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PTGER4 prostaglandin E receptor 4 [ Homo sapiens (human) ]

Gene ID: 5734, updated on 20-Sep-2020

Summary

Official Symbol
PTGER4provided by HGNC
Official Full Name
prostaglandin E receptor 4provided by HGNC
Primary source
HGNC:HGNC:9596
See related
Ensembl:ENSG00000171522 MIM:601586
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EP4; EP4R
Summary
The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses. [provided by RefSeq, Jul 2008]
Expression
Broad expression in bone marrow (RPKM 30.5), colon (RPKM 12.1) and 18 other tissues See more
Orthologs

Genomic context

See PTGER4 in Genome Data Viewer
Location:
5p13.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (40679915..40740936)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (40680032..40696962)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374736 Neighboring gene uncharacterized LOC105374737 Neighboring gene tetratricopeptide repeat domain 33 Neighboring gene HNF1 motif-containing MPRA enhancer 12 Neighboring gene CRISPRi-validated cis-regulatory element chr5.1161 Neighboring gene protein kinase AMP-activated catalytic subunit alpha 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
GeneReviews: Not available
A genome-wide association study identifies new susceptibility loci for non-cardia gastric cancer at 3q13.31 and 5p13.1.
GeneReviews: Not available
A genome-wide association study on a southern European population identifies a new Crohn's disease susceptibility locus at RBX1-EP300.
GeneReviews: Not available
A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
GeneReviews: Not available
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
GeneReviews: Not available
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
GeneReviews: Not available
Genome-wide association study of multiple sclerosis confirms a novel locus at 5p13.1.
GeneReviews: Not available
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
GeneReviews: Not available
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
GeneReviews: Not available
Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility.
GeneReviews: Not available
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
GeneReviews: Not available
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.
GeneReviews: Not available
Systematic association mapping identifies NELL1 as a novel IBD disease gene.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
capsid gag Prostaglandin E2 downregulates HIV-1 CA/p24 production through the EP2 and EP4 receptors PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126583

Gene Ontology Provided by GOA

Function Evidence Code Pubs
prostaglandin E receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
prostaglandin E receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
JNK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
T-helper cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adenylate cyclase-modulating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
bone development ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to mechanical stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to prostaglandin E stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
immune response IEP
Inferred from Expression Pattern
more info
PubMed 
inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of cytokine secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of eosinophil extravasation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of integrin activation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cytokine secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of ossification IEA
Inferred from Electronic Annotation
more info
 
regulation of stress fiber assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
prostaglandin E2 receptor EP4 subtype
Names
PGE receptor, EP4 subtype
PGE2 receptor EP4 subtype
prostaglandin E receptor 4 (subtype EP4)
prostanoid EP4 receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047000.1 RefSeqGene

    Range
    5418..19238
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000958.3NP_000949.1  prostaglandin E2 receptor EP4 subtype

    See identical proteins and their annotated locations for NP_000949.1

    Status: REVIEWED

    Source sequence(s)
    AC093264, BC027934, BM312677, BQ029720, CD000197, L28175
    Consensus CDS
    CCDS3930.1
    UniProtKB/Swiss-Prot
    P35408
    UniProtKB/TrEMBL
    A0PJF5
    Related
    ENSP00000302846.3, ENST00000302472.4
    Conserved Domains (1) summary
    cd15142
    Location:18341
    7tmA_PGE2_EP4; prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    40679915..40740936
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009659.2XP_016865148.1  prostaglandin E2 receptor EP4 subtype isoform X4

    Conserved Domains (2) summary
    pfam00001
    Location:34222
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:29216
    7tm_4; Olfactory receptor
  2. XM_017009656.2XP_016865145.1  prostaglandin E2 receptor EP4 subtype isoform X1

    Conserved Domains (2) summary
    pfam00001
    Location:34222
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:29216
    7tm_4; Olfactory receptor
  3. XM_017009657.1XP_016865146.1  prostaglandin E2 receptor EP4 subtype isoform X2

    Conserved Domains (2) summary
    pfam00001
    Location:34222
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:29216
    7tm_4; Olfactory receptor
  4. XM_017009658.1XP_016865147.1  prostaglandin E2 receptor EP4 subtype isoform X3

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