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Ptger4 prostaglandin E receptor 4 (subtype EP4) [ Mus musculus (house mouse) ]

Gene ID: 19219, updated on 11-Apr-2024

Summary

Official Symbol
Ptger4provided by MGI
Official Full Name
prostaglandin E receptor 4 (subtype EP4)provided by MGI
Primary source
MGI:MGI:104311
See related
Ensembl:ENSMUSG00000039942 AllianceGenome:MGI:104311
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EP4; Ptgerep4
Summary
Predicted to enable prostaglandin E receptor activity. Involved in several processes, including T-helper cell differentiation; regulation of cytokine production; and regulation of stress fiber assembly. Acts upstream of or within several processes, including cellular response to mechanical stimulus; regulation of ossification; and response to lipopolysaccharide. Predicted to be located in neuron projection terminus; neuronal cell body; and nuclear membrane. Predicted to be active in plasma membrane. Is expressed in central nervous system; early conceptus; heart valve; retina; and secondary oocyte. Used to study dilated cardiomyopathy. Human ortholog(s) of this gene implicated in ankylosing spondylitis; arteriosclerosis; and ulcerative colitis. Orthologous to human PTGER4 (prostaglandin E receptor 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in small intestine adult (RPKM 27.1), colon adult (RPKM 22.4) and 14 other tissues See more
Orthologs
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Genomic context

See Ptger4 in Genome Data Viewer
Location:
15 A1; 15 1.99 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (5262880..5273668, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (5233399..5244187, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene protein kinase, AMP-activated, alpha 1 catalytic subunit Neighboring gene predicted gene 15938 Neighboring gene tetratricopeptide repeat domain 33 Neighboring gene heat shock protein 90, alpha (cytosolic), class A member 1 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E2436 Neighboring gene STARR-seq mESC enhancer starr_37846 Neighboring gene predicted gene, 41257 Neighboring gene ribosomal protein L22 like 1 pseudogene Neighboring gene beta galactoside alpha 2,6 sialyltransferase 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (7)  1 citation
  • Endonuclease-mediated (6) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables prostaglandin E receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables prostaglandin E receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables prostaglandin E receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables prostaglandin receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in JNK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in T-helper cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in bone development ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to prostaglandin E stimulus IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in chemokinesis ISO
Inferred from Sequence Orthology
more info
 
involved_in ductus arteriosus closure ISO
Inferred from Sequence Orthology
more info
 
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within interleukin-33 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of ductus arteriosus closure ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of endothelin production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of eosinophil extravasation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of hydrogen peroxide metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within negative regulation of inflammatory response IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of integrin activation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of interleukin-1 alpha production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of nitric-oxide synthase biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of peptide secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of small intestine smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of antral ovarian follicle growth ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of bone resorption ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cAMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of calcitonin secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of chemokinesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of circadian sleep/wake cycle, non-REM sleep ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytokine production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of hyaluronan biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of interleukin-10 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of matrix metallopeptidase secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mucus secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neutrophil extravasation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ossification ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ovarian follicle development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of substance P secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of substance P secretion, neurotransmission ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of tyrosine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of urine volume ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of wound healing ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of circadian sleep/wake cycle, wakefulness ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of ossification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of stress fiber assembly IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to nematode IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuron projection terminus ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
prostaglandin E2 receptor EP4 subtype
Names
PGE2 receptor EP4 subtype
prostanoid EP4 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136079.2NP_001129551.1  prostaglandin E2 receptor EP4 subtype isoform 1

    See identical proteins and their annotated locations for NP_001129551.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 2. The encoded isoform (1) has a shorter N-terminus, compared to isoform 2.
    Source sequence(s)
    AC135079
    Consensus CDS
    CCDS49575.1
    UniProtKB/TrEMBL
    Q3UM94, Q91VE4
    Related
    ENSMUSP00000112858.2, ENSMUST00000120563.2
    Conserved Domains (2) summary
    pfam00001
    Location:34332
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:29229
    7tm_4; Olfactory receptor
  2. NM_008965.2NP_032991.1  prostaglandin E2 receptor EP4 subtype isoform 2

    See identical proteins and their annotated locations for NP_032991.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) encodes the longer isoform (2).
    Source sequence(s)
    AC135079
    Consensus CDS
    CCDS27365.1
    UniProtKB/Swiss-Prot
    P32240
    UniProtKB/TrEMBL
    Q3UM94
    Related
    ENSMUSP00000048736.9, ENSMUST00000047379.15
    Conserved Domains (2) summary
    pfam00001
    Location:59357
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:54254
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    5262880..5273668 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)