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ZNF687 zinc finger protein 687 [ Homo sapiens (human) ]

Gene ID: 57592, updated on 2-Oct-2018

Summary

Official Symbol
ZNF687provided by HGNC
Official Full Name
zinc finger protein 687provided by HGNC
Primary source
HGNC:HGNC:29277
See related
Ensembl:ENSG00000143373 MIM:610568; Vega:OTTHUMG00000012347
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PDB6
Summary
This gene encodes C2H2 zinc finger protein. The encoded protein may play a role in bone differentiation and development. Mutations in this gene are the cause of Paget disease of bone-6. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
Expression
Ubiquitous expression in bone marrow (RPKM 9.1), testis (RPKM 7.2) and 25 other tissues See more
Orthologs

Genomic context

See ZNF687 in Genome Data Viewer
Location:
1q21.3
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (151281555..151291905)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (151254094..151264381)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-4-phosphate 5-kinase type 1 alpha Neighboring gene proteasome 26S subunit, non-ATPase 4 Neighboring gene ZNF687 antisense RNA 1 Neighboring gene phosphatidylinositol 4-kinase beta Neighboring gene RNA, 7SL, cytoplasmic 444, pseudogene Neighboring gene regulatory factor X5 Neighboring gene glioblastoma multiforme-associated transcript 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat 47-59 peptide downregulates gene expression of zinc finger protein 687 (ZNF687) in U-937 macrophages PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1441, DKFZp781I1719

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051575.1 RefSeqGene

    Range
    5001..15351
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001304763.1NP_001291692.1  zinc finger protein 687

    See identical proteins and their annotated locations for NP_001291692.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest transcript. All three variants encode the same protein.
    Source sequence(s)
    AB037862, AL391069, CR749307
    Consensus CDS
    CCDS992.1
    UniProtKB/Swiss-Prot
    Q8N1G0
    Related
    ENSP00000319829.5, OTTHUMP00000014280, ENST00000324048.9, OTTHUMT00000034398
    Conserved Domains (3) summary
    sd00017
    Location:965985
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam15909
    Location:795877
    zf-C2H2_8; C2H2-type zinc ribbon
    pfam16622
    Location:11311159
    zf-C2H2_11; zinc-finger C2H2-type
  2. NM_001304764.1NP_001291693.1  zinc finger protein 687

    See identical proteins and their annotated locations for NP_001291693.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    BC032463, CR749307
    Consensus CDS
    CCDS992.1
    UniProtKB/Swiss-Prot
    Q8N1G0
    Conserved Domains (3) summary
    sd00017
    Location:965985
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam15909
    Location:795877
    zf-C2H2_8; C2H2-type zinc ribbon
    pfam16622
    Location:11311159
    zf-C2H2_11; zinc-finger C2H2-type
  3. NM_020832.2NP_065883.1  zinc finger protein 687

    See identical proteins and their annotated locations for NP_065883.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AB037862, BC032463, CR749307
    Consensus CDS
    CCDS992.1
    UniProtKB/Swiss-Prot
    Q8N1G0
    Related
    ENSP00000336620.5, OTTHUMP00000014279, ENST00000336715.10, OTTHUMT00000034397
    Conserved Domains (3) summary
    sd00017
    Location:965985
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam15909
    Location:795877
    zf-C2H2_8; C2H2-type zinc ribbon
    pfam16622
    Location:11311159
    zf-C2H2_11; zinc-finger C2H2-type

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    151281555..151291905
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005245366.4XP_005245423.1  zinc finger protein 687 isoform X1

    Conserved Domains (3) summary
    sd00017
    Location:974994
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam15909
    Location:804886
    zf-C2H2_8; C2H2-type zinc ribbon
    pfam16622
    Location:11401168
    zf-C2H2_11; zinc-finger C2H2-type
  2. XM_011509813.2XP_011508115.1  zinc finger protein 687 isoform X2

    See identical proteins and their annotated locations for XP_011508115.1

    UniProtKB/Swiss-Prot
    Q8N1G0
    Conserved Domains (3) summary
    sd00017
    Location:965985
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam15909
    Location:795877
    zf-C2H2_8; C2H2-type zinc ribbon
    pfam16622
    Location:11311159
    zf-C2H2_11; zinc-finger C2H2-type
  3. XM_011509812.2XP_011508114.1  zinc finger protein 687 isoform X2

    See identical proteins and their annotated locations for XP_011508114.1

    UniProtKB/Swiss-Prot
    Q8N1G0
    Conserved Domains (3) summary
    sd00017
    Location:965985
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam15909
    Location:795877
    zf-C2H2_8; C2H2-type zinc ribbon
    pfam16622
    Location:11311159
    zf-C2H2_11; zinc-finger C2H2-type
  4. XM_011509811.2XP_011508113.1  zinc finger protein 687 isoform X3

    Conserved Domains (2) summary
    sd00017
    Location:906926
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam16622
    Location:10721100
    zf-C2H2_11; zinc-finger C2H2-type
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