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MAN1C1 mannosidase alpha class 1C member 1 [ Homo sapiens (human) ]

Gene ID: 57134, updated on 11-Jun-2021

Summary

Official Symbol
MAN1C1provided by HGNC
Official Full Name
mannosidase alpha class 1C member 1provided by HGNC
Primary source
HGNC:HGNC:19080
See related
Ensembl:ENSG00000117643 MIM:616772
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HMIC; MAN1C; MAN1A3; pp6318
Expression
Ubiquitous expression in kidney (RPKM 10.6), thyroid (RPKM 9.8) and 23 other tissues See more
Orthologs
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Genomic context

See MAN1C1 in Genome Data Viewer
Location:
1p36.11
Exon count:
14
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (25616791..25786207)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (25943282..26110941)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene macoilin 1 Neighboring gene low density lipoprotein receptor adaptor protein 1 Neighboring gene selenoprotein N Neighboring gene uncharacterized LOC646471 Neighboring gene mitochondrial fission regulator 1 like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Specific alterations of the N-linked carbohydrates on HIV-1 gp120 and gp41 by glucosidases and mannosidase inhibitors can enhance mannose-binding lectin (MBL)-mediated neutralization of virus by strengthening the interaction of HIV-1 with MBL PubMed
env HIV-1 gp120 N-linked oligosaccharides are processed by manosidase I and II in the Golgi complex PubMed
Envelope surface glycoprotein gp160, precursor env Oligosaccharide side-chains of HIV-1 gp160 are processed by glycosidase I and II, mannosidase I and II, acetylglucosaminyl transferase I and II, and fucosyl, galactosyl and sialyl transferases in both the endoplasmic reticulum and golgi apparatus PubMed
Envelope transmembrane glycoprotein gp41 env Mannose-containing, N-linked oligosaccharide side-chains of HIV-1 gp41 are involved in the initial stage of infection by HIV-1; glycosylation inhibitors block virus-cell and cell-cell fusion and release of the virions PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding TAS
Traceable Author Statement
more info
PubMed 
enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in Golgi apparatus mannose trimming TAS
Traceable Author Statement
more info
 
involved_in N-glycan processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in protein N-linked glycosylation TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in Golgi membrane TAS
Traceable Author Statement
more info
 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular exosome HDA PubMed 
located_in integral component of Golgi membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
mannosyl-oligosaccharide 1,2-alpha-mannosidase IC
Names
1,2-alpha-mannosidase IC
processing alpha-1,2-mannosidase IC
NP_001275939.1
NP_001372111.1
NP_001372112.1
NP_001372113.1
NP_001372114.1
NP_065112.1
XP_016857349.1
XP_016857350.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289010.2NP_001275939.1  mannosyl-oligosaccharide 1,2-alpha-mannosidase IC isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL020996, AL031280
    UniProtKB/Swiss-Prot
    Q9NR34
    UniProtKB/TrEMBL
    Q59G34
    Conserved Domains (1) summary
    pfam01532
    Location:181589
    Glyco_hydro_47; Glycosyl hydrolase family 47
  2. NM_001385182.1NP_001372111.1  mannosyl-oligosaccharide 1,2-alpha-mannosidase IC isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL020996, AL031280
    Conserved Domains (1) summary
    pfam01532
    Location:181651
    Glyco_hydro_47; Glycosyl hydrolase family 47
  3. NM_001385183.1NP_001372112.1  mannosyl-oligosaccharide 1,2-alpha-mannosidase IC isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL020996, AL031280
    Conserved Domains (1) summary
    pfam01532
    Location:181641
    Glyco_hydro_47; Glycosyl hydrolase family 47
  4. NM_001385184.1NP_001372113.1  mannosyl-oligosaccharide 1,2-alpha-mannosidase IC isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL020996, AL031280
    Conserved Domains (1) summary
    pfam01532
    Location:214449
    Glyco_hydro_47; Glycosyl hydrolase family 47
  5. NM_001385185.1NP_001372114.1  mannosyl-oligosaccharide 1,2-alpha-mannosidase IC isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL020996, AL031280
    Related
    ENSP00000363449.1, ENST00000374329.1
    Conserved Domains (1) summary
    pfam01532
    Location:1388
    Glyco_hydro_47; Glycosyl hydrolase family 47
  6. NM_020379.4NP_065112.1  mannosyl-oligosaccharide 1,2-alpha-mannosidase IC isoform 1

    See identical proteins and their annotated locations for NP_065112.1

    Status: VALIDATED

    Source sequence(s)
    AL020996, AL031280
    Consensus CDS
    CCDS265.1
    UniProtKB/Swiss-Prot
    Q9NR34
    UniProtKB/TrEMBL
    Q59G34
    Related
    ENSP00000363452.4, ENST00000374332.9
    Conserved Domains (1) summary
    pfam01532
    Location:181617
    Glyco_hydro_47; Glycosyl hydrolase family 47

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    25616791..25786207
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017001861.1XP_016857350.1  mannosyl-oligosaccharide 1,2-alpha-mannosidase IC isoform X2

  2. XM_017001860.1XP_016857349.1  mannosyl-oligosaccharide 1,2-alpha-mannosidase IC isoform X1

    Conserved Domains (1) summary
    pfam01532
    Location:8374
    Glyco_hydro_47; Glycosyl hydrolase family 47

RNA

  1. XR_001737334.1 RNA Sequence

  2. XR_001737333.1 RNA Sequence

    Related
    ENST00000611903.4
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