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LRRN1 leucine rich repeat neuronal 1 [ Homo sapiens (human) ]

Gene ID: 57633, updated on 21-Dec-2019

Summary

Official Symbol
LRRN1provided by HGNC
Official Full Name
leucine rich repeat neuronal 1provided by HGNC
Primary source
HGNC:HGNC:20980
See related
Ensembl:ENSG00000175928
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NLRR-1; FIGLER3
Expression
Biased expression in brain (RPKM 12.5), testis (RPKM 4.5) and 8 other tissues See more
Orthologs

Genomic context

See LRRN1 in Genome Data Viewer
Location:
3p26.2
Exon count:
3
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (3799431..3849834)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (3841121..3889708)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene interleukin 5 receptor subunit alpha Neighboring gene tRNA nucleotidyl transferase 1 Neighboring gene cereblon Neighboring gene uncharacterized LOC100130207 Neighboring gene uncharacterized LOC107986007 Neighboring gene uncharacterized LOC102723512 Neighboring gene polyribonucleotide nucleotidyltransferase 1 pseudogene 1 Neighboring gene sulfatase modifying factor 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1497

Gene Ontology Provided by GOA

Process Evidence Code Pubs
positive regulation of synapse assembly IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
leucine-rich repeat neuronal protein 1
Names
fibronectin type III, immunoglobulin and leucine rich repeat domains 3
neuronal leucine-rich repeat protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001324188.2NP_001311117.1  leucine-rich repeat neuronal protein 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC023484, BC012463
    Consensus CDS
    CCDS33685.1
    UniProtKB/Swiss-Prot
    Q6UXK5
    Conserved Domains (8) summary
    smart00082
    Location:371419
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:13273
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam07679
    Location:429516
    I-set; Immunoglobulin I-set domain
    sd00031
    Location:339362
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:97120
    LRR_RI; leucine-rich repeat [structural motif]
    pfam00041
    Location:531600
    fn3; Fibronectin type III domain
    pfam13855
    Location:119179
    LRR_8; Leucine rich repeat
    cl11960
    Location:431516
    Ig; Immunoglobulin domain
  2. NM_001324189.2NP_001311118.1  leucine-rich repeat neuronal protein 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC023484, BC012463
    Consensus CDS
    CCDS33685.1
    UniProtKB/Swiss-Prot
    Q6UXK5
    Conserved Domains (8) summary
    smart00082
    Location:371419
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:13273
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam07679
    Location:429516
    I-set; Immunoglobulin I-set domain
    sd00031
    Location:339362
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:97120
    LRR_RI; leucine-rich repeat [structural motif]
    pfam00041
    Location:531600
    fn3; Fibronectin type III domain
    pfam13855
    Location:119179
    LRR_8; Leucine rich repeat
    cl11960
    Location:431516
    Ig; Immunoglobulin domain
  3. NM_020873.7NP_065924.3  leucine-rich repeat neuronal protein 1 precursor

    See identical proteins and their annotated locations for NP_065924.3

    Status: VALIDATED

    Description
    Transcript Variant: Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC023484, AK291717, AU154359, BC012463, BC034947, BU685265, CX867219, DA736067
    Consensus CDS
    CCDS33685.1
    UniProtKB/Swiss-Prot
    Q6UXK5
    UniProtKB/TrEMBL
    A8K6Q2
    Related
    ENSP00000314901.3, ENST00000319331.4
    Conserved Domains (8) summary
    smart00082
    Location:371419
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:13273
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam07679
    Location:429516
    I-set; Immunoglobulin I-set domain
    sd00031
    Location:339362
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:97120
    LRR_RI; leucine-rich repeat [structural motif]
    pfam00041
    Location:531600
    fn3; Fibronectin type III domain
    pfam13855
    Location:119179
    LRR_8; Leucine rich repeat
    cl11960
    Location:431516
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    3799431..3849834
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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