcript variant 1, resulting in an isoform (6) with a shorter N-terminus and lacking an internal protein segment compared to isoform 1.
    Source sequence(s)
    AK096975, AK316118, AL359963, BC033716, BU624870, DB173093, DC342461
    UniProtKB/TrEMBL
    B7ZA03, Q8N4S3
    Conserved Domains (4) summary
    smart00194
    Location:317568
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:340567
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00992
    Location:176263
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl17171
    Location:122
    PH-like; Pleckstrin homology-like domain
  6. NM_002829.4NP_002820.3  tyrosine-protein phosphatase non-receptor type 3 isoform 1

    See identical proteins and their annotated locations for NP_002820.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK096975, AK316066, AL359963, BC033716, BC126117, DB173093
    Consensus CDS
    CCDS6776.1
    UniProtKB/Swiss-Prot
    P26045
    UniProtKB/TrEMBL
    B7Z9V1, Q8N4S3
    Related
    ENSP00000363667.1, ENST00000374541.3
    Conserved Domains (4) summary
    smart00295
    Location:31222
    B41; Band 4.1 homologues
    cd00047
    Location:672899
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00992
    Location:508595
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13189
    Location:216309
    FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)

RNA

  1. NR_026918.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) contains an alternate 5' terminal exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK096975, AK303608, AL359963, BC033716, BU624870, DB173093

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p12 Primary Assembly

    Range
    109375694..109538395 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011518888.2XP_011517190.1  tyrosine-protein phosphatase non-receptor type 3 isoform X1

    Conserved Domains (7) summary
    smart00194
    Location:670921
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00295
    Location:52243
    B41; Band 4.1 homologues
    cd00047
    Location:693920
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00992
    Location:529616
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13189
    Location:237330
    FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
    pfam00373
    Location:136243
    FERM_M; FERM central domain
    pfam09379
    Location:54117
    FERM_N; FERM N-terminal domain
  2. XM_011518889.2XP_011517191.1  tyrosine-protein phosphatase non-receptor type 3 isoform X3

    See identical proteins and their annotated locations for XP_011517191.1

    UniProtKB/Swiss-Prot
    P26045
    Conserved Domains (4) summary
    smart00295
    Location:31222
    B41; Band 4.1 homologues
    cd00047
    Location:672899
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00992
    Location:508595
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13189
    Location:216309
    FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
  3. XM_017014956.1XP_016870445.1  tyrosine-protein phosphatase non-receptor type 3 isoform X7

  4. XM_006717201.3XP_006717264.1  tyrosine-protein phosphatase non-receptor type 3 isoform X4

    Conserved Domains (6) summary
    smart00194
    Location:540791
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00295
    Location:9113
    B41; Band 4.1 homologues
    cd00047
    Location:563790
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00992
    Location:399486
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13189
    Location:107200
    FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
    pfam00373
    Location:9113
    FERM_M; FERM central domain
  5. XM_017014957.1XP_016870446.1  tyrosine-protein phosphatase non-receptor type 3 isoform X8

    UniProtKB/Swiss-Prot
    P26045
    Conserved Domains (6) summary
    smart00194
    Location:473724
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00295
    Location:291
    B41; Band 4.1 homologues
    cd00047
    Location:496723
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00992
    Location:332419
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13189
    Location:85178
    FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
    pfam00373
    Location:291
    FERM_M; FERM central domain
  6. XM_006717204.3XP_006717267.1  tyrosine-protein phosphatase non-receptor type 3 isoform X6

    See identical proteins and their annotated locations for XP_006717267.1

    UniProtKB/Swiss-Prot
    P26045
    Conserved Domains (6) summary
    smart00194
    Location:518769
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00295
    Location:291
    B41; Band 4.1 homologues
    cd00047
    Location:541768
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00992
    Location:377464
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13189
    Location:85178
    FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
    pfam00373
    Location:291
    FERM_M; FERM central domain
  7. XM_006717199.3XP_006717262.1  tyrosine-protein phosphatase non-receptor type 3 isoform X3

    See identical proteins and their annotated locations for XP_006717262.1

    UniProtKB/Swiss-Prot
    P26045
    Conserved Domains (4) summary
    smart00295
    Location:31222
    B41; Band 4.1 homologues
    cd00047
    Location:672899
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00992
    Location:508595
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13189
    Location:216309
    FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
  8. XM_017014955.1XP_016870444.1  tyrosine-protein phosphatase non-receptor type 3 isoform X3

    UniProtKB/Swiss-Prot
    P26045
    Conserved Domains (4) summary
    smart00295
    Location:31222
    B41; Band 4.1 homologues
    cd00047
    Location:672899
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00992
    Location:508595
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13189
    Location:216309
    FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
  9. XM_006717197.3XP_006717260.1  tyrosine-protein phosphatase non-receptor type 3 isoform X2

    Conserved Domains (7) summary
    smart00194
    Location:660911
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00295
    Location:42233
    B41; Band 4.1 homologues
    cd00047
    Location:683910
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00992
    Location:519606
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13189
    Location:227320
    FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
    pfam00373
    Location:126233
    FERM_M; FERM central domain
    pfam09379
    Location:44107
    FERM_N; FERM N-terminal domain
  10. XM_006717202.3XP_006717265.1  tyrosine-protein phosphatase non-receptor type 3 isoform X5

    See identical proteins and their annotated locations for XP_006717265.1

    Conserved Domains (6) summary
    smart00194
    Location:534785
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00295
    Location:6107
    B41; Band 4.1 homologues
    cd00047
    Location:557784
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00992
    Location:393480
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13189
    Location:101194
    FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
    pfam00373
    Location:8107
    FERM_M; FERM central domain
  11. XM_006717203.4XP_006717266.1  tyrosine-protein phosphatase non-receptor type 3 isoform X5

    See identical proteins and their annotated locations for XP_006717266.1

    Conserved Domains (6) summary
    smart00194
    Location:534785
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00295
    Location:6107
    B41; Band 4.1 homologues
    cd00047
    Location:557784
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00992
    Location:393480
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13189
    Location:101194
    FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
    pfam00373
    Location:8107
    FERM_M; FERM central domain
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