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Igsf9 immunoglobulin superfamily, member 9 [ Mus musculus (house mouse) ]

Gene ID: 93842, updated on 7-Aug-2026
Official Symbol
Igsf9provided by MGI
Official Full Name
immunoglobulin superfamily, member 9provided by MGI
Primary source
MGI:MGI:2135283
See related
Ensembl:ENSMUSG00000037995 AllianceGenome:MGI:2135283
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NRT1; Dasm1; Ncaml; igSF9A; 644ETD8; mKIAA1355; Kiaa1355-hp
Summary
Enables cell-cell adhesion mediator activity. Acts upstream of or within dendrite development; homophilic cell adhesion via plasma membrane adhesion molecules; and regulation of synapse organization. Located in axon; dendrite; and inhibitory synapse. Is expressed in several structures, including alimentary system; central nervous system; limb; sensory organ; and urinary system. Orthologous to human IGSF9 (immunoglobulin superfamily member 9). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in duodenum adult (RPKM 132.1), small intestine adult (RPKM 112.2) and 10 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See Igsf9 in Genome Data Viewer
Location:
1 H3; 1 79.86 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (172307616..172326444)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (172481573..172498877)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein SA pseudogene Neighboring gene SLAM family member 9 Neighboring gene STARR-positive B cell enhancer ABC_E4391 Neighboring gene transgelin 2 Neighboring gene STARR-positive B cell enhancer ABC_E2587 Neighboring gene STARR-positive B cell enhancer ABC_E9066 Neighboring gene STARR-seq mESC enhancer starr_03067 Neighboring gene STARR-positive B cell enhancer ABC_E7779 Neighboring gene cilia and flagella associated protein 45 Neighboring gene STARR-positive B cell enhancer mm9_chr1:174458799-174459099 Neighboring gene RIKEN cDNA 4933439K11 gene Neighboring gene STARR-seq mESC enhancer starr_03068

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The transgenic mouse line Igsf9-eGFP allows targeted stimulation of inferior olive efferents. Pätz C, et al. J Neurosci Methods, 2018 Feb 15. PMID 29291926
  2. Dasm1: a receptor that shapes neuronal dendrites and turns on silent synapses? Falls DL. Sci STKE, 2005 Mar 8. PMID 15755926
  3. Tumor-associated macrophages educated by IGSF9 exhibit a senescence-associated secretory phenotype to promote tumor immune escape. Zhang J, et al. J Immunother Cancer, 2026 Jan 14. PMID 41534903, Free PMC Article
  4. The immunoglobulin family member dendrite arborization and synapse maturation 1 (Dasm1) controls excitatory synapse maturation. Shi SH, et al. Proc Natl Acad Sci U S A, 2004 Sep 7. PMID 15340156, Free PMC Article
  5. Control of dendrite arborization by an Ig family member, dendrite arborization and synapse maturation 1 (Dasm1). Shi SH, et al. Proc Natl Acad Sci U S A, 2004 Sep 7. PMID 15340157, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MRCKbeta links Dasm1 to actin rearrangements to promote dendrite development.
    Title: MRCKβ links Dasm1 to actin rearrangements to promote dendrite development.
  2. These results provide genetic evidence for a specific role of IgSF9 in inhibitory synapse development/maintenance, presumably by its cell adhesion molecule-like activity.
    Title: Genetic evidence for the adhesion protein IgSF9/Dasm1 to regulate inhibitory synapse development independent of its intracellular domain.
  3. dendrite arborization phenotype was caused by off-target effects and that Dasm-1 is dispensable for hippocampal dendrite arborization
    Title: The protein dendrite arborization and synapse maturation 1 (Dasm-1) is dispensable for dendrite arborization.
  4. Review. Dasm1, a protein likely to function as a neuronal cell-surface receptor, plays an important role in both shaping the dendritic tree and affecting the fraction of electrically active glutamatergic synapses.
    Title: Dasm1: a receptor that shapes neuronal dendrites and turns on silent synapses?
Submit: New GeneRIF Correction

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Gene trapped (1) 
  • Targeted (3)  1 citation

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cell-cell adhesion mediator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within dendrite development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within homophilic cell-cell adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in homophilic cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of synapse maturation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of synapse maturation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of synapse organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of synapse organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in dendrite IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in inhibitory synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic density membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic density membrane ISO
Inferred from Sequence Orthology
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
protein turtle homolog A
Names
NCAM-like protein NRT1
dendrite arborization and synapse maturation protein 1
immunoglobulin superfamily member 9A

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145800.2 → NP_001139272.1  protein turtle homolog A precursor

    See identical proteins and their annotated locations for NP_001139272.1

    Status: VALIDATED

    Source sequence(s)
    AC121551
    Consensus CDS
    CCDS15515.1
    UniProtKB/Swiss-Prot
    Q05BQ1, Q8R1J8, Q925P4
    Related
    ENSMUSP00000058275.7, ENSMUST00000052629.14
    Conserved Domains (5) summary
    smart00410
    Location:28 → 110
    IG_like; Immunoglobulin like
    cd00063
    Location:625 → 715
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:436 → 500
    Ig; Immunoglobulin domain
    pfam13927
    Location:227 → 305
    Ig_3; Immunoglobulin domain
    cl11960
    Location:136 → 223
    Ig; Immunoglobulin domain

  2. NM_001443617.1 → NP_001430546.1  protein turtle homolog A precursor

    Status: VALIDATED

    Source sequence(s)
    AC121551
    UniProtKB/Swiss-Prot
    Q05BQ1, Q8R1J8, Q925P4

  3. NM_033608.4 → NP_291086.2  protein turtle homolog A precursor

    See identical proteins and their annotated locations for NP_291086.2

    Status: VALIDATED

    Source sequence(s)
    AC121551
    Consensus CDS
    CCDS15515.1
    UniProtKB/Swiss-Prot
    Q05BQ1, Q8R1J8, Q925P4
    Related
    ENSMUSP00000106866.3, ENSMUST00000111235.9
    Conserved Domains (5) summary
    smart00410
    Location:28 → 110
    IG_like; Immunoglobulin like
    cd00063
    Location:625 → 715
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:436 → 500
    Ig; Immunoglobulin domain
    pfam13927
    Location:227 → 305
    Ig_3; Immunoglobulin domain
    cl11960
    Location:136 → 223
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    172307616..172326444
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154500.1 → XP_036010393.1  protein turtle homolog A isoform X2

    Conserved Domains (6) summary
    smart00409
    Location:28 → 110
    IG; Immunoglobulin
    PHA03247
    Location:939 → 1128
    PHA03247; large tegument protein UL36; Provisional
    cd00063
    Location:625 → 715
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam13927
    Location:226 → 305
    Ig_3; Immunoglobulin domain
    cd00096
    Location:228 → 231
    Ig; Ig strand A [structural motif]
    cl11960
    Location:136 → 223
    Ig; Immunoglobulin domain

  2. XM_030243785.2 → XP_030099645.1  protein turtle homolog A isoform X1

    UniProtKB/Swiss-Prot
    Q05BQ1, Q8R1J8, Q925P4
    Conserved Domains (5) summary
    smart00410
    Location:28 → 110
    IG_like; Immunoglobulin like
    cd00063
    Location:625 → 715
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:436 → 500
    Ig; Immunoglobulin domain
    pfam13927
    Location:227 → 305
    Ig_3; Immunoglobulin domain
    cl11960
    Location:136 → 223
    Ig; Immunoglobulin domain

  3. XM_006497056.5 → XP_006497119.1  

    Conserved Domains (5) summary
    smart00410
    Location:28 → 110
    IG_like; Immunoglobulin like
    cd00063
    Location:625 → 715
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:436 → 500
    Ig; Immunoglobulin domain
    pfam13927
    Location:227 → 305
    Ig_3; Immunoglobulin domain
    cl11960
    Location:136 → 223
    Ig; Immunoglobulin domain

  4. XM_030243786.1 → XP_030099646.1  protein turtle homolog A isoform X3

    Related
    ENSMUSP00000306570.1, ENSMUST00000528207.1
    Conserved Domains (4) summary
    cd00063
    Location:562 → 652
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam13927
    Location:163 → 242
    Ig_3; Immunoglobulin domain
    cd00096
    Location:165 → 168
    Ig; Ig strand A [structural motif]
    cl11960
    Location:73 → 160
    Ig; Immunoglobulin domain

  5. XM_036154499.1 → XP_036010392.1  protein turtle homolog A isoform X2

    Conserved Domains (6) summary
    smart00409
    Location:28 → 110
    IG; Immunoglobulin
    PHA03247
    Location:939 → 1128
    PHA03247; large tegument protein UL36; Provisional
    cd00063
    Location:625 → 715
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam13927
    Location:226 → 305
    Ig_3; Immunoglobulin domain
    cd00096
    Location:228 → 231
    Ig; Ig strand A [structural motif]
    cl11960
    Location:136 → 223
    Ig; Immunoglobulin domain

  6. XM_006497057.2 → XP_006497120.1  protein turtle homolog A isoform X3

    Related
    ENSMUSP00000306572.1, ENSMUST00000528209.1
    Conserved Domains (4) summary
    cd00063
    Location:562 → 652
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam13927
    Location:163 → 242
    Ig_3; Immunoglobulin domain
    cd00096
    Location:165 → 168
    Ig; Ig strand A [structural motif]
    cl11960
    Location:73 → 160
    Ig; Immunoglobulin domain

  7. XM_036154506.1 → XP_036010399.1  protein turtle homolog A isoform X4

    Conserved Domains (4) summary
    cd00063
    Location:498 → 588
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam13927
    Location:99 → 178
    Ig_3; Immunoglobulin domain
    cd00096
    Location:101 → 104
    Ig; Ig strand A [structural motif]
    cl11960
    Location:9 → 96
    Ig; Immunoglobulin domain

  8. XM_036154505.1 → XP_036010398.1  protein turtle homolog A isoform X3

    Related
    ENSMUSP00000306577.1, ENSMUST00000528214.1
    Conserved Domains (4) summary
    cd00063
    Location:562 → 652
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam13927
    Location:163 → 242
    Ig_3; Immunoglobulin domain
    cd00096
    Location:165 → 168
    Ig; Ig strand A [structural motif]
    cl11960
    Location:73 → 160
    Ig; Immunoglobulin domain

RNA

  1. XR_004935294.1 RNA Sequence

  2. XR_004935295.1 RNA Sequence

  3. XR_004935292.1 RNA Sequence

  4. XR_004935291.1 RNA Sequence

    Related
    ENSMUST00000528213.1

  5. XR_004935296.1 RNA Sequence

    Related
    ENSMUST00000528211.1

  6. XR_004935293.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q05BQ1.2 GenPept UniProtKB/Swiss-Prot:Q05BQ1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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