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ZNF687 zinc finger protein 687 [ Homo sapiens (human) ]

Gene ID: 57592, updated on 17-Sep-2022

Summary

Official Symbol
ZNF687provided by HGNC
Official Full Name
zinc finger protein 687provided by HGNC
Primary source
HGNC:HGNC:29277
See related
Ensembl:ENSG00000143373 MIM:610568; AllianceGenome:HGNC:29277
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PDB6
Summary
This gene encodes C2H2 zinc finger protein. The encoded protein may play a role in bone differentiation and development. Mutations in this gene are the cause of Paget disease of bone-6. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
Expression
Ubiquitous expression in bone marrow (RPKM 9.1), testis (RPKM 7.2) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF687 in Genome Data Viewer
Location:
1q21.3
Exon count:
13
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (151281522..151292176)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (150405216..150415869)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (151253998..151264652)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904419 Neighboring gene phosphatidylinositol-4-phosphate 5-kinase type 1 alpha Neighboring gene Sharpr-MPRA regulatory region 10214 Neighboring gene proteasome 26S subunit ubiquitin receptor, non-ATPase 4 Neighboring gene ZNF687 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 291 Neighboring gene phosphatidylinositol 4-kinase beta Neighboring gene RNA, 7SL, cytoplasmic 444, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat 47-59 peptide downregulates gene expression of zinc finger protein 687 (ZNF687) in U-937 macrophages PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1441, DKFZp781I1719

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051575.1 RefSeqGene

    Range
    5745..15622
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001304763.2NP_001291692.1  zinc finger protein 687

    See identical proteins and their annotated locations for NP_001291692.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest transcript. All three variants encode the same protein.
    Source sequence(s)
    AB037862, AL391069, CR749307
    Consensus CDS
    CCDS992.1
    UniProtKB/Swiss-Prot
    Q8N1G0, Q9P2A7
    Related
    ENSP00000319829.5, ENST00000324048.9
    Conserved Domains (3) summary
    sd00017
    Location:965985
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam15909
    Location:795877
    zf-C2H2_8; C2H2-type zinc ribbon
    pfam16622
    Location:11311159
    zf-C2H2_11; zinc-finger C2H2-type
  2. NM_001304764.2NP_001291693.1  zinc finger protein 687

    See identical proteins and their annotated locations for NP_001291693.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AL391069, BC032463, CR749307
    Consensus CDS
    CCDS992.1
    UniProtKB/Swiss-Prot
    Q8N1G0, Q9P2A7
    Conserved Domains (3) summary
    sd00017
    Location:965985
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam15909
    Location:795877
    zf-C2H2_8; C2H2-type zinc ribbon
    pfam16622
    Location:11311159
    zf-C2H2_11; zinc-finger C2H2-type
  3. NM_020832.3NP_065883.1  zinc finger protein 687

    See identical proteins and their annotated locations for NP_065883.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AB037862, AL391069, BC032463, CR749307
    Consensus CDS
    CCDS992.1
    UniProtKB/Swiss-Prot
    Q8N1G0, Q9P2A7
    Related
    ENSP00000336620.5, ENST00000336715.11
    Conserved Domains (3) summary
    sd00017
    Location:965985
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam15909
    Location:795877
    zf-C2H2_8; C2H2-type zinc ribbon
    pfam16622
    Location:11311159
    zf-C2H2_11; zinc-finger C2H2-type

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    151281522..151292176
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005245366.5XP_005245423.1  zinc finger protein 687 isoform X2

    Conserved Domains (3) summary
    sd00017
    Location:974994
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam15909
    Location:804886
    zf-C2H2_8; C2H2-type zinc ribbon
    pfam16622
    Location:11401168
    zf-C2H2_11; zinc-finger C2H2-type
  2. XM_047426167.1XP_047282123.1  zinc finger protein 687 isoform X5

  3. XM_047426163.1XP_047282119.1  zinc finger protein 687 isoform X3

    UniProtKB/Swiss-Prot
    Q9P2A7
  4. XM_011509812.3XP_011508114.1  zinc finger protein 687 isoform X3

    See identical proteins and their annotated locations for XP_011508114.1

    UniProtKB/Swiss-Prot
    Q8N1G0, Q9P2A7
    Conserved Domains (3) summary
    sd00017
    Location:965985
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam15909
    Location:795877
    zf-C2H2_8; C2H2-type zinc ribbon
    pfam16622
    Location:11311159
    zf-C2H2_11; zinc-finger C2H2-type
  5. XM_047426164.1XP_047282120.1  zinc finger protein 687 isoform X3

    UniProtKB/Swiss-Prot
    Q9P2A7
  6. XM_011509813.3XP_011508115.1  zinc finger protein 687 isoform X3

    See identical proteins and their annotated locations for XP_011508115.1

    UniProtKB/Swiss-Prot
    Q8N1G0, Q9P2A7
    Conserved Domains (3) summary
    sd00017
    Location:965985
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam15909
    Location:795877
    zf-C2H2_8; C2H2-type zinc ribbon
    pfam16622
    Location:11311159
    zf-C2H2_11; zinc-finger C2H2-type
  7. XM_047426162.1XP_047282118.1  zinc finger protein 687 isoform X1

  8. XM_011509811.3XP_011508113.2  zinc finger protein 687 isoform X4

  9. XM_047426166.1XP_047282122.1  zinc finger protein 687 isoform X3

    UniProtKB/Swiss-Prot
    Q9P2A7
  10. XM_047426165.1XP_047282121.1  zinc finger protein 687 isoform X3

    UniProtKB/Swiss-Prot
    Q9P2A7

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    150405216..150415869
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)