Ptpn3 protein tyrosine phosphatase, non-receptor type 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ptpn3provided by MGI
Official Full Name: protein tyrosine phosphatase, non-receptor type 3provided by MGI
Primary source: MGI:MGI:105307
See related: Ensembl:ENSMUSG00000038764 AllianceGenome:MGI:105307
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PTPCL; PTP-H1; 9530011I20Rik
Summary: Predicted to enable several functions, including ATPase binding activity; phosphotyrosine residue binding activity; and sodium channel regulator activity. Predicted to be involved in several processes, including negative regulation of membrane protein ectodomain proteolysis; regulation of membrane depolarization during action potential; and regulation of sodium ion transmembrane transporter activity. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm and cytoplasmic side of plasma membrane. Is expressed in several structures, including cranial ganglion; gut; nasal epithelium; submandibular gland primordium; and urinary system. Orthologous to human PTPN3 (protein tyrosine phosphatase non-receptor type 3). [provided by Alliance of Genome Resources, Apr 2025]
Expression: Ubiquitous expression in bladder adult (RPKM 7.3), cortex adult (RPKM 5.5) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 B3; 4 31.66 cM

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (57190841..57339036, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (57190841..57339040, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

p38gamma Mitogen-activated protein kinase signals through phosphorylating its phosphatase PTPH1 in regulating ras protein oncogenesis and stress response.
Title: p38γ Mitogen-activated protein kinase signals through phosphorylating its phosphatase PTPH1 in regulating ras protein oncogenesis and stress response.
PTPN3 and PTPN4 are dispensable for TCR signal transduction.
Title: The FERM and PDZ domain-containing protein tyrosine phosphatases, PTPN4 and PTPN3, are both dispensable for T cell receptor signal transduction.
PTP-H1 has a role in modulating GHR signaling and systemic growth through insulin-like growth factor 1 secretion
Title: Protein-tyrosine phosphatase H1 controls growth hormone receptor signaling and systemic growth.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (4) 1 citation
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MHAa54e12.seq (e-PCR)
- UniSTS:125216

NoName (e-PCR)
- UniSTS:234926

NoName (e-PCR)
- UniSTS:493239

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATPase binding	IEA Inferred from Electronic Annotation more info
enables ATPase binding	ISO Inferred from Sequence Orthology more info
enables cytoskeletal protein binding	IEA Inferred from Electronic Annotation more info
enables histone H2AXY142 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphotyrosine residue binding	IEA Inferred from Electronic Annotation more info
enables phosphotyrosine residue binding	ISO Inferred from Sequence Orthology more info
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein tyrosine phosphatase activity, metal-dependent	IEA Inferred from Electronic Annotation more info
enables sodium channel regulator activity	IEA Inferred from Electronic Annotation more info
enables sodium channel regulator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in liver regeneration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of membrane protein ectodomain proteolysis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of membrane protein ectodomain proteolysis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mitotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in protein dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of membrane depolarization during action potential	IEA Inferred from Electronic Annotation more info
involved_in regulation of membrane depolarization during action potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of sodium ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasmic side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic side of plasma membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tyrosine-protein phosphatase non-receptor type 3

Names: protein-tyrosine phosphatase H1

NP_001371044.1

EC 3.1.3.48

NP_035337.2

EC 3.1.3.48

XP_006538160.1

EC 3.1.3.48

XP_006538162.1

EC 3.1.3.48

XP_006538163.1

EC 3.1.3.48

XP_006538164.1

EC 3.1.3.48

XP_036020143.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001384115.1 → NP_001371044.1 tyrosine-protein phosphatase non-receptor type 3

Status: VALIDATED

Source sequence(s)

AL805921

UniProtKB/Swiss-Prot

A2ALK8

Conserved Domains (4) summary

smart00295
Location:31 → 222

B41; Band 4.1 homologues

cd00992
Location:508 → 595

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13189
Location:216 → 309

FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)

cd14600
Location:631 → 904

PTPc-N3; catalytic domain of tyrosine-protein phosphatase non-receptor type 3
NM_011207.2 → NP_035337.2 tyrosine-protein phosphatase non-receptor type 3

See identical proteins and their annotated locations for NP_035337.2

Status: VALIDATED

Source sequence(s)

AL805921

Consensus CDS

CCDS51181.1

UniProtKB/Swiss-Prot

A2ALK8

Related

ENSMUSP00000075063.5, ENSMUST00000075637.11

Conserved Domains (4) summary

smart00295
Location:31 → 222

B41; Band 4.1 homologues

cd00992
Location:508 → 595

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13189
Location:216 → 309

FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)

cd14600
Location:631 → 904

PTPc-N3; catalytic domain of tyrosine-protein phosphatase non-receptor type 3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

57190841..57339036 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006538097.5 → XP_006538160.1 tyrosine-protein phosphatase non-receptor type 3 isoform X1

Conserved Domains (4) summary

smart00295
Location:53 → 244

B41; Band 4.1 homologues

cd00992
Location:530 → 617

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13189
Location:238 → 331

FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)

cd14600
Location:653 → 926

PTPc-N3; catalytic domain of tyrosine-protein phosphatase non-receptor type 3
XM_006538100.4 → XP_006538163.1 tyrosine-protein phosphatase non-receptor type 3 isoform X2

See identical proteins and their annotated locations for XP_006538163.1

UniProtKB/Swiss-Prot

A2ALK8

Conserved Domains (4) summary

smart00295
Location:31 → 222

B41; Band 4.1 homologues

cd00992
Location:508 → 595

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13189
Location:216 → 309

FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)

cd14600
Location:631 → 904

PTPc-N3; catalytic domain of tyrosine-protein phosphatase non-receptor type 3
XM_036164250.1 → XP_036020143.1 tyrosine-protein phosphatase non-receptor type 3 isoform X4

Conserved Domains (3) summary

cd00992
Location:276 → 363

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd14600
Location:399 → 672

PTPc-N3; catalytic domain of tyrosine-protein phosphatase non-receptor type 3

cl17171
Location:1 → 77

PH-like; Pleckstrin homology-like domain
XM_006538099.4 → XP_006538162.1 tyrosine-protein phosphatase non-receptor type 3 isoform X2

See identical proteins and their annotated locations for XP_006538162.1

UniProtKB/Swiss-Prot

A2ALK8

Conserved Domains (4) summary

smart00295
Location:31 → 222

B41; Band 4.1 homologues

cd00992
Location:508 → 595

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13189
Location:216 → 309

FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)

cd14600
Location:631 → 904

PTPc-N3; catalytic domain of tyrosine-protein phosphatase non-receptor type 3
XM_006538101.4 → XP_006538164.1 tyrosine-protein phosphatase non-receptor type 3 isoform X3

Conserved Domains (4) summary

smart00295
Location:2 → 91

B41; Band 4.1 homologues

cd00992
Location:377 → 464

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13189
Location:85 → 178

FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)

cd14600
Location:500 → 773

PTPc-N3; catalytic domain of tyrosine-protein phosphatase non-receptor type 3