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Ptpn3 protein tyrosine phosphatase, non-receptor type 3 [ Mus musculus (house mouse) ]

Gene ID: 545622, updated on 26-Sep-2022

Summary

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Official Symbol
Ptpn3provided by MGI
Official Full Name
protein tyrosine phosphatase, non-receptor type 3provided by MGI
Primary source
MGI:MGI:105307
See related
Ensembl:ENSMUSG00000038764 AllianceGenome:MGI:105307
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PTPCL; PTP-H1; 9530011I20Rik
Summary
Predicted to enable several functions, including ATPase binding activity; phosphotyrosine residue binding activity; and sodium channel regulator activity. Predicted to be involved in several processes, including negative regulation of membrane protein ectodomain proteolysis; protein dephosphorylation; and regulation of membrane depolarization during action potential. Predicted to be located in cytoskeleton and plasma membrane. Predicted to be active in cytoplasm and cytoplasmic side of plasma membrane. Is expressed in several structures, including alimentary system; cranial ganglion; nasal epithelium; urinary system; and vibrissa. Orthologous to human PTPN3 (protein tyrosine phosphatase non-receptor type 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 7.3), cortex adult (RPKM 5.5) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Ptpn3 in Genome Data Viewer
Location:
4 B3; 4 31.66 cM
Exon count:
31
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (57190841..57339036, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (57190841..57339040, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34802 Neighboring gene predicted gene 12530 Neighboring gene predicted gene 12536 Neighboring gene RIKEN cDNA 1700042G15 gene Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Normal TCR signal transduction in mice that lack catalytically active PTPN3 protein tyrosine phosphatase. Bauler TJ, et al. J Immunol, 2007 Mar 15. PMID 17339465
  2. Protein phosphatases: structures and implications. Jia Z. Biochem Cell Biol, 1997. PMID 9192069
  3. Dynamic changes in gene expression during in vitro differentiation of mouse embryonic stem cells. Messerle M, et al. Cytokines Mol Ther, 1995 Jun. PMID 9384671
  4. The FERM and PDZ domain-containing protein tyrosine phosphatases, PTPN4 and PTPN3, are both dispensable for T cell receptor signal transduction. Bauler TJ, et al. PLoS One, 2008. PMID 19107198, Free PMC Article
  5. p38γ Mitogen-activated protein kinase signals through phosphorylating its phosphatase PTPH1 in regulating ras protein oncogenesis and stress response. Hou S, et al. J Biol Chem, 2012 Aug 10. PMID 22730326, Free PMC Article

See all (25) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. p38gamma Mitogen-activated protein kinase signals through phosphorylating its phosphatase PTPH1 in regulating ras protein oncogenesis and stress response.
    Title: p38γ Mitogen-activated protein kinase signals through phosphorylating its phosphatase PTPH1 in regulating ras protein oncogenesis and stress response.
  2. PTPN3 and PTPN4 are dispensable for TCR signal transduction.
    Title: The FERM and PDZ domain-containing protein tyrosine phosphatases, PTPN4 and PTPN3, are both dispensable for T cell receptor signal transduction.
  3. PTP-H1 has a role in modulating GHR signaling and systemic growth through insulin-like growth factor 1 secretion
    Title: Protein-tyrosine phosphatase H1 controls growth hormone receptor signaling and systemic growth.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATPase binding ISO
Inferred from Sequence Orthology
more info
  
enables cytoskeletal protein binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphotyrosine residue binding ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables sodium channel regulator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of membrane protein ectodomain proteolysis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of membrane depolarization during action potential ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of sodium ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tyrosine-protein phosphatase non-receptor type 3
Names
protein-tyrosine phosphatase H1
NP_001371044.1
NP_035337.2
XP_006538160.1
XP_006538162.1
XP_006538163.1
XP_006538164.1
XP_036020143.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001384115.1 → NP_001371044.1  tyrosine-protein phosphatase non-receptor type 3

    Status: VALIDATED

    Source sequence(s)
    AL805921
    UniProtKB/Swiss-Prot
    A2ALK8
    Conserved Domains (4) summary
    smart00295
    Location:31 → 222
    B41; Band 4.1 homologues
    cd00992
    Location:508 → 595
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13189
    Location:216 → 309
    FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
    cd14600
    Location:631 → 904
    PTPc-N3; catalytic domain of tyrosine-protein phosphatase non-receptor type 3

  2. NM_011207.2 → NP_035337.2  tyrosine-protein phosphatase non-receptor type 3

    See identical proteins and their annotated locations for NP_035337.2

    Status: VALIDATED

    Source sequence(s)
    AL805921
    Consensus CDS
    CCDS51181.1
    UniProtKB/Swiss-Prot
    A2ALK8
    Related
    ENSMUSP00000075063.5, ENSMUST00000075637.11
    Conserved Domains (4) summary
    smart00295
    Location:31 → 222
    B41; Band 4.1 homologues
    cd00992
    Location:508 → 595
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13189
    Location:216 → 309
    FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
    cd14600
    Location:631 → 904
    PTPc-N3; catalytic domain of tyrosine-protein phosphatase non-receptor type 3

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    57190841..57339036 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006538097.5 → XP_006538160.1  tyrosine-protein phosphatase non-receptor type 3 isoform X1

    Conserved Domains (4) summary
    smart00295
    Location:53 → 244
    B41; Band 4.1 homologues
    cd00992
    Location:530 → 617
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13189
    Location:238 → 331
    FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
    cd14600
    Location:653 → 926
    PTPc-N3; catalytic domain of tyrosine-protein phosphatase non-receptor type 3

  2. XM_006538100.4 → XP_006538163.1  tyrosine-protein phosphatase non-receptor type 3 isoform X2

    See identical proteins and their annotated locations for XP_006538163.1

    UniProtKB/Swiss-Prot
    A2ALK8
    Conserved Domains (4) summary
    smart00295
    Location:31 → 222
    B41; Band 4.1 homologues
    cd00992
    Location:508 → 595
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13189
    Location:216 → 309
    FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
    cd14600
    Location:631 → 904
    PTPc-N3; catalytic domain of tyrosine-protein phosphatase non-receptor type 3

  3. XM_036164250.1 → XP_036020143.1  tyrosine-protein phosphatase non-receptor type 3 isoform X4

    Conserved Domains (3) summary
    cd00992
    Location:276 → 363
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd14600
    Location:399 → 672
    PTPc-N3; catalytic domain of tyrosine-protein phosphatase non-receptor type 3
    cl17171
    Location:1 → 77
    PH-like; Pleckstrin homology-like domain

  4. XM_006538099.4 → XP_006538162.1  tyrosine-protein phosphatase non-receptor type 3 isoform X2

    See identical proteins and their annotated locations for XP_006538162.1

    UniProtKB/Swiss-Prot
    A2ALK8
    Conserved Domains (4) summary
    smart00295
    Location:31 → 222
    B41; Band 4.1 homologues
    cd00992
    Location:508 → 595
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13189
    Location:216 → 309
    FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
    cd14600
    Location:631 → 904
    PTPc-N3; catalytic domain of tyrosine-protein phosphatase non-receptor type 3

  5. XM_006538101.4 → XP_006538164.1  tyrosine-protein phosphatase non-receptor type 3 isoform X3

    Conserved Domains (4) summary
    smart00295
    Location:2 → 91
    B41; Band 4.1 homologues
    cd00992
    Location:377 → 464
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13189
    Location:85 → 178
    FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
    cd14600
    Location:500 → 773
    PTPc-N3; catalytic domain of tyrosine-protein phosphatase non-receptor type 3
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2ALK8.1 GenPept UniProtKB/Swiss-Prot:A2ALK8

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