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ZBTB2 zinc finger and BTB domain containing 2 [ Homo sapiens (human) ]

Gene ID: 57621, updated on 1-Jun-2020

Summary

Official Symbol
ZBTB2provided by HGNC
Official Full Name
zinc finger and BTB domain containing 2provided by HGNC
Primary source
HGNC:HGNC:20868
See related
Ensembl:ENSG00000181472 MIM:616595
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF437
Expression
Ubiquitous expression in thyroid (RPKM 17.1), lymph node (RPKM 6.4) and 25 other tissues See more
Orthologs

Genomic context

See ZBTB2 in Genome Data Viewer
Location:
6q25.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (151364115..151391705, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (151685250..151712677, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene A-kinase anchoring protein 12 Neighboring gene RNY4 pseudogene 20 Neighboring gene RN7SK pseudogene 268 Neighboring gene heat shock protein family A (Hsp70) member 8 pseudogene 15 Neighboring gene required for meiotic nuclear division 1 homolog Neighboring gene acidic residue methyltransferase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study identifies novel loci associated with susceptibility to chronic myeloid leukemia.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of zinc finger and BTB domain containing 2 (ZBTB2) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger and BTB domain-containing protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020861.3NP_065912.1  zinc finger and BTB domain-containing protein 2

    See identical proteins and their annotated locations for NP_065912.1

    Status: VALIDATED

    Source sequence(s)
    AK291942, BC020172
    Consensus CDS
    CCDS5231.1
    UniProtKB/Swiss-Prot
    Q8N680
    Related
    ENSP00000323183.4, ENST00000325144.5
    Conserved Domains (4) summary
    sd00017
    Location:365385
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:363385
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:1484
    BTB; BTB/POZ domain
    pfam13465
    Location:377399
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    151364115..151391705 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017011137.1XP_016866626.1  zinc finger and BTB domain-containing protein 2 isoform X2

    Conserved Domains (3) summary
    sd00017
    Location:286306
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:284306
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:298320
    zf-H2C2_2; Zinc-finger double domain
  2. XM_005267076.3XP_005267133.1  zinc finger and BTB domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_005267133.1

    UniProtKB/Swiss-Prot
    Q8N680
    Conserved Domains (4) summary
    sd00017
    Location:365385
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:363385
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:1484
    BTB; BTB/POZ domain
    pfam13465
    Location:377399
    zf-H2C2_2; Zinc-finger double domain
  3. XM_011536004.2XP_011534306.1  zinc finger and BTB domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011534306.1

    UniProtKB/Swiss-Prot
    Q8N680
    Conserved Domains (4) summary
    sd00017
    Location:365385
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:363385
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:1484
    BTB; BTB/POZ domain
    pfam13465
    Location:377399
    zf-H2C2_2; Zinc-finger double domain
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