U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

IGSF9 immunoglobulin superfamily member 9 [ Homo sapiens (human) ]

Gene ID: 57549, updated on 18-Oct-2022

Summary

Official Symbol
IGSF9provided by HGNC
Official Full Name
immunoglobulin superfamily member 9provided by HGNC
Primary source
HGNC:HGNC:18132
See related
Ensembl:ENSG00000085552 MIM:609738; AllianceGenome:HGNC:18132
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Nrt1; IGSF9A; FP18798
Summary
Predicted to enable cell-cell adhesion mediator activity. Predicted to be involved in axon guidance; dendrite self-avoidance; and homophilic cell adhesion via plasma membrane adhesion molecules. Predicted to act upstream of or within dendrite development and regulation of synapse organization. Predicted to be located in dendrite and inhibitory synapse. Predicted to be integral component of membrane. Predicted to be active in axon and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in skin (RPKM 12.2), stomach (RPKM 7.5) and 8 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See IGSF9 in Genome Data Viewer
Location:
1q23.2
Exon count:
21
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (159927041..159945613, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (159064110..159082679, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (159896831..159915403, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory regions 3039 and 8536 Neighboring gene uncharacterized LOC124904437 Neighboring gene transgelin 2 Neighboring gene uncharacterized LOC124904438 Neighboring gene Sharpr-MPRA regulatory region 11999 Neighboring gene SLAM family member 9 Neighboring gene long intergenic non-protein coding RNA 1133 Neighboring gene Fc receptor like 6 pseudogene 1 Neighboring gene uncharacterized LOC124904436 Neighboring gene ribosomal protein L27a pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • KIAA1355

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cell-cell adhesion mediator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in dendrite development IEA
Inferred from Electronic Annotation
more info
 
involved_in dendrite self-avoidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of synapse organization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
 
located_in inhibitory synapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
protein turtle homolog A
Names
immunoglobulin superfamily member 9A
turtle homolog A

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135050.2NP_001128522.1  protein turtle homolog A isoform a precursor

    See identical proteins and their annotated locations for NP_001128522.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AB037776, AI758999, AL513485, CK299326
    Consensus CDS
    CCDS44254.1
    UniProtKB/Swiss-Prot
    Q9P2J2
    Related
    ENSP00000357073.1, ENST00000368094.6
    Conserved Domains (7) summary
    cd00096
    Location:154220
    Ig; Immunoglobulin domain
    smart00410
    Location:233319
    IG_like; Immunoglobulin like
    cd00063
    Location:625715
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:136223
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:511596
    fn3; Fibronectin type III domain
    pfam13927
    Location:226305
    Ig_3; Immunoglobulin domain
    cl11960
    Location:341404
    Ig; Immunoglobulin domain
  2. NM_020789.4NP_065840.2  protein turtle homolog A isoform b precursor

    See identical proteins and their annotated locations for NP_065840.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AB037776, AI758999, AL513485, BC030141, CK299326
    Consensus CDS
    CCDS1190.1
    UniProtKB/Swiss-Prot
    Q9P2J2
    Related
    ENSP00000355049.3, ENST00000361509.7
    Conserved Domains (7) summary
    cd00096
    Location:154220
    Ig; Immunoglobulin domain
    smart00410
    Location:233319
    IG_like; Immunoglobulin like
    cd00063
    Location:609699
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:136223
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:495580
    fn3; Fibronectin type III domain
    pfam13927
    Location:226305
    Ig_3; Immunoglobulin domain
    cl11960
    Location:325388
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    159927041..159945613 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    159064110..159082679 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)